Lysophosphatidic acid ‐induced increase in adult hippocampal neurogenesis facilitates the forgetting of cocaine‐contextual memory
Abstract
Erasing memories of cocaine–stimuli associations might have important clinical implications for addiction therapy. Stimulating hippocampal plasticity by enhancing adult hippocampal neurogenesis (AHN) is a promising strategy because the addition of new neurons may not only facilitate new learning but also modify previous connections and weaken retrograde memories. To investigate whether increasing AHN prompted the forgetting of previous contextual cocaine associations, mice trained in a cocaine‐induced conditioned place preference (CPP) paradigm were administered chronic intracerebroventricular infusions of lys...
Source: Addiction Biology - February 26, 2018 Category: Addiction Authors: David Ladr ón de Guevara‐Miranda, Román Darío Moreno‐Fernández, Sara Gil‐Rodríguez, Cristina Rosell‐Valle, Guillermo Estivill‐Torrús, Antonia Serrano, Francisco J. Pavón, Fernando Rodríguez de Fonseca, Luis J. Santín, Estela Castilla‐ Tags: Original Article Source Type: research
Not all smokers appear to seek nicotine for the same reasons: implications for preclinical research in nicotine dependence
Abstract
Tobacco use leads to 6 million deaths every year due to severe long‐lasting diseases. The main component of tobacco, nicotine, is recognized as one of the most addictive drugs, making smoking cessation difficult, even when 70 percent of smokers wish to do so. Clinical and preclinical studies have demonstrated consistently that nicotine seeking is a complex behavior involving various psychopharmacological mechanisms. Evidence supports that the population of smokers is heterogeneous, particularly as regards the breadth of motives that determine the urge to smoke. Here, we review converging psychological, genetic a...
Source: Addiction Biology - February 26, 2018 Category: Addiction Authors: Vernon Garcia ‐Rivas, Véronique Deroche‐Gamonet Tags: Invited Review Source Type: research
DRD2 promoter methylation and measures of alcohol reward: functional activation of reward circuits and clinical severity
Abstract
Studies have identified strong associations between D2 receptor binding potential and neural responses to rewarding stimuli and substance use. Thus, D2 receptor perturbations are central to theoretical models of the pathophysiology of substance dependence, and epigenetic changes may represent one of the fundamental molecular mechanisms impacting the effects of alcohol exposure on the brain. We hypothesized that epigenetic alterations in the promoter region of the dopamine D2 receptor (DRD2) gene would be associated with cue‐elicited activation of neural reward regions, as well as severity of alcohol use behavior...
Source: Addiction Biology - February 21, 2018 Category: Addiction Authors: L. Cinnamon Bidwell, Hollis C. Karoly, Rachel E. Thayer, Eric D. Claus, Angela D. Bryan, Barbara J. Weiland, Sophie YorkWilliams, Kent E. Hutchison Tags: Original Article Source Type: research
DRD2 promoter methylation and measures of alcohol reward: functional activation of reward circuits and clinical severity
Addiction Biology, EarlyView. (Source: Addiction Biology)
Source: Addiction Biology - February 21, 2018 Category: Addiction Source Type: research
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Addiction Biology, Ahead of Print. (Source: Addiction Biology)
Source: Addiction Biology - February 21, 2018 Category: Addiction Source Type: research
Effects of alcohol intoxication on self ‐reported drinking patterns, expectancies, motives and personality: a randomized controlled experimental study
Abstract
Alcohol intoxication may affect self‐reports of alcohol use and related constructs, such as impulsivity and dependence symptoms. Improved knowledge about potential systematic reporting biases induced by alcohol, e.g. through disinhibition, may be relevant for the assessment of intoxicated individuals both in clinical routine and research. We therefore randomly assigned 54 socially drinking males aged 18 to 19 without lifetime diagnosis of DSM‐IV alcohol dependence to one of two experimental arms: either placebo infusion at day 1 and alcohol infusion at day 2, or vice versa. The lab‐based intravenous alcohol ...
Source: Addiction Biology - February 19, 2018 Category: Addiction Authors: S ören Kuitunen‐Paul, Elisabeth Obst, Ruth Schmidt, Christian Sommer, Paula T. Kuitunen, Hans‐Ulrich Wittchen, Ulrich S. Zimmermann Tags: Original Article Source Type: research
Effects of alcohol intoxication on self ‐reported drinking patterns, expectancies, motives and personality: a randomized controlled experimental study
Addiction Biology, EarlyView. (Source: Addiction Biology)
Source: Addiction Biology - February 19, 2018 Category: Addiction Source Type: research
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Addiction Biology, Ahead of Print. (Source: Addiction Biology)
Source: Addiction Biology - February 19, 2018 Category: Addiction Source Type: research
Time ‐dependent regional brain distribution of methadone and naltrexone in the treatment of opioid addiction
Abstract
Opioid addiction is a serious public health concern with severe health and social implications; therefore, extensive therapeutic efforts are required to keep users drug free. The two main pharmacological interventions, in the treatment of addiction, involve management with methadone an mu (μ)‐opioid agonist and treatment with naltrexone, μ‐opioid, kappa (κ)‐opioid and delta (δ)‐opioid antagonist. MET and NAL are believed to help individuals to derive maximum benefit from treatment and undergo a full recovery. The aim of this study was to determine the localization and distribution of MET and NAL, over ...
Source: Addiction Biology - February 14, 2018 Category: Addiction Authors: Belin G. Teklezgi, Annapurna Pamreddy, Sooraj Baijnath, Hendrik G. Kruger, Tricia Naicker, Nirmala D. Gopal, Thavendran Govender Tags: Original Article Source Type: research
Time ‐dependent regional brain distribution of methadone and naltrexone in the treatment of opioid addiction
Addiction Biology, EarlyView. (Source: Addiction Biology)
Source: Addiction Biology - February 14, 2018 Category: Addiction Source Type: research
Issue Information
Addiction Biology,Volume 23, Issue 2, Page 529-530, March 2018. (Source: Addiction Biology)
Source: Addiction Biology - February 14, 2018 Category: Addiction Source Type: research
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Addiction Biology, Ahead of Print. (Source: Addiction Biology)
Source: Addiction Biology - February 14, 2018 Category: Addiction Source Type: research
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Addiction Biology,Volume 23, Issue 2, Page 529-530, March 2018. (Source: Addiction Biology)
Source: Addiction Biology - February 14, 2018 Category: Addiction Source Type: research
Issue Information
No abstract is available for this article. (Source: Addiction Biology)
Source: Addiction Biology - February 14, 2018 Category: Addiction Tags: Issue Information Source Type: research
Medial habenula cholinergic signaling regulates cocaine ‐associated relapse‐like behavior
Addiction Biology, EarlyView. (Source: Addiction Biology)
Source: Addiction Biology - February 12, 2018 Category: Addiction Source Type: research
