Foreword: “Current trends in cancer and signalling”
Publication date: Available online 11 April 2018 Source:Advances in Biological Regulation Author(s): Pann-Ghill Suh (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - April 11, 2018 Category: Biology Source Type: research
Dual inhibition of PI3K/mTOR signaling in chemoresistant AML primary cells
Publication date: Available online 19 March 2018 Source:Advances in Biological Regulation Author(s): Jessika Bertacchini, Chiara Frasson, Francesca Chiarini, Daniele D'Avella, Benedetta Accordi, Laura Anselmi, Patrizia Barozzi, Fabio Foghieri, Mario Luppi, Alberto M. Martelli, Giuseppe Basso, Saki Najmaldin, Abbas Khosravi, Fakher Rahim, Sandra Marmiroli A main cause of treatment failure for AML patients is resistance to chemotherapy. Survival of AML cells may depend on mechanisms that elude conventional drugs action and/or on the presence of leukemia initiating cells at diagnosis, and their persistence af...
Source: Advances in Biological Regulation - March 20, 2018 Category: Biology Source Type: research
Phosphoinositide 3-kinase pathways and autophagy require phosphatidylinositol phosphate kinases
Publication date: Available online 8 February 2018 Source:Advances in Biological Regulation Author(s): Suyong Choi, Xander Houdek, Richard A. Anderson Phosphatidylinositol phosphate kinases (PIPKs) generate a lipid messenger phosphatidylinositol 4,5-bisphosphate (PI4,5P2) that controls essentially all aspects of cellular functions. PI4,5P2 rapidly diffuses in the membrane of the lipid bilayer and does not greatly change in membrane or cellular content, and thus PI4,5P2 generation by PIPKs is tightly linked to its usage in subcellular compartments. Based on this verity, recent study of PI4,5P2 signal transduction has b...
Source: Advances in Biological Regulation - February 20, 2018 Category: Biology Source Type: research
Application of HTLV-1 tax transgenic mice for therapeutic intervention
Publication date: Available online 13 February 2018 Source:Advances in Biological Regulation Author(s): Hideki Hasegawa, Kaori Sano, Akira Ainai, Tadaki Suzuki Adult T-cell leukemia-lymphoma (ATL) is a refractory T-cell malignancy caused by infection of human T-cell leukemia virus type I (HTLV-I). Although the pathogenesis of ATL remains unclear, HTLV-1 oncoprotein Tax plays an important role in pathogenesis (Matsuoka, 2003; Jeang et al., 2004). Chemotherapy resistance of ATL leads the poor prognosis of this disease. In order to understand the pathogenesis and establish an animal model useful for therapy attempts, we...
Source: Advances in Biological Regulation - February 14, 2018 Category: Biology Source Type: research
Metformin influences drug sensitivity in pancreatic cancer cells
Publication date: Available online 12 February 2018 Source:Advances in Biological Regulation Author(s): Saverio Candido, Stephen L. Abrams, Linda Steelman, Kvin Lertpiriyapong, Alberto M. Martelli, Lucio Cocco, Stefano Ratti, Matilde Y. Follo, Ramiro M. Murata, Pedro L. Rosalen, Paolo Lombardi, Giuseppe Montalto, Melchiorre Cervello, Agnieszka Gizak, Dariusz Rakus, Pann-Gill Suh, Massimo Libra, James A. McCubrey Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, highly metastatic malignancy and accounts for 85% of pancreatic cancers. PDAC patients have poor prognosis with a five-year survival of ...
Source: Advances in Biological Regulation - February 12, 2018 Category: Biology Source Type: research
E.Dennis, Special lecturer photo
Publication date: January 2018 Source:Advances in Biological Regulation, Volume 67 (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - February 9, 2018 Category: Biology Source Type: research
Flimsy overlay to Group photo
Publication date: January 2018 Source:Advances in Biological Regulation, Volume 67 (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - February 9, 2018 Category: Biology Source Type: research
Key to Group photo
Publication date: January 2018 Source:Advances in Biological Regulation, Volume 67 (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - February 9, 2018 Category: Biology Source Type: research
The inflammatory microenvironment that promotes gastrointestinal cancer development and invasion
Publication date: Available online 5 February 2018 Source:Advances in Biological Regulation Author(s): Kanae Echizen, Hiroko Oshima, Mizuho Nakayama, Masanobu Oshima Accumulating evidence has indicated that the inflammatory response is important for tumor promotion. However, the mechanisms underlying the induction of the inflammatory response in cancer tissues and how it promotes tumorigenesis remain poorly understood. We constructed several mouse models that develop inflammation-associated gastric and intestinal tumors and examined the in vivo mechanisms of tumorigenesis. Of note, the activation of cyclooxygenase-2 ...
Source: Advances in Biological Regulation - February 5, 2018 Category: Biology Source Type: research
Advances in Biological Regulation
Publication date: January 2018 Source:Advances in Biological Regulation, Volume 67 (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - February 3, 2018 Category: Biology Source Type: research
Interaction of the Wnt/ β-catenin and RAS-ERK pathways involving co-stabilization of both β-catenin and RAS plays important roles in the colorectal tumorigenesis
Publication date: Available online 10 January 2018 Source:Advances in Biological Regulation Author(s): Sang-Kyu Lee, Jeong-Ha Hwang, Kang-Yell Choi Cancer development is usually driven by multiple genetic and molecular alterations rather than by a single defect. In the human colorectal cancer (CRC), series of mutations of genes are involved in the different stages of tumorigenesis. For example, the adenomatous polyposis coli (APC) and KRAS mutations have been known to play roles in the initiation and progression of the tumorigenesis, respectively. However, many studies indicate that mutations of these two genes, which...
Source: Advances in Biological Regulation - February 2, 2018 Category: Biology Source Type: research
Disrupting the ‘Warburg effect’ re-routes cancer cells to OXPHOS offering a vulnerability point via ‘ferroptosis’-induced cell death
Publication date: Available online 28 December 2017 Source:Advances in Biological Regulation Author(s): Maša Ždralević, Milica Vučetić, Boutaina Daher, Ibtissam Marchiq, Scott K. Parks, Jacques Pouysségur The evolution of life from extreme hypoxic environments to an oxygen-rich atmosphere has progressively selected for successful metabolic, enzymatic and bioenergetic networks through which a myriad of organisms survive the most extreme environmental conditions. From the two lethal environments anoxia/high O2, cells have developed survival strategies through expression of the transcriptional factors ATF4, HIF1...
Source: Advances in Biological Regulation - December 29, 2017 Category: Biology Source Type: research
Remodeling of Ca2+ signaling in cancer: Regulation of inositol 1,4,5-trisphosphate receptors through oncogenes and tumor suppressors
Publication date: Available online 20 December 2017 Source:Advances in Biological Regulation Author(s): Hideaki Ando, Katsuhiro Kawaai, Benjamin Bonneau, Katsuhiko Mikoshiba The calcium ion (Ca2+) is a ubiquitous intracellular signaling molecule that regulates diverse physiological and pathological processes, including cancer. Increasing evidence indicates that oncogenes and tumor suppressors regulate the Ca2+ transport systems. Inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs) are IP3-activated Ca2+ release channels located on the endoplasmic reticulum (ER). They play pivotal roles in the regulation of cell death...
Source: Advances in Biological Regulation - December 21, 2017 Category: Biology Source Type: research
Sphingosine kinase 1 in breast cancer
Publication date: Available online 16 October 2017 Source:Advances in Biological Regulation Author(s): Kurt Geffken, Sarah Spiegel Breast cancer affects 1 out of 8 women in the US and is the second highest cause of death from cancer for women, leading to considerable research examining the causes, progression, and treatment of breast cancer. Over the last two decades, sphingosine-1-phosphate (S1P), a potent sphingolipid metabolite, has been implicated in many processes important for breast cancer including growth, progression, transformation and metastasis, and is the focus of this review. In particular, one of the kin...
Source: Advances in Biological Regulation - December 16, 2017 Category: Biology Source Type: research
Signaling by cell surface death receptors: Alterations in head and neck cancer
Publication date: Available online 18 October 2017 Source:Advances in Biological Regulation Author(s): Brandon C. Leonard, Daniel E. Johnson Cell surface death receptors are members of the tumor necrosis factor receptor (TNFR) superfamily and mediate signals leading to the induction of apoptosis or necroptosis, as well as NF-κB-mediated cell survival. These biochemical processes play key roles in cell growth, development, tissue homeostasis, and immune responses. The downstream signaling complexes activated by different death receptors can differ significantly and are subject to multiple, distinct regulatory mechanism...
Source: Advances in Biological Regulation - December 16, 2017 Category: Biology Source Type: research
