“On‐Droplet” Chemistry: The Cycloaddition of Diethyl Azodicarboxylate and Quadricyclane
Angewchem“On‐Droplet” Chemistry: The Cycloaddition of Diethyl Azodicarboxylate and Quadricyclane: Sharpless and co ‐workers previously studied the [2σ+2σ+2π] cycloaddition of diethyl azodicarboxylate (DEAD) and quadricyclane and reported that the addition of water to the neat reagents caused an acceleration... (Source: Organometallic Current)
Source: Organometallic Current - October 25, 2017 Category: Chemistry Tags: Cycloaddition Source Type: blogs
Experimental and Computational Study of an Unexpected Iron ‐Catalyzed Carboetherification by Cooperative Metal and Ligand Substrate Interaction and Proton Shuttling
AngewchemExperimental and Computational Study of an Unexpected Iron ‐Catalyzed Carboetherification by Cooperative Metal and Ligand Substrate Interaction and Proton Shuttling: An iron ‐catalyzed cycloisomerization of allenols to deoxygenated pyranose glycals has been developed. Combined experimental and computational studies show that the iron complex exhibits a dual catalytic... (Source: Organometallic Current)
Source: Organometallic Current - October 25, 2017 Category: Chemistry Tags: Carboetherification Fe catalyzed Source Type: blogs
Photoredox Generation of Carbon ‐Centered Radicals Enables the Construction of 1,1‐Difluoroalkene Carbonyl Mimics
AngewchemPhotoredox Generation of Carbon ‐Centered Radicals Enables the Construction of 1,1‐Difluoroalkene Carbonyl Mimics: Described is a facile, scalable route to access functional ‐group‐rich gem‐difluoroalkenes. Using visible‐light‐activated catalysts in conjunction with an arsenal of carbon‐radical precursors, an array... (Source: Organometallic Current)
Source: Organometallic Current - October 25, 2017 Category: Chemistry Tags: Photoredox Catalysis Source Type: blogs
Radical ‐Based C−C Bond‐Forming Processes Enabled by the Photoexcitation of 4‐Alkyl‐1,4‐dihydropyridines
We report herein that 4 ‐alkyl‐1,4‐dihydropyridines (alkyl‐DHPs) can directly reach an electronically excited state upon light absorption and trigger the generation of C(sp3)‐centered radicals without the... (Source: Organometallic Current)
Source: Organometallic Current - October 25, 2017 Category: Chemistry Tags: Ni Catalyzed Photoreaction Source Type: blogs
A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters
We report herein the use of a dual catalytic system comprising a Lewis base catalyst such as quinuclidin ‐3‐ol or 4‐dimethylaminopyridine and a photoredox catalyst to generate carbon radicals from either... (Source: Organometallic Current)
Source: Organometallic Current - October 25, 2017 Category: Chemistry Tags: Photoredox Catalysis Source Type: blogs
Catalytic Asymmetric [8 2] Annulation Reactions Promoted by a Recyclable Immobilized Isothiourea
AngewchemCatalytic Asymmetric [8 2] Annulation Reactions Promoted by a Recyclable Immobilized Isothiourea: Higher ‐order cycloaddition reactions constitute an efficient approach towards the construction of medium to large ring systems. However, enantioselective versions of these transformations remain scarce,... (Source: Organometallic Current)
Source: Organometallic Current - October 25, 2017 Category: Chemistry Tags: organocatalysis Source Type: blogs
Total Synthesis of Lycoricidine and Narciclasine by Chemical Dearomatization of Bromobenzene
AngewchemTotal Synthesis of Lycoricidine and Narciclasine by Chemical Dearomatization of Bromobenzene: The total synthesis of lycoricidine and narciclasine is enabled by an arenophile ‐mediated dearomative dihydroxylation of bromobenzene. Subsequent transpositive Suzuki coupling and cycloreversion deliver... (Source: Organometallic Current)
Source: Organometallic Current - October 25, 2017 Category: Chemistry Tags: Total synthesis Source Type: blogs
Nickel ‐Catalyzed N‐Alkylation of Acylhydrazines and Arylamines Using Alcohols and Enantioselective Examples
AngewchemNickel ‐Catalyzed N‐Alkylation of Acylhydrazines and Arylamines Using Alcohols and Enantioselective Examples: A borrowing ‐hydrogen reaction between amines and alcohols is an atom‐economic way to prepare alkylamines, ideally with water as the sole byproduct. Herein, nickel catalysts are used for direct N‐alkylation... (Source: Organometallic Current)
Source: Organometallic Current - October 23, 2017 Category: Chemistry Tags: Ni Catalyzed Transfer Hydrogenation Source Type: blogs
Copper ‐Catalyzed Synthesis and Applications of Yndiamides
AngewchemCopper ‐Catalyzed Synthesis and Applications of Yndiamides: The first synthetic route to yndiamides, a novel class of double aza ‐substituted alkyne, has been established by the copper(I)‐catalyzed cross‐coupling of 1,1‐dibromoenamides with nitrogen nucleophiles.... (Source: Organometallic Current)
Source: Organometallic Current - October 23, 2017 Category: Chemistry Tags: Cu catalyzed Source Type: blogs
Total Syntheses of the Isomeric Aglain Natural Products Foveoglin A and Perviridisin B: Selective Excited‐State Intramolecular Proton‐Transfer Photocycloaddition
AngewchemTotal Syntheses of the Isomeric Aglain Natural Products Foveoglin A and Perviridisin B: Selective Excited‐State Intramolecular Proton‐Transfer Photocycloaddition: Selective excited ‐state intramolecular proton‐transfer (ESIPT) photocycloaddition of 3‐hydroxyflavones with trans, trans‐1,4‐diphenyl‐1,3‐butadiene is described. Using this methodology, total syntheses... (Source: Organometallic Current)
Source: Organometallic Current - October 23, 2017 Category: Chemistry Tags: Total synthesis Source Type: blogs
Radical Heterocyclization and Heterocyclization Cascades Triggered by Electron Transfer to Amide ‐Type Carbonyl Compounds
AngewchemRadical Heterocyclization and Heterocyclization Cascades Triggered by Electron Transfer to Amide ‐Type Carbonyl Compounds: Radical heterocyclizations triggered by electron transfer to amide ‐type carbonyls, using SmI2‐H2O, provide straightforward access to bicyclic heterocyclic scaffolds containing bridgehead nitrogen centers.... (Source: Organometallic Current)
Source: Organometallic Current - October 23, 2017 Category: Chemistry Tags: Radical Cyclization Source Type: blogs
Asymmetric Intermolecular Heck Reaction of Propargylic Acetates and Cycloalkenes to Access Fused Cyclobutenes
AngewchemAsymmetric Intermolecular Heck Reaction of Propargylic Acetates and Cycloalkenes to Access Fused Cyclobutenes: An asymmetric Heck annulation of propargylic acetates with several types of cyclic olefins affords highly strained cyclobutenes in high enantioselectivity. (Source: Organometallic Current)
Source: Organometallic Current - October 23, 2017 Category: Chemistry Tags: Pd Catalyzed Source Type: blogs
Enantioselective Synthesis of Tetrahydropyrano[3,4 ‐b]indoles: Palladium(II)‐Catalyzed Aminopalladation/1,4‐Addition Sequence
AngewchemEnantioselective Synthesis of Tetrahydropyrano[3,4 ‐b]indoles: Palladium(II)‐Catalyzed Aminopalladation/1,4‐Addition Sequence: A novel palladium(II) ‐catalyzed cyclization of aniline‐tethered alkynyl cyclohexadienones is reported. This reaction offers an atom‐economical and redox‐neutral access to various cyclohexenone‐fused tetrahydropyrano[3,4‐b]indoles... (Source: Organometallic Current)
Source: Organometallic Current - October 23, 2017 Category: Chemistry Tags: Enantioselective Pd Catalyzed Source Type: blogs
(4 3) Cycloaddition Reactions of N ‐Alkyl Oxidopyridinium Ions
Angewchem(4 3) Cycloaddition Reactions of N ‐Alkyl Oxidopyridinium Ions: N ‐Methylation of methyl 5‐hydroxynicotinate followed by reaction with a diene in the presence of triethylamine afforded (4+3) cycloadducts in good to excellent yields. High regioselectivity was observed... (Source: Organometallic Current)
Source: Organometallic Current - October 23, 2017 Category: Chemistry Tags: Cycloaddition Source Type: blogs
Synthesis of Biphenylenes and Their Higher Homologues by Cyclization of Aryne Derivatives
AngewchemSynthesis of Biphenylenes and Their Higher Homologues by Cyclization of Aryne Derivatives: This investigation demonstrates that a series of biphenylenes can be easily prepared from their corresponding halobiphenyls by the cyclization of in situ generated 2′,3′‐didehydro‐2‐lithiobiphenyls at... (Source: Organometallic Current)
Source: Organometallic Current - October 23, 2017 Category: Chemistry Tags: Synthetic method Source Type: blogs
