Enantioselective Total Synthesis of 3 β‐Hydroxy‐7β‐kemp‐8(9)‐en‐6‐one, a Diterpene Isolated from Higher Termites
AngewchemEnantioselective Total Synthesis of 3 β‐Hydroxy‐7β‐kemp‐8(9)‐en‐6‐one, a Diterpene Isolated from Higher Termites: The first total synthesis of the title diterpene was accomplished starting from the Wieland –Miescher ketone. A diastereoselective sulfa‐Michael addition enabled the generation of the delicate β,γ‐unsaturated... (Source: Organometallic Current)
Source: Organometallic Current - November 21, 2017 Category: Chemistry Tags: Total synthesis Source Type: blogs

Cationic Nitrogen ‐Doped Helical Nanographenes
AngewchemCationic Nitrogen ‐Doped Helical Nanographenes: Herein, we report the design and synthesis of a series of novel cationic nitrogen ‐doped nanographenes (CNDNs) with nonplanar geometry and axial chirality. Single‐crystal X‐ray analysis reveals helical... (Source: Organometallic Current)
Source: Organometallic Current - November 21, 2017 Category: Chemistry Tags: PAHs Source Type: blogs

Review: Selected Copper ‐Based Reactions for C−N, C−O, C−S, and C−C Bond Formation
AngewchemSelected Copper ‐Based Reactions for C−N, C−O, C−S, and C−C Bond Formation: Metal ‐catalyzed cross‐coupling reactions belong to the most important transformations in organic synthesis. Copper catalysis has received great attention owing to the low toxicity and low cost of copper.... (Source: Organometallic Current)
Source: Organometallic Current - November 21, 2017 Category: Chemistry Tags: C-C Bond Forming C-N Bond Forming C-O Bond Forming C-S Bond Forming Cu catalyzed Reviews Source Type: blogs

Highly Regio- and Enantioselective Copper-Catalyzed Reductive Hydroxymethylation of Styrenes and 1,3-Dienes with CO2
JacsHighly Regio- and Enantioselective Copper-Catalyzed Reductive Hydroxymethylation of Styrenes and 1,3-Dienes with CO2:Herein, we report a highly regio- and enantioselective copper-catalyzed reductive hydroxymethylation of styrenes and 1,3-dienes with 1 atm of CO2. Diverse important chiral homobenzylic alcohols were readily prepared from styrenes. (Source: Organometallic Current)
Source: Organometallic Current - November 14, 2017 Category: Chemistry Tags: Cu catalyzed Enantioselective hydroxymethylation Source Type: blogs

Synthesis of Pyrrole ‐Fused Corannulenes: 1,3‐Dipolar Cycloaddition of Azomethine Ylides to Corannulene
AngewchemSynthesis of Pyrrole ‐Fused Corannulenes: 1,3‐Dipolar Cycloaddition of Azomethine Ylides to Corannulene: In the long history of corannulene chemistry, the 1,3 ‐dipolar cycloaddition to corannulene is unprecedented. Reported herein is the 1,3‐dipolar cycloaddition of a polycyclic aromatic azomethine ylide to... (Source: Organometallic Current)
Source: Organometallic Current - November 14, 2017 Category: Chemistry Tags: Cycloaddition Oxidative Rxn Source Type: blogs

Direct Aryl C −H Amination with Primary Amines using Organic Photoredox Catalysis
AngewchemDirect Aryl C −H Amination with Primary Amines using Organic Photoredox Catalysis: The direct catalytic C −H amination of arenes is a powerful synthetic strategy with useful applications in pharmaceuticals, agrochemicals, and materials chemistry. Despite the advances in catalytic C−H... (Source: Organometallic Current)
Source: Organometallic Current - November 14, 2017 Category: Chemistry Tags: C-H amination Photoredox Catalysis Source Type: blogs

Ynamide Preactivation Allows a Regio ‐ and Stereoselective Synthesis of α,β‐Disubstituted Enamides
AngewchemYnamide Preactivation Allows a Regio ‐ and Stereoselective Synthesis of α,β‐Disubstituted Enamides: A novel ynamide preactivation strategy enables the use of otherwise incompatible reagents and allows preparation of α,β‐disubstituted enamides with high regio‐ and stereoselectivity. Mechanistic analysis... (Source: Organometallic Current)
Source: Organometallic Current - November 14, 2017 Category: Chemistry Tags: Cross Coupling Synthetic method Source Type: blogs

Catalytic Hydroalkylation of Allenes
AngewchemCatalytic Hydroalkylation of Allenes: We have developed a catalytic method for the hydroalkylation of allenes using alkyl triflates as electrophiles and silane as a hydride source. The reaction has an excellent substrate scope and is compatible... (Source: Organometallic Current)
Source: Organometallic Current - November 14, 2017 Category: Chemistry Tags: Cu catalyzed Hydroalkylation Source Type: blogs

Lewis acid enhancement by hydrogen-bond donors for asymmetric catalysis
BySteven M. Banik,Anna Levina,Alan M. Hyde,Eric N. JacobsenScience10 Nov 2017 : 761-764A chiral amide activates a silicon-based Lewis acid for joint asymmetric catalysis.Molecular catalysts with two closely spaced nitrogen-hydrogen groups can act like a tweezer, activating a carbon center by latching onto a leaving group through double hydrogen bonding and then pulling it away. In the resultant ion pair, the shape of the catalyst can bias an ensuing reaction to favor just one of two possible mirror-image products. Baniket al. used this motif to activate a Lewis acid cocatalyst, pulling a leaving group off silicon instead o...
Source: Organometallic Current - November 10, 2017 Category: Chemistry Tags: Asymmetric Lewis acid catalysis Source Type: blogs

One-Shot Multiple Borylation toward BN-Doped Nanographenes
JacsOne-Shot Multiple Borylation toward BN-Doped Nanographenes: One-shot double, triple, and quadruple borylation reactions of triarylamines were developed through a judicious choice of boron source and Br ønsted base. With the aid of borylation reactions, a variety of BN-doped nanographenes were synthesized in two steps from commercially available starting materials. (Source: Organometallic Current)
Source: Organometallic Current - November 10, 2017 Category: Chemistry Tags: Advanced materials Borylation Pd Catalyzed Source Type: blogs

Remote Cooperative Group Strategy Enables Ligands for Accelerative Asymmetric Gold Catalysis
JacsRemote Cooperative Group Strategy Enables Ligands for Accelerative Asymmetric Gold Catalysis: An accelerative asymmetric gold catalysis is achieved for the first time via chiral ligand metal cooperation. An asymmetrically positioned remote amide group in the designed chiral binaphthyl-based ligand plays the essential role of a general base catalyst and selectively accelerates the cyclizations of 4-allen-1-ols into one prochiral allene face. (Source: Organometallic Current)
Source: Organometallic Current - November 9, 2017 Category: Chemistry Tags: Gold Catalysis Source Type: blogs

Chemoselective Intermolecular Cross-Enolate-Type Coupling of Amides
JacsChemoselective Intermolecular Cross-Enolate-Type Coupling of Amides: A new approach for the synthesis of 1,4-dicarbonyl compounds is reported. Chemoselective activation of amide carbonyl functionality and subsequent umpolungviaN-oxide addition generates an electrophilic enolonium species that can be coupled with a wide range of nucleophilic enolates. (Source: Organometallic Current)
Source: Organometallic Current - November 9, 2017 Category: Chemistry Tags: Chemoselective Cross Coupling Source Type: blogs

Versatile Alkylation of (Hetero)Aryl Iodides with Ketones via β-C(sp3)–H Activation
We report Pd(II)-catalyzed β-C(sp3) –H (hetero)arylation of a variety of ketones using a commercially available 2,2-dimethyl aminooxyacetic acid auxiliary. Facile installation and removal of the auxiliary as well as its superior scope for both ketones and (hetero)aryl iodides overcome the significant limitations of the previous ly reported β-C(sp3) –H arylation of ketones. (Source: Organometallic Current)
Source: Organometallic Current - November 9, 2017 Category: Chemistry Tags: Alkylation Pd Catalyzed sp3 C-H Activation Source Type: blogs

Diastereoselective C −H Bond Amination for Disubstituted Pyrrolidines
We report herein the improved diastereoselective synthesis of 2,5 ‐disubstituted pyrrolidines from aliphatic azides. Experimental and theoretical studies of the C−H amination reaction mediated by the iron... (Source: Organometallic Current)
Source: Organometallic Current - November 9, 2017 Category: Chemistry Tags: C-H amination Diastereoselective Fe catalyzed Source Type: blogs

Visible ‐Light‐Driven Palladium‐Catalyzed Radical Alkylation of C−H Bonds with Unactivated Alkyl Bromides
AngewchemVisible ‐Light‐Driven Palladium‐Catalyzed Radical Alkylation of C−H Bonds with Unactivated Alkyl Bromides: Reported herein is a novel visible ‐light photoredox system with Pd(PPh3)4 as the sole catalyst for the realization of the first direct cross‐coupling of C(sp3)−H bonds in N‐aryl tetrahydroisoquinolines... (Source: Organometallic Current)
Source: Organometallic Current - November 9, 2017 Category: Chemistry Tags: Alkylation Pd Catalyzed Visible light Source Type: blogs