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Addiction Biology, Ahead of Print. (Source: Addiction Biology)
Source: Addiction Biology - November 27, 2017 Category: Addiction Source Type: research
Shared additive genetic variation for alcohol dependence among subjects of African and European ancestry
Abstract
Alcohol dependence (AD) affects individuals from all racial/ethnic groups, and previous research suggests that there is considerable variation in AD risk between and among various ancestrally defined groups in the United States. Although the reasons for these differences are likely due in part to contributions of complex sociocultural factors, limited research has attempted to examine whether similar genetic variation plays a role across ancestral groups. Using a pooled sample of individuals of African and European ancestry (AA/EA) obtained through data shared within the Database for Genotypes and Phenotypes, we e...
Source: Addiction Biology - November 27, 2017 Category: Addiction Authors: Leslie A. Brick, Matthew C. Keller, Valerie S. Knopik, John E. McGeary, Rohan H.C. Palmer Tags: Original Article Source Type: research
Environmental enrichment and drug value: a behavioral economic analysis in male rats
Abstract
Rats raised in an enriched condition (EC) show decreased stimulant self‐administration relative to rats reared in an isolated condition (IC). However, few studies have examined the behavioral mechanisms underlying this environment‐induced difference in self‐administration. Because economic demand for drugs of abuse predicts addiction‐like behavior in both humans and animals, we applied a behavioral economic analysis to cocaine self‐administration data in EC and IC rats. During cocaine self‐administration, the dose decreased across blocks of trials (0.75–0.003 mg/kg/inf), which allowed for a determin...
Source: Addiction Biology - November 27, 2017 Category: Addiction Authors: Justin R. Yates, Michael T. Bardo, Joshua S. Beckmann Tags: Original Article Source Type: research
N ‐Methyl‐d‐aspartate receptor co‐agonist availability affects behavioral and neurochemical responses to cocaine: insights into comorbid schizophrenia and substance abuse
Addiction Biology, EarlyView. (Source: Addiction Biology)
Source: Addiction Biology - November 23, 2017 Category: Addiction Source Type: research
Adolescent ethanol intake alters cannabinoid type ‐1 receptor localization in astrocytes of the adult mouse hippocampus
Addiction Biology, EarlyView. (Source: Addiction Biology)
Source: Addiction Biology - November 23, 2017 Category: Addiction Source Type: research
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Addiction Biology, Ahead of Print. (Source: Addiction Biology)
Source: Addiction Biology - November 23, 2017 Category: Addiction Source Type: research
Adolescent ethanol intake alters cannabinoid type ‐1 receptor localization in astrocytes of the adult mouse hippocampus
Abstract
Cannabinoid type‐1 (CB1) receptors are widely distributed in the brain and play important roles in astrocyte function and the modulation of neuronal synaptic transmission and plasticity. However, it is currently unknown how CB1 receptor expression in astrocytes is affected by long‐term exposure to stressors. Here we examined CB1 receptors in astrocytes of ethanol (EtOH)‐exposed adolescent mice to determine its effect on CB1 receptor localization and density in adult brain. 4–8‐week‐old male mice were exposed to 20 percent EtOH over a period of 4 weeks, and receptor localization was examined after 4 w...
Source: Addiction Biology - November 23, 2017 Category: Addiction Authors: Itziar Bonilla ‐Del Rίo, Nagore Puente, Sara Peñasco, Irantzu Rico, Ana Gutiérrez‐Rodrίguez, Izaskun Elezgarai, Almudena Ramos, Leire Reguero, Inmaculada Gerrikagoitia, Brian R. Christie, Patrick Nahirney, Pedro Grandes Tags: Original Article Source Type: research
Working memory predicts methamphetamine hair concentration over the course of treatment: moderating effect of impulsivity and implications for dual ‐systems model
Addiction Biology, EarlyView. (Source: Addiction Biology)
Source: Addiction Biology - November 8, 2017 Category: Addiction Source Type: research
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Addiction Biology, Ahead of Print. (Source: Addiction Biology)
Source: Addiction Biology - November 8, 2017 Category: Addiction Source Type: research
Mu opioid receptors in GABAergic neurons of the forebrain promote alcohol reward and drinking
Addiction Biology, EarlyView. (Source: Addiction Biology)
Source: Addiction Biology - November 2, 2017 Category: Addiction Source Type: research
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Addiction Biology, Ahead of Print. (Source: Addiction Biology)
Source: Addiction Biology - November 2, 2017 Category: Addiction Source Type: research
Cocaine conditioned place preference: unexpected suppression of preference due to testing combined with strong conditioning
This study emphasizes the complex nature of CPP memory and the importance of multiple parameters that must be taken into consideration when investigating reconsolidation.
Blockade of D1 receptors during reconditioning prevented extracellular signal‐regulated kinase activation and induced a loss of conditioned place preference (CPP). We also unexpectedly observed a CPP disappearance in mice that underwent testing and reconditioning with cocaine alone, specifically in strong conditioning conditions. Our data emphasize the complex nature of CPP memory and the importance of multiple parameters that must be taken into consid...
Source: Addiction Biology - November 1, 2017 Category: Addiction Authors: Lucile Marion ‐Poll, Antoine Besnard, Sophie Longueville, Emmanuel Valjent, Olivia Engmann, Jocelyne Caboche, Denis Hervé, Jean‐Antoine Girault Tags: Original Article Source Type: research
