Therapeutic Advances in Gastroenterology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The role of naloxegol in the management of opioid-induced bowel dysfunction
Opioid-induced constipation (OIC) and other gastrointestinal (GI) symptoms of opioid-induced bowel dysfunction (OIBD) significantly deteriorate patients’ quality of life and may lead to noncompliance with opioid schedule and undertreatment of pain. Although traditional oral laxatives are the first-line treatment of OIC, they do not address OIBD pathophysiology, and display numerous adverse effects. OIC treatment includes prokinetics (lubiprostone), opioid switch, and changing route of opioid administration. Targeted management of OIBD comprises the use of purely peripherally acting μ-opioid receptor antagonists (P...
Source: Therapeutic Advances in Gastroenterology - August 7, 2016 Category: Gastroenterology Authors: Leppert, W., Woron, J. Tags: Reviews Source Type: research

Experience with biosimilar infliximab (CT-P13) in paediatric patients with inflammatory bowel diseases
Infliximab was the first monoclonal antibody used in the treatment of inflammatory bowel disease (IBD). Over several years, this antitumour necrosis factor (TNF) treatment proved its efficacy in both induction and maintenance therapy. In many cases this biological treatment stopped the progression of the disease, probably also decreasing morbidity and hospitalization rates, and improving patients’ comfort. When the patent on infliximab started to expire, the first biosimilar of a monoclonal antibody was introduced onto the pharmacological market. Biosimilar infliximab was studied in rheumatology and proved a high sim...
Source: Therapeutic Advances in Gastroenterology - August 7, 2016 Category: Gastroenterology Authors: Sieczkowska, J., Jarzebicka, D., Meglicka, M., Oracz, G., Kierkus, J. Tags: Reviews Source Type: research

Placement of a 6 mm, fully covered metal stent for main pancreatic head duct stricture due to chronic pancreatitis: a pilot study (with video)
Conclusion: In conclusion, this novel FCSEMS is acceptable for stent placement in cases of chronic pancreatitis with a main pancreatic duct stricture. (Source: Therapeutic Advances in Gastroenterology)
Source: Therapeutic Advances in Gastroenterology - August 7, 2016 Category: Gastroenterology Authors: Ogura, T., Onda, S., Takagi, W., Kitano, M., Sano, T., Okuda, A., Miyano, A., Masuda, D., Takeuchi, T., Fukunishi, S., Higuchi, K. Tags: Original Research Source Type: research

Closure of gastrointestinal defects with Ovesco clip: long-term results and clinical implications
Conclusion: OTSC deployment is an effective and minimally-invasive procedure for GI defects in acute settings. It avoids emergency surgical repair and it allows, in most cases, completion of the primary endoscopic procedure. OTSC should be incorporated as an essential technique of today’s modern endoscopic armamentarium in the management of GI defects in acute settings. OTSCs were less effective in cases of chronic defects. (Source: Therapeutic Advances in Gastroenterology)
Source: Therapeutic Advances in Gastroenterology - August 7, 2016 Category: Gastroenterology Authors: Donatelli, G., Cereatti, F., Dhumane, P., Vergeau, B. M., Tuszynski, T., Marie, C., Dumont, J.-L., Meduri, B. Tags: Original Research Source Type: research

An observational study of extending FOLFOX chemotherapy, lengthening the interval between radiotherapy and surgery, and enhancing pathological complete response rates in rectal cancer patients following preoperative chemoradiotherapy
Conclusion: The intensified multimodality therapy was well tolerated in our cohort and resulted in a considerably high pathologic complete response rate. Regardless of favorable short-term clinical outcomes, long-term oncologic outcomes will be closely monitored among the patients with a pathologic complete response. (Source: Therapeutic Advances in Gastroenterology)
Source: Therapeutic Advances in Gastroenterology - August 7, 2016 Category: Gastroenterology Authors: Huang, C.-M., Huang, M.-Y., Tsai, H.-L., Huang, C.-W., Ma, C.-J., Yeh, Y.-S., Juo, S.-H., Huang, C.-J., Wang, J.-Y. Tags: Original Research Source Type: research

Association of noninvasive quantitative decline in liver fat content on MRI with histologic response in nonalcoholic steatohepatitis
Conclusions: Utilizing paired MRI-PDFF and liver histology data, we demonstrate that a relative reduction of 29% in liver fat on MRI-PDFF is associated with a histologic response in NASH. After external validation by independent research groups, these results can be incorporated into designing future NASH clinical trials, especially those utilizing change in hepatic fat quantified by MRI-PDFF, as a treatment endpoint. (Source: Therapeutic Advances in Gastroenterology)
Source: Therapeutic Advances in Gastroenterology - August 7, 2016 Category: Gastroenterology Authors: Patel, J., Bettencourt, R., Cui, J., Salotti, J., Hooker, J., Bhatt, A., Hernandez, C., Nguyen, P., Aryafar, H., Valasek, M., Haufe, W., Hooker, C., Richards, L., Sirlin, C. B., Loomba, R. Tags: Original Research Source Type: research

The role of antioxidants and zinc in minimal hepatic encephalopathy: a randomized trial
Conclusion: Antioxidant and zinc supplementation can improve MHE in patients with liver cirrhosis. (Source: Therapeutic Advances in Gastroenterology)
Source: Therapeutic Advances in Gastroenterology - August 7, 2016 Category: Gastroenterology Authors: Mousa, N., Abdel-Razik, A., Zaher, A., Hamed, M., Shiha, G., Effat, N., Elbaz, S., Elhelaly, R., Hafez, M., El-Wakeel, N., Eldars, W. Tags: Original Research Source Type: research

Clinical impact of dual red imaging in colorectal endoscopic submucosal dissection: a pilot study
Conclusions: DRI improves the visibility of vessels, especially that of arteries, as they appear orange, and the demarcation line of the muscle layer. DRI may help to make colorectal ESD safer and faster. (Source: Therapeutic Advances in Gastroenterology)
Source: Therapeutic Advances in Gastroenterology - August 7, 2016 Category: Gastroenterology Authors: Ninomiya, Y., Oka, S., Tanaka, S., Hirano, D., Sumimoto, K., Tamaru, Y., Asayama, N., Shigita, K., Nishiyama, S., Hayashi, N., Chayama, K. Tags: Original Research Source Type: research

Use of proton-pump inhibitors among adults: a Danish nationwide drug utilization study
Conclusions: The use of PPIs is extensive and increasing rapidly, especially among the elderly. (Source: Therapeutic Advances in Gastroenterology)
Source: Therapeutic Advances in Gastroenterology - August 7, 2016 Category: Gastroenterology Authors: Pottegard, A., Broe, A., Hallas, J., de Muckadell, O. B. S., Lassen, A. T., Lodrup, A. B. Tags: Original Research Source Type: research

Serial monitoring of faecal calprotectin for the assessment of endoscopic recurrence in asymptomatic patients after ileocolonic resection for Crohns disease: a long-term prospective study
Conclusions: Consecutive monitoring of FC is useful for the assessment of endoscopic recurrence after the initial ileocolonoscopy. Increased FC levels indicate a need for repeat ileocolonoscopy, while sustained low FC levels predict a low risk of endoscopic recurrence. In patients maintaining low FC levels, unnecessary invasive endoscopic examinations can be avoided. (Source: Therapeutic Advances in Gastroenterology)
Source: Therapeutic Advances in Gastroenterology - August 7, 2016 Category: Gastroenterology Authors: Yamamoto, T., Shimoyama, T., Umegae, S., Matsumoto, K. Tags: Original Research Source Type: research

Magnetic resonance enterography versus capsule endoscopy activity indices for quantification of small bowel inflammation in Crohns disease
Conclusions: Modest correlation between VCE- and MRE-based quantitative indices of inflammation in patients with quiescent SB CD was observed. Between-modality correlation was higher in patients with endoscopically severe disease. DW-MRE gauged by Clermont score was at least as accurate as contrast-enhanced MRE for quantification of SB inflammation. (Source: Therapeutic Advances in Gastroenterology)
Source: Therapeutic Advances in Gastroenterology - August 7, 2016 Category: Gastroenterology Authors: Kopylov, U., Klang, E., Yablecovitch, D., Lahat, A., Avidan, B., Neuman, S., Levhar, N., Greener, T., Rozendorn, N., Beytelman, A., Yanai, H., Dotan, I., Chowers, Y., Weiss, B., Ben-Horin, S., Amitai, M. M., Eliakim, R., on behalf of the Israeli IBD resea Tags: Original Research Source Type: research

Endoscopic ultrasound-assisted gastrointestinal hemostasis: an evolving technique
Gastrointestinal bleeding can range from grossly visible blood in stool or vomitus to microscopic bleed. However, any kind of bleeding can lead to potential life-threatening consequences. A small proportion of patients with gastrointestinal bleeding remain refractory to initial endoscopic hemostasis. While some are successfully managed by repeat endoscopic intervention, a few fail to respond or are not amenable to endoscopic hemostasis. As of now, the next level of intervention is passed on to either surgeons or interventional radiologists. There is new evidence suggesting the increased utility of endoscopic ultrasound (EU...
Source: Therapeutic Advances in Gastroenterology - June 11, 2016 Category: Gastroenterology Authors: Jain, D., Thosani, N., Singhal, S. Tags: Reviews Source Type: research

Understanding the gastrointestinal manifestations of Fabry disease: promoting prompt diagnosis
Fabry disease is a rare X-linked lysosomal storage disease characterized by the dysfunction of multiple systems, including significant gastrointestinal involvement such as diarrhea, abdominal pain, early satiety and nausea. The gastrointestinal symptoms of Fabry disease are thought to be due to neuropathic and myopathic changes leading to symptoms of dysmotility that are encountered in many other disorders. The gastrointestinal symptoms can often be one of the presenting signs of the disease in childhood, but can be misdiagnosed by gastroenterologists for many years due to their nonspecific presentation. As the chief treat...
Source: Therapeutic Advances in Gastroenterology - June 11, 2016 Category: Gastroenterology Authors: Zar-Kessler, C., Karaa, A., Sims, K. B., Clarke, V., Kuo, B. Tags: Reviews Source Type: research

The intestinal microbiome, barrier function, and immune system in inflammatory bowel disease: a tripartite pathophysiological circuit with implications for new therapeutic directions
We discuss the tripartite pathophysiological circuit of inflammatory bowel disease (IBD), involving the intestinal microbiota, barrier function, and immune system. Dysfunction in each of these physiological components (dysbiosis, leaky gut, and inflammation) contributes in a mutually interdependent manner to IBD onset and exacerbation. Genetic and environmental risk factors lead to disruption of gut homeostasis: genetic risks predominantly affect the immune system, environmental risks predominantly affect the microbiota, and both affect barrier function. Multiple genetic and environmental ‘hits’ are likely nece...
Source: Therapeutic Advances in Gastroenterology - June 11, 2016 Category: Gastroenterology Authors: Vindigni, S. M., Zisman, T. L., Suskind, D. L., Damman, C. J. Tags: Reviews Source Type: research

The interplay between the microbiome and the adaptive immune response in cancer development
The data from different studies suggest a bacterial role in cancer genesis/progression, often modulating the local immune response. This is particularly so at the mucosal level where the bacterial presence is strong and the immune system is highly reactive. The epithelial surfaces of the body, such as the skin and mucosa, are colonized by a vast number of microorganisms, which represent the so-called normal microbiome. Normally the microbiome does not cause a proinflammatory response because the immune system has developed different strategies for the tolerance of commensal bacteria, but when these mechanisms are impaired ...
Source: Therapeutic Advances in Gastroenterology - June 11, 2016 Category: Gastroenterology Authors: Russo, E., Taddei, A., Ringressi, M. N., Ricci, F., Amedei, A. Tags: Reviews Source Type: research