Therapeutic Advances in Gastroenterology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Endoscopic closure of persistent gastrocutaneous fistulae, after percutaneous endoscopic gastrostomy (PEG) tube placement, using the over-the-scope-clip system
Conclusions: OTSC application is a safe and effective endoscopic approach for the closure of persistent GC fistulae secondary to a complication of PEG tube placement. (Source: Therapeutic Advances in Gastroenterology)
Source: Therapeutic Advances in Gastroenterology - June 4, 2015 Category: Gastroenterology Authors: Singhal, S., Changela, K., Culliford, A., Duddempudi, S., Krishnaiah, M., Anand, S. Tags: Original Research Source Type: research

Endoscopic management of iatrogenic perforations during endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) for colorectal polyps: a case series
Conclusion: Surgery is no longer the first choice in the management of iatrogenic perforations during EMR and ESD for colorectal polyps; in selected patients with small perforations and minimal extraluminal contamination, conservative management with application of endoscopic clips, antibiotics and close patient monitoring constitute a safe and effective treatment option, avoiding the morbidity of major surgery. (Source: Therapeutic Advances in Gastroenterology)
Source: Therapeutic Advances in Gastroenterology - June 4, 2015 Category: Gastroenterology Authors: Pissas, D., Ypsilantis, E., Papagrigoriadis, S., Hayee, B., Haji, A. Tags: Original Research Source Type: research

Specialized enteral nutrition therapy in Crohn's disease patients on maintenance infliximab therapy: a meta-analysis
Conclusions: The use of specialized enteral nutrition therapy in combination with infliximab appears to be more effective at inducing and maintaining clinical remission among patients with Crohn’s disease than infliximab monotherapy. (Source: Therapeutic Advances in Gastroenterology)
Source: Therapeutic Advances in Gastroenterology - June 4, 2015 Category: Gastroenterology Authors: Nguyen, D. L., Palmer, L. B., Nguyen, E. T., McClave, S. A., Martindale, R. G., Bechtold, M. L. Tags: Original Research Source Type: research

Chronic appendicitis: uncommon cause of chronic abdominal pain
(Source: Therapeutic Advances in Gastroenterology)
Source: Therapeutic Advances in Gastroenterology - April 12, 2015 Category: Gastroenterology Authors: Kothadia, J. P., Katz, S., Ginzburg, L. Tags: Letter to the Editor Source Type: research

From historical perspectives to modern therapy: a review of current and future biological treatments for Crohn's disease
Crohn’s disease (CD) is a debilitating, systemic inflammatory disorder with both gastrointestinal and extraintestinal manifestations. Its existence predates modern medicine, but its precise etiology remains incompletely understood. Most authorities suggest a multifactorial pathogenesis owing to a mixture of genetic disorders, immunologic dysregulation, microbiota disequilibrium and environmental influences. Of these factors, the overactive immunologic response seen in CD appears to be the most promising target of medical therapy. Biological agents comprise a relatively new class of drugs that can induce and maintain ...
Source: Therapeutic Advances in Gastroenterology - April 12, 2015 Category: Gastroenterology Authors: Randall, C. W., Vizuete, J. A., Martinez, N., Alvarez, J. J., Garapati, K. V., Malakouti, M., Taboada, C. M. Tags: Reviews Source Type: research

The clinical potential of ramosetron in the treatment of irritable bowel syndrome with diarrhea (IBS-D)
Irritable bowel syndrome (IBS) is a highly prevalent functional bowel disorder. Serotonin (5-HT) is known to play a physiological and pathophysiological role in the regulation of gastrointestinal function. In experimental studies, 5-HT3 receptor antagonists have been reported to slow colon transit, to blunt gastrocolonic reflex, and to reduce rectal sensitivity. Alosetron and cilansetron, potent and selective 5-HT3 receptor antagonists, have proven efficacy in the treatment of IBS with diarrhea (IBS-D). However, alosetron was voluntarily withdrawn due to postmarketing reports of ischemic colitis and complications of consti...
Source: Therapeutic Advances in Gastroenterology - April 12, 2015 Category: Gastroenterology Authors: Min, Y. W., Rhee, P.-L. Tags: Reviews Source Type: research

Hemostatic powder spray: a new method for managing gastrointestinal bleeding
Gastrointestinal bleeding is a leading cause of morbidity and mortality in the United States. The management of gastrointestinal bleeding is often challenging, depending on its location and severity. To date, widely accepted hemostatic treatment options include injection of epinephrine and tissue adhesives such as cyanoacrylate, ablative therapy with contact modalities such as thermal coagulation with heater probe and bipolar hemostatic forceps, noncontact modalities such as photodynamic therapy and argon plasma coagulation, and mechanical hemostasis with band ligation, endoscopic hemoclips, and over-the-scope clips. These...
Source: Therapeutic Advances in Gastroenterology - April 12, 2015 Category: Gastroenterology Authors: Changela, K., Papafragkakis, H., Ofori, E., Ona, M. A., Krishnaiah, M., Duddempudi, S., Anand, S. Tags: Reviews Source Type: research

Cannulation of the biliary tree under endoscopic control with an echoendoscope, without fluoroscopy: report of a case series
Conclusion: Operative EUS without fluoroscopy appears to be a feasible technique. Its major advantages could be to shorten the examination time and to enable biliary or pancreatic operative endoscopy in patients in whom fluoroscopy could be dangerous, such as pregnant women. The endoscopist should have a good training both in EUS and endoscopic retrograde cholangiopancreatography. Prospective, larger studies are needed to confirm our preliminary data. (Source: Therapeutic Advances in Gastroenterology)
Source: Therapeutic Advances in Gastroenterology - April 12, 2015 Category: Gastroenterology Authors: Arcidiacono, P. G., Mangiavillano, B., Carrara, S., Petrone, M. C., Santoro, T., Testoni, P. A. Tags: Original Research Source Type: research

Early 'shallow' needle-knife papillotomy and guidewire cannulation: an effective and safe approach to difficult papilla
Conclusion: In case of difficult papilla, eSNKP followed by guidewire cannulation increases the successful deep biliary cannulation with low rate of complications. (Source: Therapeutic Advances in Gastroenterology)
Source: Therapeutic Advances in Gastroenterology - April 12, 2015 Category: Gastroenterology Authors: Fiocca, F., Fanello, G., Cereatti, F., Maselli, R., Ceci, V., Donatelli, G. Tags: Original Research Source Type: research

The continuing dilemma of chronic appendicitis
(Source: Therapeutic Advances in Gastroenterology)
Source: Therapeutic Advances in Gastroenterology - April 12, 2015 Category: Gastroenterology Authors: Whorwell, P. J. Tags: Editorial Source Type: research

Hypersensitivity reaction to omeprazole in a patient treated for Helicobacter pylori
(Source: Therapeutic Advances in Gastroenterology)
Source: Therapeutic Advances in Gastroenterology - February 2, 2015 Category: Gastroenterology Authors: Anderson, S., Christensen, S. Tags: Letter to the Editor Source Type: research

Treatment and management of ascites and hepatorenal syndrome: an update
Ascites and renal dysfunction are frequent complications experienced by patients with cirrhosis of the liver. Ascites is the pathologic accumulation of fluid in the peritoneal cavity, and is one of the cardinal signs of portal hypertension. The diagnostic evaluation of ascites involves assessment of its granulocyte count and protein concentration to exclude complications such as infection or malignoma and to allow risk stratification for the development of spontaneous peritonitis. Although sodium restriction and diuretics remain the cornerstone of the management of ascites, many patients require additional therapy when the...
Source: Therapeutic Advances in Gastroenterology - February 2, 2015 Category: Gastroenterology Authors: Lenz, K., Buder, R., Kapun, L., Voglmayr, M. Tags: Reviews Source Type: research

Current, new and future biological agents on the horizon for the treatment of inflammatory bowel diseases
Biological agents for inflammatory bowel diseases (IBD) targeting tumor necrosis factor (TNF) have changed the way to treat IBD refractory to standard medications and allowed us to reach new therapeutic goals such as mucosal healing and deep remission. A better understanding of the components of the pathological processes that are a hallmark of IBD has led to the development of a new family of biological agents in Crohn’s disease and ulcerative colitis. Biosimilars, which are copy versions of currently licensed biological agents, will be soon available. The biosimilar of infliximab is as effective and as safe as its ...
Source: Therapeutic Advances in Gastroenterology - February 2, 2015 Category: Gastroenterology Authors: Amiot, A., Peyrin-Biroulet, L. Tags: Reviews Source Type: research

Triple modality testing by endoscopic retrograde cholangiopancreatography for the diagnosis of cholangiocarcinoma
Conclusions: A triple modality approach results in a marked increase in sensitivity for the diagnosis of cholangiocarcinoma compared with single modality testing such as brush cytology and should be considered in the evaluation of indeterminate or suspicious biliary strictures. (Source: Therapeutic Advances in Gastroenterology)
Source: Therapeutic Advances in Gastroenterology - February 2, 2015 Category: Gastroenterology Authors: Nanda, A., Brown, J. M., Berger, S. H., Lewis, M. M., Barr Fritcher, E. G., Gores, G. J., Keilin, S. A., Woods, K. E., Cai, Q., Willingham, F. F. Tags: Original Research Source Type: research

New insights and challenges in microscopic colitis
Microscopic colitis (MC) is described as an inflammatory bowel disease characterized by chronic, bloodless diarrhea with normal or close to normal endoscopic findings. Histopathological examination reveals two subtypes: collagenous colitis (CC) and lymphocytic colitis (LC), which are indistinguishable clinically. The disease debuts typically in middle-aged patients, but can occur at all ages, including children. A female predominance is found in both CC and LC, but is not confirmed by others in LC. The etiology is unclear, but the disease has been assumed to be of autoimmune origin. However, several etiologies may render a...
Source: Therapeutic Advances in Gastroenterology - December 11, 2014 Category: Gastroenterology Authors: Ohlsson, B. Tags: Reviews Source Type: research