New advances in targeting aberrant signaling pathways in T-cell Acute Lymphoblastic Leukemia
Publication date: Available online 5 September 2019Source: Advances in Biological RegulationAuthor(s): Francesca Paganelli, Annalisa Lonetti, Laura Anselmi, Alberto M. Martelli, Camilla Evangelisti, Francesca ChiariniAbstractT-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disorder characterized by malignant transformation of immature progenitors primed towards T-cell development.Over the past 15 years, advances in the molecular characterization of T-ALL have uncovered oncogenic key drivers and crucial signaling pathways of this disease, opening new chances for the development of novel therapeutic strategies. C...
Source: Advances in Biological Regulation - September 6, 2019 Category: Biology Source Type: research
MicroRNAs and their involvement in T-ALL: a brief overview
Publication date: Available online 5 September 2019Source: Advances in Biological RegulationAuthor(s): Nádia C. Correia, João T. BarataAbstractT-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy in which the transformed clone is arrested during T-cell development. Several genetic and epigenetic events have been implicated in this transformation. MicroRNAs (miRNAs) are small, non-coding RNAs that primarily function as endogenous translational repressors of protein-coding genes. The involvement of miRNAs in the regulation of cancer progression is well-established, namely by down-regulating the expressio...
Source: Advances in Biological Regulation - September 5, 2019 Category: Biology Source Type: research
Multi-omic approaches to improve outcome for T-cell acute lymphoblastic leukemia patients
Publication date: Available online 26 August 2019Source: Advances in Biological RegulationAuthor(s): Jordy C.G. van der Zwet, Valentina Cordo, Kirsten Canté-Barrett, Jules P.P. MeijerinkAbstractIn the last decade, tremendous progress in curative treatment has been made for T-ALL patients using high-intensive, risk-adapted multi-agent chemotherapy. Further treatment intensification to improve the cure rate is not feasible as it will increase the number of toxic deaths. Hence, about 20% of pediatric patients relapse and often die due to acquired therapy resistance. Personalized medicine is of utmost importance to further in...
Source: Advances in Biological Regulation - August 27, 2019 Category: Biology Source Type: research
Editorial Board
Publication date: August 2019Source: Advances in Biological Regulation, Volume 73Author(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - August 17, 2019 Category: Biology Source Type: research
The role of phospholipase Cβ on the plasma membrane and in the cytosol: How modular domains enable novel functions
Publication date: Available online 29 July 2019Source: Advances in Biological RegulationAuthor(s): Suzanne ScarlataAbstractPhospholipase Cβ (PLCβ) is a signaling enzyme activated by G proteins to generate calcium signals. The catalytic core of PLCβ is surrounded by modular domains that mediate the interaction of the enzyme with known protein partners on the plasma membrane. The C-terminal region PLCβ contains a novel coiled-coil domain that is required for Gαq binding and activation. Recent work has shown that this domain also binds a number of cytosolic proteins that regulate protein translation, and that these prote...
Source: Advances in Biological Regulation - August 11, 2019 Category: Biology Source Type: research
A synthetic biological approach to reconstitution of inositide signaling pathways in bacteria
We report a molecular genetic approach that reconstitutes eukaryotic inositide lipid and soluble pathways in a prokaryotic cell which inherently lack inositide kinases and phosphatases in their genome. By expressing synthetic cassettes of eukaryotic genes, we have reconstructed the heterologous formation of a range of inositide lipids, including PI(3)P, PI(4,5)P2 and PIP3. In addition, we report the reconstruction of lipid-dependent production of inositol hexakisphosphate (IP6). Our synthetic system is scalable, reduces confounding metabolic issues, for example it is devoid of inositide phosphatases and orthologous kinases...
Source: Advances in Biological Regulation - July 31, 2019 Category: Biology Source Type: research
The Role of Phospholipase Cβ on the Plasma Membrane and Cytosol: How Modular Domains Enable Novel Functions
Publication date: Available online 29 July 2019Source: Advances in Biological RegulationAuthor(s): Suzanne ScarlataAbstractPhospholipase Cβ (PLCβ) is a signaling enzyme activated by G proteins to generate calcium signals. The catalytic core of PLCβ is surrounded by modular domains that mediate the interaction of the enzyme with known protein partners on the plasma membrane. The C-terminal region PLCβ contains a novel coiled-coil domain that is required for Gαq binding and activation. Recent work has shown that this domain also binds a number of cytosolic proteins that regulate protein translation, and that these prote...
Source: Advances in Biological Regulation - July 30, 2019 Category: Biology Source Type: research
Protein-protein interaction analysis highlights the role of septins in membrane enclosed lumen and mRNA processing
Publication date: Available online 27 July 2019Source: Advances in Biological RegulationAuthor(s): Christophe Desterke, Ama Gassama-DiagneAbstractSeptins are a family of GTP-binding proteins that assemble into non-polar filaments which can be recruited to negatively charged membranes and serve as a scaffold to recruit cytosolic proteins and cytoskeletal elements such as microtubules and actin so that they can perform their important biological functions. Human septins consist of four groups, each with 13 members, and filaments formation usually involve members from each group in specific positions. However, little is known...
Source: Advances in Biological Regulation - July 28, 2019 Category: Biology Source Type: research
ZEB2 in T-cells and T-ALL
Publication date: Available online 27 July 2019Source: Advances in Biological RegulationAuthor(s): Stien De Coninck, Geert Berx, Tom Taghon, Pieter Van Vlierberghe, Steven GoossensAbstractThe identification of the rare but recurrent t(2;14)(q22;q32) translocation involving the ZEB2 locus in T-cell acute lymphoblastic leukemia, suggested that ZEB2 is an oncogenic driver of this high-risk subtype of leukemia. ZEB2, a zinc finger E-box homeobox binding transcription factor, is a master regulator of cellular plasticity and its expression is correlated with poor overall survival of cancer patients. Recent loss- and gain-of-func...
Source: Advances in Biological Regulation - July 27, 2019 Category: Biology Source Type: research
The TCR/CD3 complex in leukemogenesis and as a therapeutic target in T-cell acute lymphoblastic leukemia
Publication date: Available online 27 July 2019Source: Advances in Biological RegulationAuthor(s): Nuno R. dos Santos, Jacques Ghysdael, Christine Tran QuangAbstractT-cell acute lymphoblastic leukemia (T-ALL) arises from T cell precursors and is characterized by expression of many lineage-specific proteins. While T-cell antigen receptor (TCR) signaling and its strength are central for thymocyte development, mature T cell homeostasis and immune responses, their roles in T-ALL remain undetermined. Indeed, in contrast to mouse models, in which absence of TCR or major histocompatibility complex binding does not impact on leuke...
Source: Advances in Biological Regulation - July 27, 2019 Category: Biology Source Type: research
Desperately seeking a home marrow niche for T-cell acute lymphoblastic Leukaemia
Publication date: Available online 27 July 2019Source: Advances in Biological RegulationAuthor(s): Julien Calvo, Lucine Fahy, Benjamin Uzan, Françoise PflumioAbstractT-cell acute leukemia is a hematologic malignancy that results from the progressive acquisition of genomic abnormalities in T-cell progenitors/precursors. T-ALL is commonly thought to originate from the thymus albeit recent literature describes the possible acquisition of first oncogenic hits in hematopoietic progenitor cells of the bone marrow (BM). The journey of T-ALL from its arising to full blown expansion meets different microenvironments, including the...
Source: Advances in Biological Regulation - July 27, 2019 Category: Biology Source Type: research
Editorial Board
Publication date: May 2019Source: Advances in Biological Regulation, Volume 72Author(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - April 27, 2019 Category: Biology Source Type: research
ABCC3 is a novel target for the treatment of pancreatic cancer
Publication date: Available online 24 April 2019Source: Advances in Biological RegulationAuthor(s): Aleksandra Adamska, Riccardo Ferro, Rossano Lattanzio, Emily Capone, Alice Domenichini, Verena Damiani, Giovanna Chiorino, Begum Gokcen Akkaya, Kenneth J. Linton, Vincenzo De Laurenzi, Gianluca Sala, Marco FalascaAbstractPancreatic Ductal Adenocarcinoma (PDAC) is a very aggressive disease, lacking effective therapeutic approaches and leaving PDAC patients with a poor prognosis. The life expectancy of PDAC patients has not experienced a significant change in the last few decades with a five-year survival rate of only 8%. To a...
Source: Advances in Biological Regulation - April 25, 2019 Category: Biology Source Type: research
Abilities of berberine and chemically modified berberines to interact with metformin and inhibit proliferation of pancreatic cancer cells
Publication date: Available online 21 April 2019Source: Advances in Biological RegulationAuthor(s): Shaw M. Akula, Saverio Candido, Massimo Libra, Stephen L. Abrams, Linda S. Steelman, Kvin Lertpiriyapong, Giulia Ramazzotti, Stefano Ratti, Matilde Y. Follo, Alberto M. Martelli, Ramiro M. Murata, Pedro L. Rosalen, Bruno Bueno-Silva, Severino Matias de Alencar, Giuseppe Montalto, Melchiorre Cervello, Agnieszka Gizak, Dariusz Rakus, Weifeng Mao, Heng-Liang LinAbstractPancreatic cancer is devastating cancer worldwide with few if any truly effective therapies. Pancreatic cancer has an increasing incidence and may become the sec...
Source: Advances in Biological Regulation - April 22, 2019 Category: Biology Source Type: research
Phosphoinositide spatially free AKT/PKB activation to all membrane compartments
Publication date: Available online 11 April 2019Source: Advances in Biological RegulationAuthor(s): Narendra Thapa, Hudson Tyler Horn, Richard A. AndersonAbstractSer and Thr kinase AKT also known as protein kinase B (PKB) was discovered more than two and half decades ago and is one of the key downstream molecules in the phosphoinositide 3-kinase signaling pathways. The pleiotropic effects of this kinase have attracted intense interest and limelight in cancer biology, cancer therapy, diabetes, and cardiovascular diseases. Authors may refer to other more comprehensive and recent reviews on AKT/PKB (Manning and Cantley, 2007;...
Source: Advances in Biological Regulation - April 13, 2019 Category: Biology Source Type: research
