Enantioselective Phosphine ‐Catalyzed Formal [4 4] Annulation of α,β‐Unsaturated Imines and Allene Ketones: Construction of Eight‐Membered Rings
AngewchemEnantioselective Phosphine ‐Catalyzed Formal [4 4] Annulation of α,β‐Unsaturated Imines and Allene Ketones: Construction of Eight‐Membered Rings: The first highly enantioselective phosphine ‐catalyzed formal [4+4] annulation has been developed. In the presence of amino‐acid‐derived phosphines, the unprecedented [4+4] annulations between benzofuran/indole‐derived... (Source: Organometallic Current)
Source: Organometallic Current - October 11, 2017 Category: Chemistry Tags: organocatalysis Phosphine catalyzed Source Type: blogs
Iridium ‐Catalyzed Direct C−H Amidation Polymerization: Step‐Growth Polymerization by C−N Bond Formation via C−H Activation to Give Fluorescent Polysulfonamides
We report a powerful strategy for activation of C −H bonds to produce polysulfonamides by an atom‐economical and green method using iridium‐catalyzed direct C−H amidation polymerization (DCAP). After screening... (Source: Organometallic Current)
Source: Organometallic Current - October 11, 2017 Category: Chemistry Tags: C-H Amidation Ir catalyzed Polymerization Source Type: blogs
Visible Light ‐Induced Room‐Temperature Heck Reaction of Functionalized Alkyl Halides with Vinyl Arenes/Heteroarenes
AngewchemVisible Light ‐Induced Room‐Temperature Heck Reaction of Functionalized Alkyl Halides with Vinyl Arenes/Heteroarenes: The first visible light ‐induced Pd‐catalyzed Heck reaction of α‐heteroatom substituted alkyl iodides and ‐bromides with vinyl arenes/heteroarenes has been developed. This transformation efficiently proceeds... (Source: Organometallic Current)
Source: Organometallic Current - October 11, 2017 Category: Chemistry Tags: Heck Reaction Room Temp Rxn Visible light Source Type: blogs
Fluorine Effects on Group Migration via a Rhodium(V) Nitrenoid Intermediate
AngewchemFluorine Effects on Group Migration via a Rhodium(V) Nitrenoid Intermediate: An unprecedented rhodium(III) ‐catalyzed hydroarylation of α,α‐difluoromethylene alkynes with N‐pivaloxyl aroylamides through sequential C−H activation and aryl migration is detailed herein. A large array... (Source: Organometallic Current)
Source: Organometallic Current - October 11, 2017 Category: Chemistry Tags: Rh Catalyzed Source Type: blogs
Cooperative Effects between Chiral Cpx –Iridium(III) Catalysts and Chiral Carboxylic Acids in Enantioselective C−H Amidations of Phosphine Oxides
AngewchemCooperative Effects between Chiral Cpx –Iridium(III) Catalysts and Chiral Carboxylic Acids in Enantioselective C−H Amidations of Phosphine Oxides: An enantioselective C −H amidation of phosphine oxides by using an iridium(III) catalyst bearing an atropchiral cyclopentadienyl (Cpx) ligand is reported. A very strong cooperative effect between the chiral... (Source: Organometallic Current)
Source: Organometallic Current - October 11, 2017 Category: Chemistry Tags: C-H Amidation Ir catalyzed Source Type: blogs
Asymmetric Iron ‐Catalyzed C−H Alkylation Enabled by Remote Ligand meta‐Substitution
AngewchemAsymmetric Iron ‐Catalyzed C−H Alkylation Enabled by Remote Ligand meta‐Substitution: Highly enantioselective iron ‐catalyzed C−H alkylations by inner‐sphere C−H activation were accomplished with ample scope. High levels of enantiocontrol proved viable through a novel ligand design that... (Source: Organometallic Current)
Source: Organometallic Current - October 11, 2017 Category: Chemistry Tags: Asymmetric C-H alkylation Fe catalyzed Source Type: blogs
Merging [2 2] Cycloaddition with Radical 1,4 ‐Addition: Metal‐Free Access to Functionalized Cyclobuta[a]naphthalen‐4‐ols
AngewchemMerging [2 2] Cycloaddition with Radical 1,4 ‐Addition: Metal‐Free Access to Functionalized Cyclobuta[a]naphthalen‐4‐ols: A metal ‐free [2+2] cycloaddition and 1,4‐addition sequence induced by S‐centered radicals has been achieved by treating benzene‐linked allene‐ynes with aryldiazonium tetrafluoroborates and DABCO‐bis(sulfur... (Source: Organometallic Current)
Source: Organometallic Current - October 11, 2017 Category: Chemistry Tags: annulation Cycloaddition Metal free Source Type: blogs
Hydrogen Transfer ‐Mediated α‐Functionalization of 1,8‐Naphthyridines by a Strategy Overcoming the Over‐Hydrogenation Barrier
AngewchemHydrogen Transfer ‐Mediated α‐Functionalization of 1,8‐Naphthyridines by a Strategy Overcoming the Over‐Hydrogenation Barrier: A general catalytic hydrogen transfer ‐mediated α‐functionalization of 1,8‐naphthyridines is reported for the first time that benefits from a hydrogen transfer‐mediated activation mode for non‐activated... (Source: Organometallic Current)
Source: Organometallic Current - October 11, 2017 Category: Chemistry Tags: Ir catalyzed Transfer Hydrogenation Source Type: blogs
Synthesis and Utilization of Nitroalkyne Equivalents in Batch and Continuous Flow
We report a method for overcoming the low stability of nitroalkynes through the development of nitrated vinyl silyltriflate equivalents. Because of their instability, nitroalkynes have only rarely been... (Source: Organometallic Current)
Source: Organometallic Current - October 11, 2017 Category: Chemistry Tags: Heterocycles Source Type: blogs
Regioselective Intermolecular Allylic C −H Amination of Disubstituted Olefins via Rhodium/π‐Allyl Intermediates
AngewchemRegioselective Intermolecular Allylic C −H Amination of Disubstituted Olefins via Rhodium/π‐Allyl Intermediates: A method for catalytic intermolecular allylic C −H amination of trans‐disubstituted olefins is reported. The reaction is efficient for a range of common nitrogen nucleophiles bearing one electron‐withdrawing... (Source: Organometallic Current)
Source: Organometallic Current - October 11, 2017 Category: Chemistry Tags: Allylic C-H amination Rh Catalyzed Source Type: blogs
Reductive Coupling of Acrylates with Ketones and Ketimines by a Nickel ‐Catalyzed Transfer‐Hydrogenative Strategy
AngewchemReductive Coupling of Acrylates with Ketones and Ketimines by a Nickel ‐Catalyzed Transfer‐Hydrogenative Strategy: Nickel ‐catalyzed coupling of benzyl acrylates with activated ketones and imines provides γ‐butyrolactones and lactams, respectively. The benzyl alcohol byproduct released during the lactonization/lactamization... (Source: Organometallic Current)
Source: Organometallic Current - October 11, 2017 Category: Chemistry Tags: Ni Catalyzed Transfer Hydrogenation Source Type: blogs
Multidimensional Correlations in Asymmetric Catalysis through Parameterization of Uncatalyzed Transition States
AngewchemMultidimensional Correlations in Asymmetric Catalysis through Parameterization of Uncatalyzed Transition States: The study of the oxidative amination of tetrahydroisoquinolines under chiral ‐anion phase‐transfer (CAPT) catalysis by multidimensional correlation analysis (MCA) is revisited. The parameterization of the... (Source: Organometallic Current)
Source: Organometallic Current - October 11, 2017 Category: Chemistry Tags: Asymmetric chiral organocatalysis Source Type: blogs
Asymmetric Total Syntheses of Communesin F and a Putative Member of the Communesin Family
AngewchemAsymmetric Total Syntheses of Communesin F and a Putative Member of the Communesin Family: Here we report asymmetric total syntheses of communesin F and a putative member of the communesin family of bis‐aminal alkaloid natural products. The successful strategy featured the invention of an asymmetric... (Source: Organometallic Current)
Source: Organometallic Current - October 11, 2017 Category: Chemistry Tags: Total synthesis Source Type: blogs
Organocatalytic Enantioselective Protonation for Photoreduction of Activated Ketones and Ketimines Induced by Visible Light
AngewchemOrganocatalytic Enantioselective Protonation for Photoreduction of Activated Ketones and Ketimines Induced by Visible Light: The first catalytic asymmetric photoreduction of 1,2 ‐diketones and α‐keto ketimines under visible light irradiation is reported. A transition‐metal‐free synergistic catalysis platform harnessing dicyanopyrazine‐derived... (Source: Organometallic Current)
Source: Organometallic Current - October 11, 2017 Category: Chemistry Tags: organocatalysis Visible light Source Type: blogs
Rapid Assembly of Diversely Functionalized Spiroindenes by a Three ‐Component Palladium‐Catalyzed C−H Amination/Phenol Dearomatization Domino Reaction
AngewchemRapid Assembly of Diversely Functionalized Spiroindenes by a Three ‐Component Palladium‐Catalyzed C−H Amination/Phenol Dearomatization Domino Reaction: A novel palladium ‐catalyzed three‐component reaction of phenol‐derived biaryls with N‐benzoyloxyamines and norbornadiene (NBD) has been developed for the assembly of highly functionalized spiroindenes.... (Source: Organometallic Current)
Source: Organometallic Current - October 11, 2017 Category: Chemistry Tags: C-H amination Dearomatization Multicomponent Rxn Pd Catalyzed Source Type: blogs
