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Addiction Biology,Volume 23, Issue 2, Page 531-543, March 2018. (Source: Addiction Biology)
Source: Addiction Biology - January 10, 2018 Category: Addiction Source Type: research
Time ‐course and dynamics of obesity‐related behavioral changes induced by energy‐dense foods in mice
Abstract
Obesity represents an important risk factor contributing to the global burden of disease. The current obesogenic environment with easy access to calorie‐dense foods is fueling this obesity epidemic. However, how these foods contribute to the progression of feeding behavior changes that lead to overeating is not well understood and needs systematic assessment. Using novel automated methods for the high‐throughput screening of behavior, we here examine mice meal pattern upon long‐term exposure to a free‐choice chocolate‐mixture diet and a high‐fat diet with face validity for a rapid development of obesit...
Source: Addiction Biology - January 10, 2018 Category: Addiction Authors: Jose Espinosa ‐Carrasco, Aurelijus Burokas, Marta Fructuoso, Ionas Erb, Elena Martín‐García, Miriam Gutiérrez‐Martos, Cedric Notredame, Rafael Maldonado, Mara Dierssen Tags: Original Article Source Type: research
Beyond genome ‐wide significance: integrative approaches to the interpretation and extension of GWAS findings for alcohol use disorder
Addiction Biology, EarlyView. (Source: Addiction Biology)
Source: Addiction Biology - January 9, 2018 Category: Addiction Source Type: research
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Addiction Biology, Ahead of Print. (Source: Addiction Biology)
Source: Addiction Biology - January 9, 2018 Category: Addiction Source Type: research
Validation of a behavioral economic purchase task for assessing drug abuse liability
Addiction Biology, EarlyView. (Source: Addiction Biology)
Source: Addiction Biology - January 5, 2018 Category: Addiction Source Type: research
Chemogenetic inhibition of direct pathway striatal neurons normalizes pathological, cue ‐induced reinstatement of drug‐seeking in rats
Addiction Biology, EarlyView. (Source: Addiction Biology)
Source: Addiction Biology - January 5, 2018 Category: Addiction Source Type: research
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Addiction Biology, Ahead of Print. (Source: Addiction Biology)
Source: Addiction Biology - January 5, 2018 Category: Addiction Source Type: research
Chemogenetic inhibition of direct pathway striatal neurons normalizes pathological, cue ‐induced reinstatement of drug‐seeking in rats
Abstract
Addiction to drugs such as cocaine is marked by cycles of compulsive drug‐taking and drug‐seeking behavior. Although the transition to addiction is thought to recruit neural processes in dorsal striatum, little is known regarding the role of dorsal striatal projections to the substantia nigra (i.e. the direct pathway) in regulating these behaviors. Combining a Cre‐recombinase‐dependent chemogenetic approach with a cocaine self‐administration paradigm that produces both low‐risk and high‐risk addiction phenotypes, we examined the effect of transiently decreasing direct pathway activity in the dorsomed...
Source: Addiction Biology - January 5, 2018 Category: Addiction Authors: Lindsay M. Yager, Aaron F. Garcia, Elizabeth A. Donckels, Susan M. Ferguson Tags: Original Article Source Type: research
Appetitive to aversive counter ‐conditioning as intervention to reduce reinstatement of reward‐seeking behavior: the role of the serotonin transporter
Addiction Biology, EarlyView. (Source: Addiction Biology)
Source: Addiction Biology - January 2, 2018 Category: Addiction Source Type: research
Acute and chronic modulation of striatal endocannabinoid ‐mediated plasticity by nicotine
Addiction Biology, EarlyView. (Source: Addiction Biology)
Source: Addiction Biology - January 2, 2018 Category: Addiction Source Type: research
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Addiction Biology, Ahead of Print. (Source: Addiction Biology)
Source: Addiction Biology - January 2, 2018 Category: Addiction Source Type: research
Acute and chronic modulation of striatal endocannabinoid ‐mediated plasticity by nicotine
We report that nicotine differentially affects ex vivo eCB signaling depending on previous exposure in vivo. In the nicotine‐naïve brain, nicotine facilitates eCB‐signaling and LTD, whereas tolerance develops to this facilitating effect after subchronic exposure in vivo. In the end, a progressive impairment of eCB‐induced LTD is established after protracted withdrawal from nicotine. Endocannabinoid‐LTD is reinstated 6 months after the last drug injection, but a brief period of nicotine re‐exposure is sufficient to yet again impair eCB‐signaling. LTD induced by the cannabinoid 1 receptor agonist WIN55,212‐2 ...
Source: Addiction Biology - January 2, 2018 Category: Addiction Authors: Louise Adermark, Julia Morud, Amir Lotfi, Mia Ericson, Bo S öderpalm Tags: Original Article Source Type: research
Medial habenula cholinergic signaling regulates cocaine ‐associated relapse‐like behavior
In this study, we focus on the response of the MHb to reinstatement of cocaine‐associated behavior, demonstrating that cocaine‐primed reinstatement of conditioned place preference engages habenula circuitry. Using chemogenetics, we demonstrate that MHb activity is sufficient to induce reinstatement behavior. Together, these data identify the MHb as a key hub in the circuitry underlying reinstatement and may serve as a target for regulating relapse‐like behaviors.
The medial habenula is a region typically regarded as a mediator of aversion, anxiety‐like behaviors, and the aversive properties of nicotine. Here, we d...
Source: Addiction Biology - January 1, 2018 Category: Addiction Authors: Alberto J. L ópez, Yousheng Jia, André O. White, Janine L. Kwapis, Monica Espinoza, Philip Hwang, Rianne Campbell, Yasaman Alaghband, Om Chitnis, Dina P. Matheos, Gary Lynch, Marcelo A. Wood Tags: Original Article Source Type: research
