Selective inhibition of M5 muscarinic acetylcholine receptors attenuates cocaine self ‐administration in rats
Addiction Biology, EarlyView. (Source: Addiction Biology)
Source: Addiction Biology - October 18, 2017 Category: Addiction Source Type: research
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Addiction Biology, Ahead of Print. (Source: Addiction Biology)
Source: Addiction Biology - October 18, 2017 Category: Addiction Source Type: research
Activated mesenchymal stem cell administration inhibits chronic alcohol drinking and suppresses relapse ‐like drinking in high‐alcohol drinker rats
This study supports the neuroinflammation‐chronic ethanol intake hypothesis and suggest that mesenchymal stem cell administration may be considered in the treatment of alcohol use disorders.
Neuroinflammation induced by ethanol has been proposed to perpetuate alcohol consumption. Present study shows that the administration of anti‐inflammatory human mesenchymal cells (hMSC) into the cerebrospinal fluid of rats that had consumed ethanol chronically inhibited their alcohol intake by 70% and reduced relapse binge‐like drinking by 80%. Astrocyte neuroinflammation induced in hippocampus by chronic ethanol consumption was...
Source: Addiction Biology - October 18, 2017 Category: Addiction Authors: Fernando Ezquer, Mar ía Elena Quintanilla, Paola Morales, Marcelo Ezquer, Carolyne Lespay‐Rebolledo, Mario Herrera‐Marschitz, Yedy Israel Tags: Original Article Source Type: research
Hypocretin receptor 1 knockdown in the ventral tegmental area attenuates mesolimbic dopamine signaling and reduces motivation for cocaine
Addiction Biology, EarlyView. (Source: Addiction Biology)
Source: Addiction Biology - October 2, 2017 Category: Addiction Source Type: research
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Addiction Biology, Ahead of Print. (Source: Addiction Biology)
Source: Addiction Biology - October 2, 2017 Category: Addiction Source Type: research
Minocycline increases firing rates of accumbal neurons and modifies the effects of morphine on neuronal activity
Addiction Biology, EarlyView. (Source: Addiction Biology)
Source: Addiction Biology - September 29, 2017 Category: Addiction Source Type: research
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Addiction Biology, Ahead of Print. (Source: Addiction Biology)
Source: Addiction Biology - September 29, 2017 Category: Addiction Source Type: research
Functional role for suppression of the insular –striatal circuit in modulating interoceptive effects of alcohol
Addiction Biology, EarlyView. (Source: Addiction Biology)
Source: Addiction Biology - September 27, 2017 Category: Addiction Source Type: research
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Addiction Biology, Ahead of Print. (Source: Addiction Biology)
Source: Addiction Biology - September 27, 2017 Category: Addiction Source Type: research
Limited potential of cebranopadol to produce opioid ‐type physical dependence in rodents
Addiction Biology, EarlyView. (Source: Addiction Biology)
Source: Addiction Biology - September 25, 2017 Category: Addiction Source Type: research
Imaging the neuroimmune response to alcohol exposure in adolescent baboons: a TSPO PET study using 18F ‐DPA‐714
Addiction Biology, EarlyView. (Source: Addiction Biology)
Source: Addiction Biology - September 25, 2017 Category: Addiction Source Type: research
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Addiction Biology, Ahead of Print. (Source: Addiction Biology)
Source: Addiction Biology - September 25, 2017 Category: Addiction Source Type: research
Imaging the neuroimmune response to alcohol exposure in adolescent baboons: a TSPO PET study using 18F ‐DPA‐714
Abstract
The effects of acute alcohol exposure to the central nervous system are hypothesized to involve the innate immune system. The neuroimmune response to an initial and acute alcohol exposure was investigated using translocator protein 18 kDa (TSPO) PET imaging, a non‐invasive marker of glial activation, in adolescent baboons. Three different alcohol‐naive adolescent baboons (3–4 years old, 9 to 14 kg) underwent 18F‐DPA‐714 PET experiments before, during and 7–12 months after this initial alcohol exposure (0.7–1.0 g/l). The brain distribution of 18F‐DPA‐714 (VT; in ml/cm3) was estimated in sever...
Source: Addiction Biology - September 25, 2017 Category: Addiction Authors: Wadad Saba, S ébastien Goutal, Sylvain Auvity, Bertrand Kuhnast, Christine Coulon, Virginie Kouyoumdjian, Irène Buvat, Claire Leroy, Nicolas Tournier Tags: Original Article Source Type: research
