Catalytic C(sp3) –H Alkylation via an Iron Carbene Intermediate
JacsCatalytic C(sp3) –H Alkylation via an Iron Carbene Intermediate: The catalytic transformation of a C(sp3) –H bond to a C(sp3) –C bond via an iron carbene intermediate represents a long-standing challenge. Despite the success of enzymatic and small molecule iron catalysts mediating challenging C(sp3) –H oxidations and aminations via high-valent iron oxos and nitrenes, C(sp3) –H alkylations via isoelectronic iron carbene intermediates have thus far been unsuccessful. Iron carbenes have been inert, or shown to favor olefin cyclopropanation and heteroatom-hydrogen insertion. Herein we report an iron phthalocyanin...
Source: Organometallic Current - September 25, 2017 Category: Chemistry Tags: C-H alkylation Fe catalyzed Source Type: blogs
Enantioselective Synthesis of Cyclobutenes by Intermolecular [2 2] Cycloaddition with Non-C2 Symmetric Digold Catalysts
JacsEnantioselective Synthesis of Cyclobutenes by Intermolecular [2 2] Cycloaddition with Non-C2 Symmetric Digold Catalysts: The enantioselective intermolecular gold(I)-catalyzed [2+2] cycloaddition of terminal alkynes and alkenes has been achieved using non-C2-chiral Josiphos digold(I) complexes as catalysts, by the formation of the monocationic complex. This new approach has been applied to the enantioselective total synthesis of rumphellaone A. (Source: Organometallic Current)
Source: Organometallic Current - September 25, 2017 Category: Chemistry Tags: Enantioselective Gold Catalysis Source Type: blogs
Intermolecular Radical Addition to Carbonyls Enabled by Visible Light Photoredox Initiated Hole Catalysis
JacsIntermolecular Radical Addition to Carbonyls Enabled by Visible Light Photoredox Initiated Hole Catalysis: Herein, we present a novel strategy for the utilization of simple carbonyl compounds, aldehydes and ketones, as intermolecular radical acceptors. The reaction is enabled by visible light photoredox initiated hole catalysis and thein situ Br ønsted acid activation of the carbonyl compound. (Source: Organometallic Current)
Source: Organometallic Current - September 25, 2017 Category: Chemistry Tags: Photoredox Catalysis Visible light Source Type: blogs
Branched-Selective Intermolecular Ketone α-Alkylation with Unactivated Alkenes via an Enamide Directing Strategy
We describe a strategy for intermolecular branched-selective α-alkylation of ketones using simple alkenes as the alkylating agents. Enamides derived from isoindolin-1-one provide an excellent directing template for catalytic activation of ketone α-positions. (Source: Organometallic Current)
Source: Organometallic Current - September 25, 2017 Category: Chemistry Tags: Alkylation Ir catalyzed Source Type: blogs
Total Synthesis of ( −)-Nahuoic Acid Ci (Bii)
: A convergent total synthesis of ( −)-nahuoic acid Ci(Bii) (3), a novelcis-decalin polyketide, has been achieved. Key synthetic transformations include Type II Anion Relay Chemistry (ARC) to construct the polyol chain, a Ti-catalyzed asymmetric Diels –Alder reaction to generate thecis-decalin skeleton, and a late-stage large fragment union exploiting a Micalizio alkoxide-directed alkyne –alkene coupling tactic. (Source: Organometallic Current)
Source: Organometallic Current - September 25, 2017 Category: Chemistry Tags: Total synthesis Source Type: blogs
