Medium ‐Sized‐Ring Analogues of Dibenzodiazepines by a Conformationally Induced Smiles Ring Expansion
AngewchemMedium ‐Sized‐Ring Analogues of Dibenzodiazepines by a Conformationally Induced Smiles Ring Expansion: Analogues of dibenzodiazepines, in which the seven ‐membered nitrogen heterocycle is replaced by a 9–12‐membered ring, were made by an unactivated Smiles rearrangement of five‐ to eight‐membered heterocyclic... (Source: Organometallic Current)
Source: Organometallic Current - October 23, 2017 Category: Chemistry Tags: Ring Expansion Source Type: blogs
Asymmetric Cycloisomerization of o ‐Alkenyl‐N‐Methylanilines to Indolines by Iridium‐Catalyzed C(sp3)−H Addition to Carbon–Carbon Double Bonds
AngewchemAsymmetric Cycloisomerization of o ‐Alkenyl‐N‐Methylanilines to Indolines by Iridium‐Catalyzed C(sp3)−H Addition to Carbon–Carbon Double Bonds: Highly enantioselective cycloisomerization of N ‐methylanilines, bearing o‐alkenyl groups, into indolines is established. An iridium catalyst bearing a bidentate chiral diphosphine effectively promotes... (Source: Organometallic Current)
Source: Organometallic Current - October 23, 2017 Category: Chemistry Tags: Asymmetric Cycloisomerizatoon Ir catalyzed Source Type: blogs
Influence of Polyethylene Glycol Unit on Palladium ‐ and Nickel‐Catalyzed Ethylene Polymerization and Copolymerization
AngewchemInfluence of Polyethylene Glycol Unit on Palladium ‐ and Nickel‐Catalyzed Ethylene Polymerization and Copolymerization: The transition ‐metal‐catalyzed copolymerization of olefins with polar functionalized co‐monomers represents a major challenge in the field of olefin polymerization. It is extremely difficult to simultaneously... (Source: Organometallic Current)
Source: Organometallic Current - October 23, 2017 Category: Chemistry Tags: Ni Catalyzed Pd Catalyzed Polymerization Source Type: blogs
Stereoselective Direct Chlorination of Alkenyl MIDA Boronates: Divergent Synthesis of E and Z α‐Chloroalkenyl Boronates
AngewchemStereoselective Direct Chlorination of Alkenyl MIDA Boronates: Divergent Synthesis of E and Z α‐Chloroalkenyl Boronates: The individual molecules of α‐chloroalkenyl boronates include both an electrophilic C−Cl bond and a nucleophilic C−B bond, which makes them intriguing organic synthons. Reported herein is a stereodivergent... (Source: Organometallic Current)
Source: Organometallic Current - October 23, 2017 Category: Chemistry Tags: Chlorination Source Type: blogs
Fast, Efficient and Low E ‐Factor One‐Pot Palladium‐Catalyzed Cross‐Coupling of (Hetero)Arenes
AngewchemFast, Efficient and Low E ‐Factor One‐Pot Palladium‐Catalyzed Cross‐Coupling of (Hetero)Arenes: The homocoupling of aryl halides and the heterocoupling of aryl halides with either aryl bromides or arenes bearing an ortho ‐lithiation directing group are presented. The use of a Pd catalyst, in combination... (Source: Organometallic Current)
Source: Organometallic Current - October 23, 2017 Category: Chemistry Tags: Cross Coupling Pd Catalyzed Source Type: blogs
Biosynthesis of the Enterotoxic Pyrrolobenzodiazepine Natural Product Tilivalline
AngewchemBiosynthesis of the Enterotoxic Pyrrolobenzodiazepine Natural Product Tilivalline: The nonribosomal enterotoxin tilivalline was the first naturally occurring pyrrolobenzodiazepine to be linked to disease in the human intestine. Since the producing organism Klebsiella oxytoca is part... (Source: Organometallic Current)
Source: Organometallic Current - October 23, 2017 Category: Chemistry Tags: Biosynthesis Source Type: blogs
Oxidative Rearrangement Coupling Reaction for the Functionalization of Tetrahydro ‐β‐carbolines with Aromatic Amines
AngewchemOxidative Rearrangement Coupling Reaction for the Functionalization of Tetrahydro ‐β‐carbolines with Aromatic Amines: The observation of an unexpected oxidative rearrangement coupling reaction led to the development of a novel method for the efficient functionalization of tetrahydro ‐β‐carbolines (THβCs). The treatment... (Source: Organometallic Current)
Source: Organometallic Current - October 23, 2017 Category: Chemistry Tags: Ru catalyzed Source Type: blogs
Synthesis of Octaaryl Naphthalenes and Anthracenes with Different Substituents
AngewchemSynthesis of Octaaryl Naphthalenes and Anthracenes with Different Substituents: A synthesis of multiply arylated naphthalenes and anthracenes with eight different substituents has been accomplished. The key intermediates are tetraarylthiophene S ‐oxides, which are synthesized through... (Source: Organometallic Current)
Source: Organometallic Current - October 23, 2017 Category: Chemistry Tags: Cycloaddition Source Type: blogs
Cobalt versus Osmium: Control of Both trans and cis Selectivity in Construction of the EFG Rings of Pectenotoxin 4
AngewchemCobalt versus Osmium: Control of Both trans and cis Selectivity in Construction of the EFG Rings of Pectenotoxin 4: Catalytic oxidative cyclisation reactions have been employed for the synthesis of the E and F rings of the complex natural product target pectenotoxin 4. The choice of metal catalyst (cobalt‐ or osmium‐based)... (Source: Organometallic Current)
Source: Organometallic Current - October 23, 2017 Category: Chemistry Tags: Co catalyzed Natural products Source Type: blogs
Single and Twofold Metal ‐ and Reagent‐Free Anodic C−C Cross‐Coupling of Phenols with Thiophenes
AngewchemSingle and Twofold Metal ‐ and Reagent‐Free Anodic C−C Cross‐Coupling of Phenols with Thiophenes: The first electrochemical dehydrogenative C −C cross‐coupling of thiophenes with phenols has been realized. This sustainable and very simple to perform anodic coupling reaction enables access to two classes... (Source: Organometallic Current)
Source: Organometallic Current - October 23, 2017 Category: Chemistry Tags: Cross Coupling Electrochemical Source Type: blogs
Total Synthesis of ( −)‐Spiroleucettadine
AngewchemTotal Synthesis of ( −)‐Spiroleucettadine: One of a number of intriguing new alkaloids isolated from the Leucetta sp. sponge in 2004, spiroleucettadine displayed unique structural features on a restricted scaffold: a trans ‐fused 5,5‐bicyclic ring... (Source: Organometallic Current)
Source: Organometallic Current - October 23, 2017 Category: Chemistry Tags: Total synthesis Source Type: blogs
Understanding and Interrupting the Fischer Azaindolization Reaction
JacsUnderstanding and Interrupting the Fischer Azaindolization Reaction: Experimental and computational studies pertaining to the Fischer azaindolization reaction are reported. These studies explain why pyridylhydrazines are poorly reactive in Fischer indolization reactions, in addition to the origin of hydrazine substituent effects. Additionally, an interrupted variant of Fischer azaindolization methodology is disclosed, which provides a synthetic entryway into fused azaindoline scaffolds. (Source: Organometallic Current)
Source: Organometallic Current - October 13, 2017 Category: Chemistry Tags: Fischer indole Source Type: blogs
General, Auxiliary-Enabled Photoinduced Pd-Catalyzed Remote Desaturation of Aliphatic Alcohols
JacsGeneral, Auxiliary-Enabled Photoinduced Pd-Catalyzed Remote Desaturation of Aliphatic Alcohols: A general, efficient, and site-selective visible light-induced Pd-catalyzed remote desaturation of aliphatic alcohols into valuable allylic, homoallylic, and bis-homoallylic alcohols has been developed. This transformation operates via a hybrid Pd-radical mechanism, which synergistically combines the favorable features of radical approaches, such as a facile remote C –H HAT step, with that of transition-metal-catalyzed chemistry (selective β-hydrogen elimination step). (Source: Organometallic Current)
Source: Organometallic Current - October 13, 2017 Category: Chemistry Tags: Pd Catalyzed Photoreaction Visible light Source Type: blogs
Directed γ-C(sp3)–H Alkylation of Carboxylic Acid Derivatives through Visible Light Photoredox Catalysis
JacsDirected γ-C(sp3)–H Alkylation of Carboxylic Acid Derivatives through Visible Light Photoredox Catalysis: Visible light photoredox catalysis enables direct γ- C(sp3) –H alkylation of saturated aliphatic carbonyl compounds. Electron-deficient alkenes are used as the coupling partners in this reaction. Distinguished site selectivity is controlled by the predominant 1,5-hydrogen atom transfer of an amidyl radical generatedin situ. (Source: Organometallic Current)
Source: Organometallic Current - October 13, 2017 Category: Chemistry Tags: Alkylation Ir catalyzed Photoredox Catalysis Source Type: blogs
Anti-Markovnikov alkene oxidation by metal-oxo –mediated enzyme catalysis
ByStephan C. Hammer,Grzegorz Kubik,Ella Watkins,Shan Huang,Hannah Minges,Frances H. ArnoldScience13 Oct 2017 : 215-218Directed evolution modifies cytochrome P450 to catalyze an unnatural reaction that has bedeviled chemical catalysis.There has been a recent flurry of activity in modifying enzymes to conduct unnatural chemical reactions more cleanly or selectively than synthetic chemical catalysts. Hammeret al. now report application of a cytochrome P450 variant to an oxidation that has largely eluded efficient catalysis. They used directed evolution to mutate the enzyme so that it placed oxygen at the less substituted carb...
Source: Organometallic Current - October 13, 2017 Category: Chemistry Tags: Anti Morkovnikov Enzyme catalyzed Fe catalyzed oxidation Source Type: blogs
