Association of noninvasive quantitative decline in liver fat content on MRI with histologic response in nonalcoholic steatohepatitis

Conclusions:
Utilizing paired MRI-PDFF and liver histology data, we demonstrate that a relative reduction of 29% in liver fat on MRI-PDFF is associated with a histologic response in NASH. After external validation by independent research groups, these results can be incorporated into designing future NASH clinical trials, especially those utilizing change in hepatic fat quantified by MRI-PDFF, as a treatment endpoint.

Source: Therapeutic Advances in Gastroenterology - August 7, 2016 Category: Gastroenterology Authors: Patel, J., Bettencourt, R., Cui, J., Salotti, J., Hooker, J., Bhatt, A., Hernandez, C., Nguyen, P., Aryafar, H., Valasek, M., Haufe, W., Hooker, C., Richards, L., Sirlin, C. B., Loomba, R. Tags: Original Research Source Type: research