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Prognostic significance of adverse events in patients with hepatocellular carcinoma treated with sorafenib
Sorafenib is the standard treatment for patients with hepatocellular carcinoma (HCC) with advanced stage disease. Although its effectiveness has been demonstrated by randomized clinical trials and confirmed by field practice studies, reliable markers predicting therapeutic response have not yet been identified. Like other tyrosine kinase inhibitors, treatment with sorafenib is burdened by the development of adverse effects, the most frequent being cutaneous toxicity, diarrhoea, arterial hypertension and fatigue. In recent years, several studies have analysed the correlation between off-target effects and sorafenib efficacy...
Source: Therapeutic Advances in Gastroenterology - February 8, 2016 Category: Gastroenterology Authors: Granito, A., Marinelli, S., Negrini, G., Menetti, S., Benevento, F., Bolondi, L. Tags: Reviews Source Type: research

Fecal microbiota transplantation: in perspective
There has been increasing interest in understanding the role of the human gut microbiome to elucidate the therapeutic potential of its manipulation. Fecal microbiota transplantation (FMT) is the administration of a solution of fecal matter from a donor into the intestinal tract of a recipient in order to directly change the recipient’s gut microbial composition and confer a health benefit. FMT has been used to successfully treat recurrent Clostridium difficile infection. There are preliminary indications to suggest that it may also carry therapeutic potential for other conditions such as inflammatory bowel disease, o...
Source: Therapeutic Advances in Gastroenterology - February 8, 2016 Category: Gastroenterology Authors: Gupta, S., Allen-Vercoe, E., Petrof, E. O. Tags: Reviews Source Type: research

Diverticulosis today: unfashionable and still under-researched
Diverticulosis of the colon is a widespread disease, and its prevalence is increasing especially in the developing world. The underlying pathological mechanisms that cause the formation of colonic diverticula remain unclear but are likely to be the result of complex interactions among age, diet, genetic factors, colonic motility, and changes in colonic structure. The large majority of patients remain asymptomatic throughout their life, one fifth of them become symptomatic (developing the so-called ‘diverticular disease’) while only a minority of these will develop acute diverticulitis. The factors predicting th...
Source: Therapeutic Advances in Gastroenterology - February 8, 2016 Category: Gastroenterology Authors: Tursi, A. Tags: Reviews Source Type: research

Overlapping irritable bowel syndrome and inflammatory bowel disease: less to this than meets the eye?
Though distinct in terms of pathology, natural history and therapeutic approach, irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) have some features in common. These include shared symptomatology and largely similar demographics. However, in most instances, clinical presentation, together with laboratory, imaging and endoscopic findings will readily permit the differentiation of active IBD from IBS. More problematic is the situation where a subject with IBD, in apparent remission, continues to complain of symptoms which, in aggregate, satisfy commonly employed criteria for the diagnosis of IBS. Access to...
Source: Therapeutic Advances in Gastroenterology - February 8, 2016 Category: Gastroenterology Authors: Quigley, E. M. M. Tags: Reviews Source Type: research

Air cholangiography in endoscopic bilateral stent-in-stent placement of metallic stents for malignant hilar biliary obstruction
Conclusions: Air cholangiography-assisted stenting can be a safe and effective method for endoscopic bilateral SIS placement of SEMS in patients with malignant hilar biliary obstruction. (Source: Therapeutic Advances in Gastroenterology)
Source: Therapeutic Advances in Gastroenterology - February 8, 2016 Category: Gastroenterology Authors: Lee, J. M., Lee, S. H., Jang, D. K., Chung, K. H., Park, J. M., Paik, W. H., Lee, J. K., Ryu, J. K., Kim, Y.-T. Tags: Original Research Source Type: research

Fully covered self-expandable metal stent in the treatment of postsurgical colorectal diseases: outcome in 29 patients
Conclusion: FCSEMS are considered a possible therapeutic option for treatment of postsurgical strictures and leaks. However, their efficacy in guaranteeing long-term anastomotic patency and leak closure is moderate. A major complication is migration. The use of FCSEMS for colonic postsurgical pathologies should be carefully evaluated for each patient. (Source: Therapeutic Advances in Gastroenterology)
Source: Therapeutic Advances in Gastroenterology - February 8, 2016 Category: Gastroenterology Authors: Cereatti, F., Fiocca, F., Dumont, J.-L., Ceci, V., Vergeau, B.-M., Tuszynski, T., Meduri, B., Donatelli, G. Tags: Original Research Source Type: research

The safety and efficacy of single balloon enteroscopy in the elderly
Conclusion: SBE is safe in elderly patients and delivers higher diagnostic and therapeutic yields compared to younger patients. The elderly are more likely to have angioectasias and undergo APC and electrocoagulation. (Source: Therapeutic Advances in Gastroenterology)
Source: Therapeutic Advances in Gastroenterology - February 8, 2016 Category: Gastroenterology Authors: Davis-Yadley, A. H., Lipka, S., Rodriguez, A. C., Nelson, K. K., Doraiswamy, V., Rabbanifard, R., Kumar, A., Brady, P. G. Tags: Original Research Source Type: research

A novel schedule of erlotinib/capecitabine (7/7) as salvage therapy in previously treated advanced pancreatic adenocarcinoma: a case series
Conclusions: Our result suggests that the combination of a fixed low dose of CAP-ERL 7/7 schedule was tolerated with manageable toxicity and showed encouraging activity as salvage treatment in patients with refractory APC with ECOG performance status 0–2. Further prospective studies are warranted to evaluate this combination. (Source: Therapeutic Advances in Gastroenterology)
Source: Therapeutic Advances in Gastroenterology - February 8, 2016 Category: Gastroenterology Authors: Chen, J., Kaley, K., Garcon, M. C., Rodriguez, T., Saif, M. W. Tags: Original Research Source Type: research

Cardiovascular risk assessment in the treatment of nonalcoholic steatohepatitis: a secondary analysis of the MOZART trial
Conclusions: Ezetimibe improved FRS whereas placebo did not. FRS and CAC scores improved in a greater proportion of patients with ezetimibe; this trend did not reach significance. These findings indicate the utility and feasibility of monitoring cardiovascular risk in a NASH trial. The utility of CAC scores may be higher in trials of longer duration (>=52 weeks) and with older patients (age >=45). ClinicalTrials.gov registration: NCT01766713. (Source: Therapeutic Advances in Gastroenterology)
Source: Therapeutic Advances in Gastroenterology - February 8, 2016 Category: Gastroenterology Authors: Lin, S. C., Ang, B., Hernandez, C., Bettencourt, R., Jain, R., Salotti, J., Richards, L., Kono, Y., Bhatt, A., Aryafar, H., Lin, G. Y., Valasek, M. A., Sirlin, C. B., Brouha, S., Loomba, R. Tags: Original Research Source Type: research

Recent advances in pancreatic cancer: updates and insights from the 2015 annual meeting of the American Society of Clinical Oncology
(Source: Therapeutic Advances in Gastroenterology)
Source: Therapeutic Advances in Gastroenterology - February 8, 2016 Category: Gastroenterology Authors: Abrams, M. J., Rakszawski, K., Vasekar, M., Passero, F., Abbas, A., Jia, Y., Saif, M. W. Tags: Editorials Source Type: research

EUS-guided transmural gallbladder drainage: a new era has begun
(Source: Therapeutic Advances in Gastroenterology)
Source: Therapeutic Advances in Gastroenterology - February 8, 2016 Category: Gastroenterology Authors: Xu, M.-M., Kahaleh, M. Tags: Editorials Source Type: research

Successful use of volumetric laser endomicroscopy in imaging a rectal polyp
(Source: Therapeutic Advances in Gastroenterology)
Source: Therapeutic Advances in Gastroenterology - December 23, 2015 Category: Gastroenterology Authors: Trindade, A. J., Sultan, K., Vamadevan, A. S., Fan, C., Sejpal, D. V. Tags: Letters to the Editor Source Type: research

Acquired factor VII deficiency following FOLFOX in a patient with colorectal cancer who was also DPD deficient
(Source: Therapeutic Advances in Gastroenterology)
Source: Therapeutic Advances in Gastroenterology - December 23, 2015 Category: Gastroenterology Authors: Saif, M. W., Wasif, K., Butler-Bowen, H., Miller, K., Diasio, R. B. Tags: Letters to the Editor Source Type: research

Association between caffeine consumption and nonalcoholic fatty liver disease: a systemic review and meta-analysis
Conclusion: Although total caffeine intake is not associated with the prevalence or hepatic fibrosis of NAFLD, regular coffee caffeine consumption may significantly reduce hepatic fibrosis in patients with NAFLD. (Source: Therapeutic Advances in Gastroenterology)
Source: Therapeutic Advances in Gastroenterology - December 23, 2015 Category: Gastroenterology Authors: Shen, H., Rodriguez, A. C., Shiani, A., Lipka, S., Shahzad, G., Kumar, A., Mustacchia, P. Tags: Reviews Source Type: research

Nausea: a review of pathophysiology and therapeutics
The sensation of nausea is a common occurrence with diverse causes and a significant disease burden. Nausea is considered to function as a protective mechanism, warning the organism to avoid potential toxic ingestion. Less adaptive circumstances are also associated with nausea, including post-operative nausea, chemotherapy-induced nausea, and motion sickness. A common definition of nausea identifies the symptom as a precursor to the act of vomiting. The interaction, though present, does not appear to be a simple relationship. Nausea is unfortunately the ‘neglected symptom’, with current accepted therapy general...
Source: Therapeutic Advances in Gastroenterology - December 23, 2015 Category: Gastroenterology Authors: Singh, P., Yoon, S. S., Kuo, B. Tags: Reviews Source Type: research