Role of the malonyl-CoA synthetase ACSF3 in mitochondrial metabolism
Publication date: Available online 5 September 2018Source: Advances in Biological RegulationAuthor(s): Caitlyn E. Bowman, Michael J. WolfgangAbstractMalonyl-CoA is a central metabolite in fatty acid biochemistry. It is the rate-determining intermediate in fatty acid synthesis but is also an allosteric inhibitor of the rate-setting step in mitochondrial long-chain fatty acid oxidation. While these canonical cytoplasmic roles of malonyl-CoA have been well described, malonyl-CoA can also be generated within the mitochondrial matrix by an alternative pathway: the ATP-dependent ligation of malonate to Coenzyme A by the malonyl-...
Source: Advances in Biological Regulation - September 6, 2018 Category: Biology Source Type: research
Orm/ORMDL proteins: Gate guardians and master regulators
Publication date: Available online 31 August 2018Source: Advances in Biological RegulationAuthor(s): Deanna Davis, Muthukumar Kannan, Binks WattenbergAbstractSphingolipids comprise a diverse family of lipids that perform multiple functions in both structure of cellular membranes and intra- and inter-cellular signaling. The diversity of this family is generated by an array of enzymes that produce individual classes and molecular species of family members and enzymes which catabolize those lipids for recycling pathways. However, all of these lipids begin their lives with a single step, the condensation of an amino acid, almo...
Source: Advances in Biological Regulation - September 1, 2018 Category: Biology Source Type: research
Niemann-Pick type C disease: The atypical sphingolipidosis
Publication date: Available online 28 August 2018Source: Advances in Biological RegulationAuthor(s): Jason Newton, Sheldon Milstien, Sarah SpiegelAbstractNiemann-Pick type C (NPC) disease is a lysosomal storage disorder resulting from mutations in either the NPC1 (95%) or NPC2 (5%) genes. NPC typically presents in childhood with visceral lipid accumulation and complex progressive neurodegeneration characterized by cerebellar ataxia, dysphagia, and dementia, resulting in a shortened lifespan. While cholesterol is widely acknowledged as the principal storage lipid in NPC, multiple species of sphingolipids accumulate as well....
Source: Advances in Biological Regulation - August 29, 2018 Category: Biology Source Type: research
Editorial Board
Publication date: August 2018Source: Advances in Biological Regulation, Volume 69Author(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - August 18, 2018 Category: Biology Source Type: research
Where do substrates of diacylglycerol kinases come from? Diacylglycerol kinases utilize diacylglycerol species supplied from phosphatidylinositol turnover-independent pathways
Publication date: January 2018Source: Advances in Biological Regulation, Volume 67Author(s): Fumio Sakane, Satoru Mizuno, Daisuke Takahashi, Hiromichi SakaiAbstractDiacylglycerol kinase (DGK) phosphorylates diacylglycerol (DG) to produce phosphatidic acid (PA). Mammalian DGK comprises ten isozymes (α–κ) and regulates a wide variety of physiological and pathological events, such as cancer, type II diabetes, neuronal disorders and immune responses. DG and PA consist of various molecular species that have different acyl chains at the sn-1 and sn-2 positions, and consequently, mammalian cells contain at least 50 structural...
Source: Advances in Biological Regulation - July 11, 2018 Category: Biology Source Type: research
Review of four major distinct types of human phospholipase A2
Publication date: January 2018Source: Advances in Biological Regulation, Volume 67Author(s): Alexis M. Vasquez, Varnavas D. Mouchlis, Edward A. DennisAbstractThe phospholipase A2 superfamily of enzymes plays a significant role in the development and progression of numerous inflammatory diseases. Through their catalytic action on membrane phospholipids, phospholipases are the upstream regulators of the eicosanoid pathway releasing free fatty acids for cyclooxygenases, lipoxygenases, and cytochrome P450 enzymes which produce various well-known inflammatory mediators including leukotrienes, thromboxanes and prostaglandins. El...
Source: Advances in Biological Regulation - July 11, 2018 Category: Biology Source Type: research
Effects of berberine, curcumin, resveratrol alone and in combination with chemotherapeutic drugs and signal transduction inhibitors on cancer cells—Power of nutraceuticals
Publication date: January 2018Source: Advances in Biological Regulation, Volume 67Author(s): James A. McCubrey, Stephen L. Abrams, Kvin Lertpiriyapong, Lucio Cocco, Stefano Ratti, Alberto M. Martelli, Saverio Candido, Massimo Libra, Ramiro M. Murata, Pedro L. Rosalen, Paolo Lombardi, Giuseppe Montalto, Melchiorre Cervello, Agnieszka Gizak, Dariusz Rakus, Linda S. SteelmanAbstractOver the past fifty years, society has become aware of the importance of a healthy diet in terms of human fitness and longevity. More recently, the concept of the beneficial effects of certain components of our diet and other compounds, that are co...
Source: Advances in Biological Regulation - July 11, 2018 Category: Biology Source Type: research
PLCγ1: Potential arbitrator of cancer progression
Publication date: January 2018Source: Advances in Biological Regulation, Volume 67Author(s): Hyun-Jun Jang, Pann-Ghill Suh, Yu Jin Lee, Kyeong Jin Shin, Lucio Cocco, Young Chan ChaeAbstractPhospholipase C (PLC) is an essential mediator of cellular signaling. PLC regulates multiple cellular processes by generating bioactive molecules such as inositol-1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These products propagate and regulate cellular signaling via calcium (Ca2+) mobilization and activation of protein kinase C (PKC), other kinases, and ion channels. PLCγ1, one of the primary subtypes of PLC, is directly activat...
Source: Advances in Biological Regulation - July 11, 2018 Category: Biology Source Type: research
Signaling by cell surface death receptors: Alterations in head and neck cancer
Publication date: January 2018Source: Advances in Biological Regulation, Volume 67Author(s): Brandon C. Leonard, Daniel E. JohnsonAbstractCell surface death receptors are members of the tumor necrosis factor receptor (TNFR) superfamily and mediate signals leading to the induction of apoptosis or necroptosis, as well as NF-κB-mediated cell survival. These biochemical processes play key roles in cell growth, development, tissue homeostasis, and immune responses. The downstream signaling complexes activated by different death receptors can differ significantly and are subject to multiple, distinct regulatory mechanisms. Dysr...
Source: Advances in Biological Regulation - July 11, 2018 Category: Biology Source Type: research
Advances in Biological Regulation
Publication date: January 2018Source: Advances in Biological Regulation, Volume 67Author(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - July 11, 2018 Category: Biology Source Type: research
Acknowledgements
Publication date: January 2018Source: Advances in Biological Regulation, Volume 67Author(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - July 11, 2018 Category: Biology Source Type: research
Foreword
Publication date: January 2018Source: Advances in Biological Regulation, Volume 67Author(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - July 11, 2018 Category: Biology Source Type: research
Group photo
Publication date: January 2018Source: Advances in Biological Regulation, Volume 67Author(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - July 11, 2018 Category: Biology Source Type: research
Key to Group photo
Publication date: January 2018Source: Advances in Biological Regulation, Volume 67Author(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - July 11, 2018 Category: Biology Source Type: research
Flimsy overlay to Group photo
Publication date: January 2018Source: Advances in Biological Regulation, Volume 67Author(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - July 11, 2018 Category: Biology Source Type: research
