Cocaine conditioned place preference: unexpected suppression of preference due to testing combined with strong conditioning

This study emphasizes the complex nature of CPP memory and the importance of multiple parameters that must be taken into consideration when investigating reconsolidation. Blockade of D1 receptors during reconditioning prevented extracellular signal‐regulated kinase activation and induced a loss of conditioned place preference (CPP). We also unexpectedly observed a CPP disappearance in mice that underwent testing and reconditioning with cocaine alone, specifically in strong conditioning conditions. Our data emphasize the complex nature of CPP memory and the importance of multiple parameters that must be taken into consideration when investigating reconsolidation.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2Fadb.12600

Source: Addiction Biology - November 1, 2017 Category: Addiction Authors: Lucile Marion ‐Poll, Antoine Besnard, Sophie Longueville, Emmanuel Valjent, Olivia Engmann, Jocelyne Caboche, Denis Hervé, Jean‐Antoine Girault Tags: Original Article Source Type: research