Retraction Note to: MicroRNA-495 mimics delivery inhibits lung tumor progression
(Source: Tumor Biology)
Source: Tumor Biology - November 1, 2016 Category: Cancer & Oncology Source Type: research
Transcriptome analysis of distinct long non-coding RNA transcriptional fingerprints in lung adenocarcinoma and squamous cell carcinoma
In this study, we tried to develop and validate novel long non-coding RNA (lncRNA)-based signatures to facilitate the diagnosis and individualized treatment of LUAD and LUSC. To analyze the distinct lncRNA profiling in LUAD and LUSC, the paired tissue samples of RNA sequencing or microarray data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) was used. We found that lncRNA expression pattern is different in LUAD and LUSC, and three up-regulated and down-regulated lncRNAs expressions in LUAD and LUSC tissues were validated. In addition, knockdown of the up-regulated lncRNA AFAP1-AS1 and LINC00511 impai...
Source: Tumor Biology - October 28, 2016 Category: Cancer & Oncology Source Type: research
Tissue transglutaminase 2 exerts a tumor-promoting role in hepatitis B virus-related hepatocellular carcinoma
In this study, we aimed to explore the expression and function of TG2 on HBV-related HCC progression. The expression levels of TG2 were examined in a series of HBV-related HCC tissues and a panel of HCC cell lines. The effects of TG2 knockdown on the proliferation and migration of HBV-related cells were determined. TG2 expression was found to be significantly upregulated in HBV-related HCC tissues. TG2 expression was higher in HBV-related HCC cell lines than HBV-unrelated HCC cell lines. Moreover, inhibition of TG2 in HCC cell lines HepG2.2.15 and Hep3B could inhibit cell proliferation, migration, and invasion in vitro. Ou...
Source: Tumor Biology - October 24, 2016 Category: Cancer & Oncology Source Type: research
The long non-coding RNA maternally expressed gene 3 activates p53 and is downregulated in esophageal squamous cell cancer
In this study, we used quantitative real-time polymerase chain reaction (qRT-PCR) to investigate expression of lncRNA, maternally expressed gene 3 (MEG3) in ESCC. Ectopic expression of MEG3 was performed in ESCC cell lines. Proliferation and apoptosis of ESCC cell lines were analyzed after ectopic expression of MEG3. We found MEG3 was significantly downregulated in ESCC tissues compared with normal tissues by qRT-PCR. Low expression of MEG3 was correlated with lymph node metastasis and advanced TNM stages of ESCC patients and indicated shorter survival (HR = 0.471, 95 % CI 0.234–0.950,P = 0.035), which was confirme...
Source: Tumor Biology - October 23, 2016 Category: Cancer & Oncology Source Type: research
Erratum to: miR-143 inhibits tumor progression by targeting FAM83F in esophageal squamous cell carcinoma
(Source: Tumor Biology)
Source: Tumor Biology - October 23, 2016 Category: Cancer & Oncology Source Type: research
Chloroquine inhibits tumor growth and angiogenesis in malignant pleural effusion
AbstractMalignant pleural effusion (MPE) is associated with a poor prognosis in lung cancer. Currently, no effective cure exists for MPE. Chloroquine (CQ) has been demonstrated to induce vascular normalization and inhibit tumor growth. The aim of this study was to assess whether CQ affects MPE. The xenografts mice were divided into normal saline (NS), CQ, or bevacizumab (BE) group. Tumor growth and microvascular density (MVD) were monitored. We explored the effect of CQ on the proliferation, survival, and proangiogenic signaling of tumor cells in vitro. We further evaluated the effects of CQ on the viability, migration, an...
Source: Tumor Biology - October 21, 2016 Category: Cancer & Oncology Source Type: research
Up-regulation of small nucleolar RNA 78 is correlated with aggressive phenotype and poor prognosis of hepatocellular carcinoma
In conclusion, SNORD78 may be associated with aggressive phenotype and poor prognosis of HCC. (Source: Tumor Biology)
Source: Tumor Biology - October 20, 2016 Category: Cancer & Oncology Source Type: research
Demethoxycurcumin was superior to temozolomide in the inhibition of the growth of glioblastoma stem cells in vivo
AbstractTemozolomide (TMZ) is widely used in the treatment of glioblastoma multiforme (GBM) as it can effectively inhibit the growth of GBM for some months; however, this cancer type is still incurable. The existence of glioma stem cells (GSCs) is thought to be responsible for the invariable recurrence of GBM after treatment, but GSCs are insensitive to TMZ. Our recent research showed that demethoxycurcumin (DMC), a component of curcumin, was superior to TMZ in its ability to inhibit proliferation and induce apoptosis of GSCs in vitro. In addition, the combined treatment of TMZ + DMC induced more obvious anti-GSC effects. ...
Source: Tumor Biology - October 17, 2016 Category: Cancer & Oncology Source Type: research
The role of microRNA-196a in tumorigenesis, tumor progression, and prognosis
AbstractMicroRNAs are a large group of non-coding RNAs that have emerged as regulators of various biological processes, especially carcinogenesis and cancer progression. Recent evidence has shown that microRNA-196a (miR-196a) is upregulated in most types of tumors and involved in multiple biological processes via translational inhibition and mRNA cleavage, such as cell proliferation, migration, and invasion, mostly functioning as an oncogene. Dysregulation of miR-196a promotes oncogenesis and tumor progression. In this review, we summarize the upstream regulators, target genes, signaling pathways, and single nucleotide pol...
Source: Tumor Biology - October 17, 2016 Category: Cancer & Oncology Source Type: research
Overexpression of cannabinoid receptor 1 promotes renal cell carcinoma progression
AbstractRenal cell carcinoma (RCC) is a common urologic tumor with a poor prognosis. Cannabinoid receptor 1 (CB1), which is a G protein-coupled receptor, has recently been reported to participate in the genesis and development of various cancers. However, the exact role of CB1 in RCC is unknown. The aim of this study was to determine the role of CB1 in RCC cell lines and RCC prognosis, thus underlying its potential as a therapeutic target. Immunohistochemistry and western blots were performed to investigate the expression of CB1 in RCC tissues and to determine its clinicopathological significance in RCC patients. Additiona...
Source: Tumor Biology - October 17, 2016 Category: Cancer & Oncology Source Type: research
Hedgehog/Gli1 signal pathway facilitates proliferation, invasion, and migration of cutaneous SCC through regulating VEGF
AbstractSince hedgehog (HH)/Gli1 that contributes to cancer proliferation and metastasis has been masked for decades, the signaling pathway was investigated about its exact role in proliferation and metastasis of cutaneous squamous cell carcinoma (SCC). Sonic hedgehog homolog (Shh), GLI family zinc finger 1 (Gli1), and vascular endothelial growth factor (VEGF) expressions in cutaneous SCC tissues were analyzed with immunohistochemistry, and their correlations with cutaneous SCC patients ’ prognosis were conducted with Kaplan-Meier curve. Regarding in vitro studies, effects of the HH signaling pathway, and cyclopamine on ...
Source: Tumor Biology - October 16, 2016 Category: Cancer & Oncology Source Type: research
PI3K and MAPK pathways mediate the BDNF/TrkB-increased metastasis in neuroblastoma
In this study, we investigated the role of BDNF/TrkB on metastasis in NB. A tetracycline-regulated TrkB-expressing NB cell line (TB3) was used. Scratch wound healing assay, Boyden chamber migration, and invasion assays were performed to study the migration and invasion of TB3 cells. A tumor xenograft model using SCID-Beige mice was utilized to detect the metastasis of NB tumors in vivo. Inhibitors of PI3K, MAPK, Akt, and mTOR were used. Western blotting was performed to study the expressions of P-Akt, P-Erk, and P-mTOR. Our results showed that in TrkB-expressing NB cells, BDNF treatment significantly increased gap closing ...
Source: Tumor Biology - October 16, 2016 Category: Cancer & Oncology Source Type: research
TRPV6 is a prognostic marker in early-stage cervical squamous cell carcinoma
AbstractTransient receptor potential vanilloid 6 (TRPV6) has been shown to promote caner proliferation in several solid tumors, leading to unfavorable clinical outcomes. Our study aimed to elucidate the clinical significance of TRPV6 in patients with early-stage cervical squamous cell carcinoma (CSCC). The mRNA expression of TRPV6 was measured in 12 paired early-stage CSCC specimens and six cervical carcinoma cell lines using quantitative real-time PCR (qRT-PCR). Western blotting and immunohistochemistry (IHC) were employed to examine the protein expression level of TRPV6 in four paired specimens, 175 paraffin-embedded ear...
Source: Tumor Biology - October 16, 2016 Category: Cancer & Oncology Source Type: research
Expression profile and prognostic value of SAV1 in patients with pancreatic ductal adenocarcinoma
This study aimed at evaluating the prognostic significance and associated expression of SAV1 in pancreatic ductal adenocarcinoma (PDAC) patients. The expression of SAV1 in tissue specimens of PDAC patients were assayed with immunohistochemistry on a tissue microarray. The correlations between SAV1 expression and clinicopathological characteristics were analyzed by Pearson ’s chi-square test, Fisher’s exact test, and Spearman’s rank. The prognostic factors for overall survival were analyzed by univariate and multivariate Cox regression. The percentage of SAV1 expression in PDAC (50.6 %) was significantly lower than t...
Source: Tumor Biology - October 16, 2016 Category: Cancer & Oncology Source Type: research
Methylation in promoter regions of PITX2 and RASSF1A genes in association with clinicopathological features in breast cancer patients
This study shows different levels of heterogeneous methylation acquired by MS-HRM assay of the promoter region ofRASSF1A andPITX2 and its relationship with clinicopathological features of 149 breast cancer patients. We noticed that immunohistopathological subtypes of breast cancer contain distinct promoter methylation patterns. All these data suggest that hypermethylation of the CpG island promoters ofRASSF1A andPITX2 might play an essential role in the very early stages of breast cancer pathogenesis. (Source: Tumor Biology)
Source: Tumor Biology - October 14, 2016 Category: Cancer & Oncology Source Type: research
