Sex differences in binge ‐like EtOH drinking, corticotropin‐releasing hormone and corticosterone: effects of β‐endorphin
Abstract
Binge drinking is an increasingly common pattern of risky use associated with numerous health problems, including alcohol use disorders. Because low basal plasma levels of β‐endorphin (β‐E) and an increased β‐E response to alcohol are evident in genetically at‐risk human populations, this peptide is thought to contribute to the susceptibility for disordered drinking. Animal models suggest that the effect of β‐E on consumption may be sex‐dependent. Here, we studied binge‐like EtOH consumption in transgenic mice possessing varying levels of β‐E: wild‐type controls with 100% of the peptide (β...
Source: Addiction Biology - January 1, 2018 Category: Addiction Authors: Todd B. Nentwig, Diane E. Wilson, Erin M. Rhinehart, Judith E. Grisel Tags: Original Article Source Type: research
Activation of amylin receptors attenuates alcohol ‐mediated behaviours in rodents
Abstract
Alcohol expresses its reinforcing properties by activating areas of the mesolimbic dopamine system, which consists of dopaminergic neurons projecting from the ventral tegmental area to the nucleus accumbens. The findings that reward induced by food and addictive drugs involve common mechanisms raise the possibility that gut–brain hormones, which control appetite, such as amylin, could be involved in reward regulation. Amylin decreases food intake, and despite its implication in the regulation of natural rewards, tenuous evidence support amylinergic mediation of artificial rewards, such as alcohol. Therefore, the...
Source: Addiction Biology - January 1, 2018 Category: Addiction Authors: Aimilia Lydia Kalafateli, Daniel Vall öf, Elisabet Jerlhag Tags: Original Article Source Type: research
Acupuncture inhibition of methamphetamine ‐induced behaviors, dopamine release and hyperthermia in the nucleus accumbens: mediation of group II mGluR
Abstract
Methamphetamine (METH) increases metabolic neuronal activity in the mesolimbic dopamine (DA) system and mediates the reinforcing effect. To explore the underlying mechanism of acupuncture intervention in reducing METH‐induced behaviors, we investigated the effect of acupuncture on locomotor activity, ultrasonic vocalizations, extracellular DA release in the nucleus accumbens (NAcs) using fast‐scan cyclic voltammetry and alterations of brain temperature (an indicator of local brain metabolic activity) produced by METH administration. When acupuncture was applied to HT7, but not TE4, both locomotor activity and ...
Source: Addiction Biology - January 1, 2018 Category: Addiction Authors: Nam Jun Kim, Yeonhee Ryu, Bong Hyo Lee, Suchan Chang, Yu Fan, Young S. Gwak, Chae Ha Yang, Kyle B. Bills, Scott C. Steffensen, Jin Suk Koo, Eun Young Jang, Hee Young Kim Tags: Original Article Source Type: research
Methamphetamine binge administration dose ‐dependently enhanced negative affect and voluntary drug consumption in rats following prolonged withdrawal: role of hippocampal FADD
Addiction Biology, EarlyView. (Source: Addiction Biology)
Source: Addiction Biology - December 28, 2017 Category: Addiction Source Type: research
Extinction and reinstatement of an operant responding maintained by food in different models of obesity
Addiction Biology,Volume 23, Issue 2, Page 544-555, March 2018. (Source: Addiction Biology)
Source: Addiction Biology - December 28, 2017 Category: Addiction Source Type: research
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Addiction Biology, Ahead of Print. (Source: Addiction Biology)
Source: Addiction Biology - December 28, 2017 Category: Addiction Source Type: research
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Addiction Biology,Volume 23, Issue 2, Page 544-555, March 2018. (Source: Addiction Biology)
Source: Addiction Biology - December 28, 2017 Category: Addiction Source Type: research
Rich club and reward network connectivity as endophenotypes for alcohol dependence: a diffusion tensor imaging study
Addiction Biology, EarlyView. (Source: Addiction Biology)
Source: Addiction Biology - December 27, 2017 Category: Addiction Source Type: research
Sex hormones in alcohol consumption: a systematic review of evidence
Addiction Biology, EarlyView. (Source: Addiction Biology)
Source: Addiction Biology - December 27, 2017 Category: Addiction Source Type: research
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Addiction Biology, Ahead of Print. (Source: Addiction Biology)
Source: Addiction Biology - December 27, 2017 Category: Addiction Source Type: research
Sex hormones in alcohol consumption: a systematic review of evidence
Abstract
Sex hormones play an important role in establishing sex‐distinctive brain structural and functional variations that could contribute to the sex differences in alcohol consumption behavior. Here, we systematically reviewed articles that studied sex hormone impacts on alcohol consumption and alcohol use disorder (AUD). An extensive literature search conducted in MEDLINE, PubMed, Scopus and CINAHL databases identified 776 articles, which were then evaluated for pre‐specified criteria for relevance and quality assurance. A total of 50 articles, including 19 human studies and 31 animal studies, were selected for th...
Source: Addiction Biology - December 27, 2017 Category: Addiction Authors: Almila Erol, Ada M. ‐C. Ho, Stacey J. Winham, Victor M. Karpyak Tags: Original Article Source Type: research
Rat brain CYP2D activity alters in vivo central oxycodone metabolism, levels and resulting analgesia
Addiction Biology, EarlyView. (Source: Addiction Biology)
Source: Addiction Biology - December 21, 2017 Category: Addiction Source Type: research
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Addiction Biology, Ahead of Print. (Source: Addiction Biology)
Source: Addiction Biology - December 21, 2017 Category: Addiction Source Type: research
Neurological, nutritional and alcohol consumption factors underlie cognitive and motor deficits in chronic alcoholism
Addiction Biology, EarlyView. (Source: Addiction Biology)
Source: Addiction Biology - December 15, 2017 Category: Addiction Source Type: research
