Red Bull ® energy drink increases consumption of higher concentrations of alcohol
Addiction Biology, EarlyView. (Source: Addiction Biology)
Source: Addiction Biology - September 22, 2017 Category: Addiction Source Type: research
Phosphorylation of calcium/calmodulin ‐dependent protein kinase II in the rat dorsal medial prefrontal cortex is associated with alcohol‐induced cognitive inflexibility
Addiction Biology, EarlyView. (Source: Addiction Biology)
Source: Addiction Biology - September 22, 2017 Category: Addiction Source Type: research
Time ‐dependent neuronal changes associated with craving in opioid dependence: an fMRI study
Addiction Biology, EarlyView. (Source: Addiction Biology)
Source: Addiction Biology - September 22, 2017 Category: Addiction Source Type: research
Amino acid modulation of dopamine in the nucleus accumbens mediates sex differences in nicotine withdrawal
Addiction Biology, EarlyView. (Source: Addiction Biology)
Source: Addiction Biology - September 22, 2017 Category: Addiction Source Type: research
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Addiction Biology, Ahead of Print. (Source: Addiction Biology)
Source: Addiction Biology - September 22, 2017 Category: Addiction Source Type: research
Association of contextual cues with morphine reward increases neural and synaptic plasticity in the ventral hippocampus of rats
In conclusion, we show that morphine‐induced reward‐related memory is associated with neural and synaptic plasticity changes in the ventral hippocampus. Such neural changes could underlie context‐induced drug relapse.
Increased number of Ki67 and DCX positive neurons in the ventral dentate gyrus was found in the morphine‐induced conditioned place preference. Dendritic spine density of the dentate gyrus granule cells and CA1 pyramidal neurons were significantly increased in CPP‐morphine group. BDNF and TrkB mRNA levels in the ventral hippocampus of CPP‐morphine group were increased. Ki67, DCX positive cells, an...
Source: Addiction Biology - September 22, 2017 Category: Addiction Authors: Mina Sadighi Alvandi, Maria Bourmpoula, Judith R. Homberg, Yaghoub Fathollahi Tags: Original Article Source Type: research
Phosphorylation of calcium/calmodulin ‐dependent protein kinase II in the rat dorsal medial prefrontal cortex is associated with alcohol‐induced cognitive inflexibility
Abstract
Repeated cycles of alcohol [ethanol (EtOH)] intoxication and withdrawal dysregulate excitatory glutamatergic systems in the brain and induce neuroadaptations in the medial prefrontal cortex (mPFC) that contribute to cognitive dysfunction. The mPFC is composed of subdivisions that are functionally distinct, with dorsal regions facilitating drug‐cue associations and ventral regions modulating new learning in the absence of drug. A key modulator of glutamatergic activity is the holoenzyme calcium/calmodulin‐dependent protein kinase II (CaMKII) that phosphorylates ionotropic glutamate receptors. Here, we examined ...
Source: Addiction Biology - September 22, 2017 Category: Addiction Authors: Luis A. Natividad, Michael Q. Steinman, Sarah A. Laredo, Cristina Irimia, Ilham Y. Polis, Robert Lintz, Matthew W. Buczynski, R émi Martin‐Fardon, Marisa Roberto, Loren H. Parsons Tags: Original Article Source Type: research
Time ‐dependent neuronal changes associated with craving in opioid dependence: an fMRI study
Abstract
Relapse after initially successful treatment is a significant problem facing the treatment of opioid dependence. Evidence suggests craving elicited by re‐exposure to drug cues may precipitate relapse. Attempts to identify neural biomarkers of cue‐elicited craving have yielded inconsistent findings. We aimed to apply a novel continuous functional magnetic resonance imaging technique to follow the minute‐to‐minute evolution of brain responses, which correlate with the waxing and waning of craving. Newly detoxified male opioid‐dependent patients and healthy control participants attended two separate, counte...
Source: Addiction Biology - September 22, 2017 Category: Addiction Authors: Anna Murphy, Dan I. Lubman, Shane McKie, Prun S. Bijral, Lesley A. Peters, Qasim Faiz, Sophie E. Holmes, Ian M. Anderson, Bill Deakin, Rebecca Elliott Tags: Original Article Source Type: research
Amino acid modulation of dopamine in the nucleus accumbens mediates sex differences in nicotine withdrawal
Abstract
The aversive effect of nicotine withdrawal is greater in female versus male rats, and we postulate that this sex difference is mediated in the nucleus accumbens (NAc). Nicotine withdrawal induces decreases in NAc dopamine and increases in acetylcholine (ACh) levels in male rats. To our knowledge, these neurochemical markers of nicotine withdrawal have not been compared in female versus male rats. Given the role of amino acids in modulating NAc dopaminergic and cholinergic transmission, concomitant measures of gamma‐aminobutyric acid (GABA) and glutamate levels were also compared across sex. Rats received continu...
Source: Addiction Biology - September 22, 2017 Category: Addiction Authors: Luis M. Carcoba, Rodolfo J. Flores, Luis A. Natividad, Laura E. O'Dell Tags: Special Issue Source Type: research
α6 subunit‐containing nicotinic receptors mediate low‐dose ethanol effects on ventral tegmental area neurons and ethanol reward
Addiction Biology, EarlyView. (Source: Addiction Biology)
Source: Addiction Biology - September 13, 2017 Category: Addiction Source Type: research
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Addiction Biology, Ahead of Print. (Source: Addiction Biology)
Source: Addiction Biology - September 13, 2017 Category: Addiction Source Type: research
Phosphorylated SNAP25 in the CA1 regulates morphine ‐associated contextual memory retrieval via increasing GluN2B‐NMDAR surface localization
Addiction Biology, EarlyView. (Source: Addiction Biology)
Source: Addiction Biology - September 8, 2017 Category: Addiction Source Type: research
