Mu opioid receptors in GABAergic neurons of the forebrain promote alcohol reward and drinking
Abstract
Mu opioid receptors (MORs) are widely distributed throughout brain reward circuits and their role in drug and social reward is well established. Substantial evidence has implicated MOR and the endogenous opioid system in alcohol reward, but circuit mechanisms of MOR‐mediated alcohol reward and intake behavior remain elusive, and have not been investigated by genetic approaches. We recently created conditional knockout (KO) mice targeting the Oprm1 gene in GABAergic forebrain neurons. These mice (Dlx‐MOR KO) show a major MOR deletion in the striatum, whereas receptors in midbrain (including the Ventral Tegmenta...
Source: Addiction Biology - November 1, 2017 Category: Addiction Authors: Sami Ben Hamida, Laura ‐Joy Boulos, Michael McNicholas, Pauline Charbogne, Brigitte Lina Kieffer Tags: Original Article Source Type: research
Problematic alcohol use associates with sodium channel and clathrin linker 1 (SCLT1) in trauma ‐exposed populations
We report results from a genome‐wide association study of alcohol consumption and associated problems as measured by the alcohol use disorders identification test (AUDIT) in a trauma‐exposed cohort. Results indicate a genome‐wide significant association between total AUDIT score and rs1433375 [N = 1036, P = 2.61 × 10−8 (dominant model), P = 7.76 × 10−8 (additive model)], an intergenic single‐nucleotide polymorphism located 323 kb upstream of the sodium channel and clathrin linker 1 (SCLT1) at 4q28. rs1433375 was also significant in a meta‐analysis of two similar, but independent, cohorts (N = 1...
Source: Addiction Biology - October 30, 2017 Category: Addiction Authors: Lynn M. Almli, Adriana Lori, Jacquelyn L. Meyers, Jaemin Shin, Negar Fani, Adam X. Maihofer, Caroline M. Nievergelt, Alicia K. Smith, Kristina B. Mercer, Kimberly Kerley, Jennifer M. Leveille, Hao Feng, Duna Abu ‐Amara, Janine D. Flory, Rachel Yehuda, C Tags: Original Article Source Type: research
Problematic alcohol use associates with sodium channel and clathrin linker 1 (SCLT1) in trauma ‐exposed populations
Addiction Biology, EarlyView. (Source: Addiction Biology)
Source: Addiction Biology - October 30, 2017 Category: Addiction Source Type: research
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Addiction Biology, Ahead of Print. (Source: Addiction Biology)
Source: Addiction Biology - October 30, 2017 Category: Addiction Source Type: research
Issue Information
No abstract is available for this article. (Source: Addiction Biology)
Source: Addiction Biology - October 27, 2017 Category: Addiction Tags: Issue Information Source Type: research
Inhibition of fatty acid amide hydrolase in the central amygdala alleviates co ‐morbid expression of innate anxiety and excessive alcohol intake
Addiction Biology, EarlyView. (Source: Addiction Biology)
Source: Addiction Biology - October 26, 2017 Category: Addiction Source Type: research
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Addiction Biology, Ahead of Print. (Source: Addiction Biology)
Source: Addiction Biology - October 26, 2017 Category: Addiction Source Type: research
Association of the alcohol dehydrogenase gene polymorphism rs1789891 with gray matter brain volume, alcohol consumption, alcohol craving and relapse risk
Addiction Biology, EarlyView. (Source: Addiction Biology)
Source: Addiction Biology - October 23, 2017 Category: Addiction Source Type: research
Orbitofrontal gray matter deficits as marker of Internet gaming disorder: converging evidence from a cross ‐sectional and prospective longitudinal design
Addiction Biology, EarlyView. (Source: Addiction Biology)
Source: Addiction Biology - October 23, 2017 Category: Addiction Source Type: research
Genome ‐wide association study of alcohol use disorder identification test (AUDIT) scores in 20 328 research participants of European ancestry
Addiction Biology, EarlyView. (Source: Addiction Biology)
Source: Addiction Biology - October 23, 2017 Category: Addiction Source Type: research
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Addiction Biology, Ahead of Print. (Source: Addiction Biology)
Source: Addiction Biology - October 23, 2017 Category: Addiction Source Type: research
Orbitofrontal gray matter deficits as marker of Internet gaming disorder: converging evidence from a cross ‐sectional and prospective longitudinal design
Abstract
Internet gaming disorder represents a growing health issue. Core symptoms include unsuccessful attempts to control the addictive patterns of behavior and continued use despite negative consequences indicating a loss of regulatory control. Previous studies revealed brain structural deficits in prefrontal regions subserving regulatory control in individuals with excessive Internet use. However, because of the cross‐sectional nature of these studies, it remains unknown whether the observed brain structural deficits preceded the onset of excessive Internet use. Against this background, the present study combined a c...
Source: Addiction Biology - October 23, 2017 Category: Addiction Authors: Feng Zhou, Christian Montag, Rayna Sariyska, Bernd Lachmann, Martin Reuter, Bernd Weber, Peter Trautner, Keith M. Kendrick, Sebastian Markett, Benjamin Becker Tags: Original Article Source Type: research
Activated mesenchymal stem cell administration inhibits chronic alcohol drinking and suppresses relapse ‐like drinking in high‐alcohol drinker rats
Addiction Biology, EarlyView. (Source: Addiction Biology)
Source: Addiction Biology - October 18, 2017 Category: Addiction Source Type: research
