Methylation in promoter regions of PITX2 and RASSF1A genes in association with clinicopathological features in breast cancer patients

This study shows different levels of heterogeneous methylation acquired by MS-HRM assay of the promoter region ofRASSF1A andPITX2 and its relationship with clinicopathological features of 149 breast cancer patients. We noticed that immunohistopathological subtypes of breast cancer contain distinct promoter methylation patterns. All these data suggest that hypermethylation of the CpG island promoters ofRASSF1A andPITX2 might play an essential role in the very early stages of breast cancer pathogenesis.
Source: Tumor Biology - Category: Cancer & Oncology Source Type: research