Suppression of CD26 inhibits growth and metastasis of pancreatic cancer
This study aimed to investigate the effect of CD26 on growth and metastasis of pancreatic cancer cells in vitro and in vivo. We found in this study that CD26 expression was higher in cell lines that derived from the metastatic sites than those from the primary tumor sites. In specimens of pancreatic cancer patients, CD26 expression was higher in cancerous tissues than in paired normal tissues. In in vitro experiments, knockdown of CD26 expression inhibited cell growth, migration, invasion, colony formation, and increased cell apoptosis of pancreatic cancer cells. Knockdown of CD26 also decreased tumor growth and liver meta...
Source: Tumor Biology - October 6, 2016 Category: Cancer & Oncology Source Type: research
Rab14 is overexpressed in ovarian cancers and promotes ovarian cancer proliferation through Wnt pathway
In conclusion, the present study demonstrated that Rab14 promotes aggressiveness of ovarian cancer cell through, at l east partly, Wnt signaling pathway. (Source: Tumor Biology)
Source: Tumor Biology - October 6, 2016 Category: Cancer & Oncology Source Type: research
BRCA1 and MDM2 as independent blood-based biomarkers of head and neck cancer
In conclusion, this study suggests that BRCA1 and MDM2 play a crucial role in the pathogenesis of HNC and could be used independently as predictive biomarkers for HNC. (Source: Tumor Biology)
Source: Tumor Biology - October 5, 2016 Category: Cancer & Oncology Source Type: research
The roles of microRNAs related with progression and metastasis in human cancers
AbstractMetastasis is an important factor in predicting the prognosis of the patients with cancers and contributes to high cancer-related mortality. Recent studies indicated that microRNAs (miRNAs) played a functional role in the initiation and progression of human malignancies. MicroRNAs are small non-coding RNAs of about 22 nucleotides in length that can induce messenger RNA (mRNA) degradation or repress mRNA translation by binding to the 3 ′ untranslated region (3′-UTR) of their target genes. Overwhelming reports indicated that miRNAs could regulate cancer invasion and metastasis via epithelial-to-mesenchymal transi...
Source: Tumor Biology - October 5, 2016 Category: Cancer & Oncology Source Type: research
Regulation of exosomes released from normal ovarian epithelial cells and ovarian cancer cells
AbstractAs important cell to cell communicator, exosomes carry a range of bioactive molecules which can significantly influence phenotype of recipient cells. Inhibiting or removing cancer cell-derived exosomes are of therapeutic interest. However, regulation of secretion and release mechanism of exosomes is still unclear. To explore the regulation of exosomes released from normal ovarian epithelial cells and ovarian cancer cells, a normal ovarian epithelial cell line and three ovarian epithelial cancer cell lines were utilized to investigate their exosomes ’ release and regulation. A cervical cancer cell SiHa was used fo...
Source: Tumor Biology - October 5, 2016 Category: Cancer & Oncology Source Type: research
miR-203 is a predictive biomarker for colorectal cancer and its expression is associated with BIRC5
In conclusion, miR-203 was down-regulated in CRC tissues and involved in the onset and progression of CRC. The expressions of miR-203 and BIRC5 in CRC were significantly negatively correlated, suggesting that BIRC5 may be regulated by miR-203. miR-203 is a potential suppressor and predictiv e biomarker for CRC. (Source: Tumor Biology)
Source: Tumor Biology - October 5, 2016 Category: Cancer & Oncology Source Type: research
Highly expressed lncRNA CRNDE promotes cell proliferation through Wnt/ β-catenin signaling in renal cell carcinoma
AbstractRecently, numerous studies revealed that long non-coding RNAs (lncRNAs) play complex roles in the field of tumor biology, while the functions of lncRNA in renal cell carcinoma (RCC) remain largely unknown. In the current study, we retrieved Oncomine database and found a lncRNA colorectal neoplasia differentially expressed (CRNDE) which is highly expressed in different cohorts of RCC patients; this clue reminds us that CRNDE might exert its functions in RCC tumorigenesis. We then detected the level of CRNDE in fresh RCC tissues and found that CRNDE is significantly up-regulated compared with adjacent tissues. Furthe...
Source: Tumor Biology - October 5, 2016 Category: Cancer & Oncology Source Type: research
Long noncoding RNA expression profile of infantile hemangioma identified by microarray analysis
This study aimed to assess the expression profiles of lncRNAs in IH and adjacent normal tissue samples, exploring the biological functions of lncRNAs as well as their involvement in IH pathogenesis. The lncRNA expression profiles were determined by lncRNA microarrays. A total of 1259 and 857 lncRNAs were upregulated and downregulated in IH, respectively, at a fold change cutoff of 2.0 (p < 0.05); in addition, 1469 and 1184 messenger RNAs (mRNAs) were upregulated and downregulated, respectively (fold change cutoff of 2.0;p < 0.05). A total of 292 differentially expressed mRNAs were targeted by the lncRNAs with a...
Source: Tumor Biology - October 4, 2016 Category: Cancer & Oncology Source Type: research
Reversal effect of ouabain on multidrug resistance in esophageal carcinoma EC109/CDDP cells by inhibiting the translocation of Wnt/ β-catenin into the nucleus
AbstractThe incidence of esophageal carcinoma is increasing throughout the world. A major obstacle to its treatment is acquired multidrug resistance (MDR) which results in the failure of chemotherapy and patient relapse. Here, we identified that ouabain is capable of reversing MDR to cisplatin (CDDP) in EC109/CDDP cells and explore the possible mechanisms of action. The parental and the MDR cell lines were both sensitive to ouabain with 50 % inhibitory concentration (IC50) values of 258.11 and 710.63 nM, respectively. Cisplatin cytotoxicity increased in the EC109/CDDP cells by the addition of ouabain which helps promot...
Source: Tumor Biology - October 4, 2016 Category: Cancer & Oncology Source Type: research
Cancer/testis antigens as molecular drug targets using network pharmacology
AbstractPresent chemotherapeutic drugs have limited efficacy and severe side effects. Considering the complexity of cancer, an effective strategy is necessary to discover multiple new drug targets. Cancer/testis antigens are vital for cancer cell progression. We have performed a computational network analysis of cancer/testis antigens and assessed these antigens as drug targets. During this analysis, protein interaction network of 700 human CT antigens was investigated. CT antigen network consisted of eight independent components. Four major hubs and two minor hubs were identified that play nodal role in the flow of inform...
Source: Tumor Biology - October 4, 2016 Category: Cancer & Oncology Source Type: research
CD4+ T cell-mediated cytotoxicity eliminates primary tumor cells in metastatic melanoma through high MHC class II expression and can be enhanced by inhibitory receptor blockade
AbstractMetastatic melanoma is a rapidly progressing disease with high mortality rate and limited treatment options. Immunotherapy based on tumor-targeting cytotoxic T cell responses represents a promising strategy. To assist in its development, we examined the possibility and efficacy of using CD4+ cytotoxic T cells. The regulatory mechanisms controlling CD4+ T cell-mediated cytotoxicity were also investigated. We found that naturally occurring granzyme B and perforin-expressing CD4+ cytotoxic T cells can be recovered from metastatic melanoma patients at significantly elevated frequencies compared to those from healthy co...
Source: Tumor Biology - October 4, 2016 Category: Cancer & Oncology Source Type: research
A new ten-gene risk fraction model serving as prognostic indicator for clinical outcome of multiple myeloma
AbstractMultiple myeloma (MM) is a kind of aggressive tumor prevalent with high heterogeneity. Abnormal expression of certain genes may lead to the occurrence and development of MM. Nowadays, it is not commonly seen in clinical research to predict the prognostic circumstances of patients with MM by multiple gene expression profiling method. Identification of potential genes in prognostic process could be beneficial for clinical management of MM. Therefore, we aimed to build a risk fraction model to screen out the prognostic indicator for clinical outcome of MM. Microarray data were downloaded from the Genome Expression Omn...
Source: Tumor Biology - October 4, 2016 Category: Cancer & Oncology Source Type: research
Serum levels of apolipoprotein E correlates with disease progression and poor prognosis in breast cancer
In this study, we explored the potential diagnostic and prognostic role of serum ApoE in breast cancer patients. Subject cohorts consisted of 152 normal healthy controls female and 257 breast cancer cases. Serum levels of ApoE were determined with turbidimetric immunoassay. The serum levels of ApoE were significantly elevated in breast cancer patients compared with normal healthy controls (45.82 ± 13.96 mg/L vs. 33.61 ± 6.44 mg/L, respectively,P < 0.0001) and also significantly associated with TNM stage and lymph nodes status (allP < 0.05). Area under receiver operating characteristic curve for serum A...
Source: Tumor Biology - October 4, 2016 Category: Cancer & Oncology Source Type: research
Transcriptomic characterization of differential gene expression in oral squamous cell carcinoma: a meta-analysis of publicly available microarray data sets
AbstractOral squamous cell carcinoma (OSCC) is a highly prevalent cancer worldwide, and OSCC often goes undiagnosed until advanced disease is present, which contributes to a low survival rate for OSCC patients. The identification of biomarkers for the early detection OSCC and novel therapeutic targets for OSCC treatment is an important research objective. We performed bioinformatics analyses of the gene expression profile of OSCC using microarray data to identify genes that contribute to the development of OSCC. We also predicted the transcription factors involved in the regulation of differential gene expression in OSCC. ...
Source: Tumor Biology - October 3, 2016 Category: Cancer & Oncology Source Type: research
Association of single-nucleotide polymorphisms of high-mobility group box 1 with susceptibility and clinicopathological characteristics of uterine cervical neoplasia in Taiwanese women
In conclusion, Taiwanese women with TC or TC/CC in HMGB1 SNP rs1412125 as well as CG or CG/GG in rs2249825 were su sceptible to the development of cervical invasive cancer. (Source: Tumor Biology)
Source: Tumor Biology - October 3, 2016 Category: Cancer & Oncology Source Type: research
