Understanding the role of circulating chemokine (C-C motif) ligand 2 in patients with chronic ischemia threatening the lower extremities
The role of chemokine (C-C motif) ligand 2 (CCL2) in peripheral artery disease is unclear. We measured the difference between serum and plasma levels of CCL2 in patients with chronic ischemia threatening the lower extremities following the observation that atypical chemokine receptors in blood and tissue cells may prevent CCL2 from entering the circulation and consequently modulate its function of attracting monocytes to the site of lesion. To identify the influence of CCL2, we compared the patients’ values to those in bio-banked samples from a control population. Further, we explored the association with the Asp42Gl...
Source: Vascular Medicine - November 30, 2014 Category: Internal Medicine Authors: Rull, A., Hernandez-Aguilera, A., Fibla, M., Sepulveda, J., Rodriguez-Gallego, E., Riera-Borrull, M., Sirvent, J. J., Martin-Paredero, V., Menendez, J. A., Camps, J., Joven, J. Tags: Original Articles Source Type: research
Loss of endothelial-ARNT in adult mice contributes to dampened circulating proangiogenic cells and delayed wound healing
We report here that conditional inactivation of hypoxia-inducible factor’s (HIF) transcriptional activity in the endothelium of adult mice (ArntiEC mice) results in a disturbance of infiltrating cells, a hallmark of neoangiogenesis, during the early phases of wound healing. Cutaneous biopsy punches show distinct migration of CD31+ cells into wounds of control mice by 36 hours. However, a significant decline in numbers of infiltrating cells with immature vascular markers, as well as decreased transcript levels of genes associated with their expression and recruitment, were identified in wounds of Arnt...
Source: Vascular Medicine - November 30, 2014 Category: Internal Medicine Authors: Han, Y., Tao, J., Gomer, A., Ramirez-Bergeron, D. L. Tags: Original Articles Source Type: research
Elections for the Society for Vascular Medicine
(Source: Vascular Medicine recent issues)
Source: Vascular Medicine recent issues - October 10, 2014 Category: Internal Medicine Tags: Society for Vascular Medicine Communication Page Source Type: research
Vascular Disease Patient Information Page: Abdominal aortic aneurysm (AAA)
(Source: Vascular Medicine recent issues)
Source: Vascular Medicine recent issues - October 10, 2014 Category: Internal Medicine Authors: Moennich, L. A., Mastracci, T. M. Tags: Vascular Disease Patient Information Page Source Type: research
External iliac artery endofibrosis in an amateur runner
(Source: Vascular Medicine recent issues)
Source: Vascular Medicine recent issues - October 10, 2014 Category: Internal Medicine Authors: Green, B. L., Bailey, M. A., Bridge, K. I., Scott, D. J. A. Tags: Images in Vascular Medicine Source Type: research
Twenty-eight years later: A case of superior vena cava aneurysm secondary to cystic hygroma
(Source: Vascular Medicine recent issues)
Source: Vascular Medicine recent issues - October 10, 2014 Category: Internal Medicine Authors: Haddad, R. A., Jouni, H., Geske, J. B. Tags: Images in Vascular Medicine Source Type: research
Nicolau livedoid dermatitis occurring after sclerotherapy
(Source: Vascular Medicine recent issues)
Source: Vascular Medicine recent issues - October 10, 2014 Category: Internal Medicine Authors: Korkomaz, J., Maatouk, I., Moutran, R., Helou, J. Tags: Images in Vascular Medicine Source Type: research
Retroperitoneal fibrosis
(RPF) is a rare disease that is marked by systemic inflammation and the development of a periaortic fibroinflammatory mass. The fibroinflammatory infiltration can encase the abdominal aorta, ureters, and other abdominal organs. The clinical presentation often includes constitutional symptoms, abdominal pain, and signs of renal insufficiency or renal failure related to ureteral obstruction. Less frequently, RPF may present with vascular complications, such as venous thrombosis or claudication. The idiopathic form of RPF is most common but secondary forms have been described and are associated with malignancy and a variety ...
Source: Vascular Medicine recent issues - October 10, 2014 Category: Internal Medicine Authors: Tzou, M., Gazeley, D. J., Mason, P. J. Tags: Reviews Source Type: research
Design and utilization of macrophage and vascular smooth muscle cell co-culture systems in atherosclerotic cardiovascular disease investigation
Atherosclerotic cardiovascular disease has been acknowledged as a chronic inflammatory condition. Monocytes and macrophages lead the inflammatory pathology of atherosclerosis whereas changes in atheromatous plaque thickness and matrix composition are attributed to vascular smooth muscle cells. Because these cell types are key players in atherosclerosis progression, it is crucial to utilize a reliable system to investigate their interaction. In vitro co-culture systems are useful platforms to study specific molecular mechanisms between cells. This review aims to summarize the various co-culture models that have been develop...
Source: Vascular Medicine recent issues - October 10, 2014 Category: Internal Medicine Authors: Zuniga, M. C., White, S. L. P., Zhou, W. Tags: Reviews Source Type: research
Science of health care delivery: Re: Venous thromboembolism in hospitalized patients: An updated analysis of missed opportunities for thromboprophylaxis at a university affiliated tertiary care center
(Source: Vascular Medicine recent issues)
Source: Vascular Medicine recent issues - October 10, 2014 Category: Internal Medicine Authors: McBane, R. Tags: Editorial Source Type: research
Venous thromboembolism in hospitalized patients: An updated analysis of missed opportunities for thromboprophylaxis at a university-affiliated tertiary care center
In conclusion, we demonstrate a lower frequency of potentially preventable cases in 2010 compared to 2001 (39.3% vs 67.7%, respectively), partially due to physician education and adoption of an institution-wide policy. However, patients with medical indications for thromboprophylaxis, particularly those with cancer, are more prone to having preventable VTE, indicating an area for potential improvement. (Source: Vascular Medicine recent issues)
Source: Vascular Medicine recent issues - October 10, 2014 Category: Internal Medicine Authors: Ma, K. A., Cohen, E., Kahn, S. R. Tags: Original Articles Source Type: research
Accreditation status and geographic location of outpatient vascular testing facilities among Medicare beneficiaries: The VALUE (Vascular Accreditation, Location & Utilization Evaluation) Study
Conclusions:
Findings suggest that the proportion of outpatient vascular testing facilities that are IAC accredited is low and varies by region. Increasing the number of accredited vascular testing facilities to improve test quality is a hypothesis that should be tested in future research. (Source: Vascular Medicine recent issues)
Source: Vascular Medicine recent issues - October 10, 2014 Category: Internal Medicine Authors: Rundek, T., Brown, S. C., Wang, K., Dong, C., Farrell, M. B., Heller, G. V., Gornik, H. L., Hutchisson, M., Needleman, L., Benenati, J. F., Jaff, M. R., Meier, G. H., Perese, S., Bendick, P., Hamburg, N. M., Lohr, J. M., LaPerna, L., Leers, S. A., Lilly, Tags: Original Articles Source Type: research
Quality of care among patients undergoing lower extremity revascularization
Conclusions:
Although adherence to guidelines improved over time, we found a significant gap between guidelines and practice for this cohort of patients at increased risk for adverse cardiovascular events. (Source: Vascular Medicine recent issues)
Source: Vascular Medicine recent issues - October 10, 2014 Category: Internal Medicine Authors: Slovut, D. P., Kargoli, F., Fletcher, J. J., Etkin, Y., Lipsitz, E. C. Tags: Original Articles Source Type: research
Is fibromuscular dysplasia underdiagnosed? A comparison of the prevalence of FMD seen in CORAL trial participants versus a single institution population of renal donor candidates
In conclusion, the 5.8% prevalence of renal artery FMD in the CORAL trial population, the presence of which was biased against, suggests underdiagnosis. (Source: Vascular Medicine recent issues)
Source: Vascular Medicine recent issues - October 10, 2014 Category: Internal Medicine Authors: Hendricks, N. J., Matsumoto, A. H., Angle, J. F., Baheti, A., Sabri, S. S., Park, A. W., Stone, J. R., Patrie, J. T., Dworkin, L., Cooper, C. J., Murphy, T. P., Cutlip, D. E. Tags: Original Articles Source Type: research
The S curve: A novel morphological finding in the internal carotid artery in patients with fibromuscular dysplasia
In conclusion, the S curve is a novel morphological pattern of the mid-distal ICA. While the S curve may not be specific, its presence in individuals <70 years old should alert the clinician to the possibility that FMD is present. (Source: Vascular Medicine recent issues)
Source: Vascular Medicine recent issues - October 10, 2014 Category: Internal Medicine Authors: Sethi, S. S., Lau, J. F., Godbold, J., Gustavson, S., Olin, J. W. Tags: Original Articles Source Type: research
