Regulation of ASK1 signaling by scaffold and adaptor proteins
Publication date: December 2017 Source:Advances in Biological Regulation, Volume 66 Author(s): Lauren Rusnak, Haian Fu The mitogen-activated protein kinase (MAPK) signaling pathway is a three-tiered kinase cascade where mitogen-activated protein kinase kinase kinases (MAP3Ks) lead to the activation of mitogen-activated protein kinase kinases (MAP2K), and ultimately MAPK proteins. MAPK signaling can promote a diverse set of biological outcomes, ranging from cell death to proliferation. There are multiple mechanisms which govern MAPK output, such as the duration and strength of the signal, cellular localization to upstre...
Source: Advances in Biological Regulation - December 16, 2017 Category: Biology Source Type: research
Effects of berberine, curcumin, resveratrol alone and in combination with chemotherapeutic drugs and signal transduction inhibitors on cancer cells —Power of nutraceuticals
Publication date: Available online 3 October 2017 Source:Advances in Biological Regulation Author(s): James A. McCubrey, Steve L. Abrams, Kvin Lertpiriyapong, Lucio Cocco, Stefano Ratti, Alberto M. Martelli, Saverio Candido, Massimo Libra, Ramiro M. Murata, Pedro L. Rosalen, Paolo Lombardi, Giuseppe Montalto, Melchiorre Cervello, Agnieszka Gizak, Dariusz Rakus, Linda S. Steelman Over the past fifty years, society has become aware of the importance of a healthy diet in terms of human fitness and longevity. More recently, the concept of the beneficial effects of certain components of our diet and other comp...
Source: Advances in Biological Regulation - October 3, 2017 Category: Biology Source Type: research
The importance of blood platelet lipid signaling in thrombosis and in sepsis
Publication date: Available online 29 September 2017 Source:Advances in Biological Regulation Author(s): Fanny Vardon Bounes, Abdulrahman Mujalli, Claire Cenac, Sonia Severin, Pauline Lefaouder, Gaëtan Chicanne, Frédérique Gaits-Iacovoni, Vincent Minville, Marie-Pierre Gratacap, Bernard Payrastre Blood platelets are the first line of defense against hemorrhages and are also strongly involved in the processes of arterial thrombosis, a leading cause of death worldwide. Besides their well-established roles in hemostasis, vascular wall repair and thrombosis, platelets are now recognized as important players in o...
Source: Advances in Biological Regulation - September 29, 2017 Category: Biology Source Type: research
DGK ζ ablation engenders upregulation of p53 level in the spleen upon whole-body ionizing radiation
This study was conducted to elucidate this point using an experiment with DGKζ-KO mice under DNA damage induced by whole-body ionizing radiation. Our results reveal that p53 protein is induced robustly in the spleen of DGKζ-KO mice upon exposure to ionizing radiation, thereby promoting apoptosis in this organ. Taken together, the results demonstrate that DGKζ plays a sentinel role in p53 expression at the cellular and organismal levels after DNA damaging stress conditions. (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - September 28, 2017 Category: Biology Source Type: research
Phosphatidic acid-producing enzymes regulating the synaptic vesicle cycle: Role for PLD?
Publication date: Available online 28 September 2017 Source:Advances in Biological Regulation Author(s): Casey N. Barber, Richard L. Huganir, Daniel M. Raben In cortical and hippocampal neurons of the mammalian brain, the synaptic vesicle cycle is a series of steps that tightly regulate exo- and endocytosis of vesicles. Many proteins contribute to this regulation, but lipids have recently emerged as critical regulators as well. Of all the many lipid signaling molecules, phosphatidic acid is important to the physical processes of membrane fusion. Therefore, the lipid-metabolizing enzymes that produce phosphatidic acid ...
Source: Advances in Biological Regulation - September 28, 2017 Category: Biology Source Type: research
