Asymmetric Traceless Petasis Borono ‐Mannich Reactions of Enals: Reductive Transposition of Allylic Diazenes
AngewchemAsymmetric Traceless Petasis Borono ‐Mannich Reactions of Enals: Reductive Transposition of Allylic Diazenes: The traceless Petasis borono ‐Mannich reaction of enals, sulfonylhydrazines, and allylboronates, catalyzed by chiral biphenols, results in an asymmetric reductive transposition of the in situ generated... (Source: Organometallic Current)
Source: Organometallic Current - December 4, 2017 Category: Chemistry Tags: Asymmetric Mannich Reaction Source Type: blogs
Unlocking the Potential of Poly(Ortho Ester)s: A General Catalytic Approach to the Synthesis of Surface ‐Erodible Materials
AngewchemUnlocking the Potential of Poly(Ortho Ester)s: A General Catalytic Approach to the Synthesis of Surface ‐Erodible Materials: Poly(ortho ester)s (POEs) are well ‐known for their surface‐eroding properties and hence present unique opportunities for controlled‐release and tissue‐engineering applications. Their development and wide‐spread... (Source: Organometallic Current)
Source: Organometallic Current - December 4, 2017 Category: Chemistry Tags: Polymerization Ru catalyzed Source Type: blogs
Asymmetric Imine Hydroboration Catalyzed by Chiral Diazaphospholenes
AngewchemAsymmetric Imine Hydroboration Catalyzed by Chiral Diazaphospholenes: The first use of diazaphospholenes as chiral catalysts has been demonstrated with enantioselective imine hydroboration. A chiral diazaphospholene prepared in a simple three ‐step synthesis from commercial... (Source: Organometallic Current)
Source: Organometallic Current - December 4, 2017 Category: Chemistry Tags: Asymmetric Hydroboration Phosphine catalyzed Source Type: blogs
Radical Cyclization of Alkene ‐Tethered Ketones Initiated by Hydrogen‐Atom Transfer
AngewchemRadical Cyclization of Alkene ‐Tethered Ketones Initiated by Hydrogen‐Atom Transfer: An unprecedented C −C coupling reaction between alkenes and ketones by hydrogen‐atom transfer, using Fe(acac)3 and PhSiH3 in EtOH, is described. This mild protocol features high site selectivity and allows... (Source: Organometallic Current)
Source: Organometallic Current - December 4, 2017 Category: Chemistry Tags: Radical Cyclization Source Type: blogs
Photoinduced Remote Functionalisations by Iminyl Radical Promoted C −C and C−H Bond Cleavage Cascades
AngewchemPhotoinduced Remote Functionalisations by Iminyl Radical Promoted C −C and C−H Bond Cleavage Cascades: A photoinduced cascade strategy leading to a variety of differentially functionalised nitriles and ketones has been developed. These reactions rely on the oxidative generation of iminyl radicals from simple... (Source: Organometallic Current)
Source: Organometallic Current - December 4, 2017 Category: Chemistry Tags: C-C Bond Cleavage Photocatalysis Source Type: blogs
Organocatalyzed Photocontrolled Radical Polymerization of Semifluorinated (Meth)acrylates Driven by Visible Light
AngewchemOrganocatalyzed Photocontrolled Radical Polymerization of Semifluorinated (Meth)acrylates Driven by Visible Light: Fluorinated polymers are important materials that are widely used in many areas. Herein, we report the development of a metal ‐free photocontrolled radical polymerization of semifluorinated (meth)acrylates... (Source: Organometallic Current)
Source: Organometallic Current - December 4, 2017 Category: Chemistry Tags: organocatalysis Polymerization Source Type: blogs
Total Syntheses of the Monoterpenoid Indole Alkaloids ( ±)‐Alstoscholarisine B and C
AngewchemTotal Syntheses of the Monoterpenoid Indole Alkaloids ( ±)‐Alstoscholarisine B and C: Total syntheses of the monoterpenoid indole alkaloids ( ±)‐alstoscholarisine B and C were accomplished starting from a readily available indole‐2‐acetic ester and an α,β‐unsaturated N‐sulfonyllactam. (Source: Organometallic Current)
Source: Organometallic Current - December 4, 2017 Category: Chemistry Tags: Total synthesis Source Type: blogs
Reaction of Thiocarbonyl Fluoride Generated from Difluorocarbene with Amines
AngewchemReaction of Thiocarbonyl Fluoride Generated from Difluorocarbene with Amines: The reaction of thiocarbonyl fluoride, generated from difluorocarbene, with various amines under mild conditions is described. Secondary amines, primary amines, and o ‐phenylenediamines are converted to... (Source: Organometallic Current)
Source: Organometallic Current - December 1, 2017 Category: Chemistry Tags: Fluoroalkylation Synthetic method Trifluoromethylation Source Type: blogs
Thioamide ‐Directed Cobalt(III)‐Catalyzed Selective Amidation of C(sp3)−H Bonds
AngewchemThioamide ‐Directed Cobalt(III)‐Catalyzed Selective Amidation of C(sp3)−H Bonds: A mild, oxidant ‐free, and selective Cp*CoIII‐catalyzed amidation of thioamides with robust dioxazolone amidating agents via C(sp3)−H bond activation to generate the desired amidated products is reported.... (Source: Organometallic Current)
Source: Organometallic Current - December 1, 2017 Category: Chemistry Tags: Amidation Co catalyzed Sp3 Functionalization Source Type: blogs
Selective Functionalization of Aromatic C(sp2) −H Bonds in the Presence of Benzylic C(sp3)−H Bonds by Electron‐Deficient Carbenoids Generated from 4‐Acyl‐1‐Sulfonyl‐1,2,3‐Triazoles
AngewchemSelective Functionalization of Aromatic C(sp2) −H Bonds in the Presence of Benzylic C(sp3)−H Bonds by Electron‐Deficient Carbenoids Generated from 4‐Acyl‐1‐Sulfonyl‐1,2,3‐Triazoles: A rhodium(II) ‐catalyzed reaction of newly prepared 4‐acyl‐1‐sulfonyl‐1,2,3‐triazoles with benzene, and its derivatives, is investigated. Acceptor/acceptor carbenoids generated from 4‐acyltriazoles undergo... (Source: Organometallic Current)
Source: Organometallic Current - December 1, 2017 Category: Chemistry Tags: Rh Catalyzed Source Type: blogs
Photoredox-catalyzed deuteration and tritiation of pharmaceutical compounds
ByYong Yao Loh,Kazunori Nagao,Andrew J. Hoover,David Hesk,Nelo R. Rivera,Steven L. Colletti,Ian W. Davies,David W. C. MacMillanScience01 Dec 2017 : 1182-1187A light-promoted atom transfer protocol uses heavy water to isotopically label alkyl sites for drug metabolism studies.Deuterium- and tritium-labeled pharmaceutical compounds are pivotal diagnostic tools in drug discovery research, providing vital information about the biological fate of drugs and drug metabolites. Herein we demonstrate that a photoredox-mediated hydrogen atom transfer protocol can efficiently and selectively install deuterium (D) and tritium (T) at α...
Source: Organometallic Current - December 1, 2017 Category: Chemistry Tags: Deuteration Photoredox Catalysis Source Type: blogs
Organocalcium-mediated nucleophilic alkylation of benzene
ByAndrew S. S. Wilson,Michael S. Hill,Mary F. Mahon,Chiara Dinoi,Laurent MaronScience01 Dec 2017 : 1168-1171Alkyl calcium compounds can forge a carbon-carbon bond with benzene by displacing a hydride.The electrophilic aromatic substitution of a C –H bond of benzene is one of the archetypal transformations of organic chemistry. In contrast, the electron-rich π-system of benzene is highly resistant to reactions with electron-rich and negatively charged organic nucleophiles. Here, we report that this previously insurmountable electronic repulsion may be overcome through the use of sufficiently potent organocalcium nucleoph...
Source: Organometallic Current - December 1, 2017 Category: Chemistry Tags: Alkylation Ca Catalyzed Nucleophilic Substitution Source Type: blogs
Mild oxidation of methane to methanol or acetic acid on supported isolated rhodium catalysts
Junjun Shan, Mengwei Li, Lawrence F. Allard, Sungsik Lee& Maria Flytzani-StephanopoulosNature 551, 605 –608 (30 November 2017)doi:10.1038/nature24640Single-site isolated rhodium species anchored on zeolites or titanium dioxide are shown to catalyse the direct conversion of methane to methanol and acetic acid, using oxygen and carbon monoxide under mild conditions. (Source: Organometallic Current)
Source: Organometallic Current - November 30, 2017 Category: Chemistry Tags: oxidation Rh Catalyzed Source Type: blogs
Site-selective and stereoselective functionalization of non-activated tertiary C –H bonds
Kuangbiao Liao, Thomas C. Pickel, Vyacheslav Boyarskikh, John Bacsa, Djamaladdin G. Musaev + et al.Nature 551, 609 –613 (30 November 2017)doi:10.1038/nature24641The functionalization of specific inert C –H bonds avoids the need for functional groups in organic synthesis and here the challenges of this approach are overcome using a dirhodium catalyst that is capable of C–H bond site-selectivity. (Source: Organometallic Current)
Source: Organometallic Current - November 30, 2017 Category: Chemistry Tags: C-H Functionalization Rh Catalyzed Source Type: blogs
Electrochemical Cobalt-Catalyzed C –H Oxygenation at Room Temperature
JacsElectrochemical Cobalt-Catalyzed C –H Oxygenation at Room Temperature: Electrochemical cobalt-catalyzed C –H functionalizations were achieved in terms of C–H oxygenation under mild conditions at 23 °C. The robust electrochemical C–H functionalization was characterized by ample substrate scope, whereas mechanistic studies provided support for a facile C–H cleavage. (Source: Organometallic Current)
Source: Organometallic Current - November 29, 2017 Category: Chemistry Tags: C-H Oxygenation Co catalyzed Electrochemical Source Type: blogs
