Theoretical Biology and Medical Modelling 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Boolean network-based model of the Bcl-2 family mediated MOMP regulation
Conclusions:
In spite of relative simplicity, the Boolean network-based model provides useful insight into main functioning logic of the Bcl-2 switch, consistent with experimental findings. (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - June 14, 2013 Category: Biomedical Science Authors: Tomas TokarZdenko TurcanJozef Ulicny Source Type: research
An integrated multidisciplinary model describing initiation of cancer and the Warburg hypothesis
Conclusions:
A quantitative model is presented that attributes the well-known Warburg effect to a biophysical mechanism driven by a convective disturbance in the cell. Contrary to current understanding, this effect may precipitate cancer development, rather than follow from it, providing new insights into carcinogenesis, cancer treatment, and prevention. (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - June 10, 2013 Category: Biomedical Science Authors: Edward RietmanDouglas FriesenPhilip HahnfeldtRobert GatenbyLynn HlatkyJack Tuszynski Source Type: research
Tumor necrosis factor receptor superfamily 10B (TNFRSF10B): an insight from structure modeling to virtual screening for designing drug against head and neck cancer
Conclusion:
Current research may provide a backbone for understanding structural and functional insights of TNFRSF10B protein. The designed novel inhibitors and predicted interactions might serve to inhibit the disease. Effective in-vitro potent ligands are required which will be helpful in future to design a drug to against Head and neck cancer disease. There is an urgent need for affective drug designing of head and neck cancer and computational tools for examining candidate genes more efficiently and accurately are required. (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - June 1, 2013 Category: Biomedical Science Authors: Rana TahirSheikh SehgalNaureen KhattakJabar Khan KhattakAsif Mir Source Type: research
Modelling gene expression profiles related to prostate tumor progression using binary states
Conclusions:
Results suggest that our methodology may be a valuable tool to study tumor malignancy progression, which might reveal novel cancer therapies. (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - May 31, 2013 Category: Biomedical Science Authors: Emmanuel MartinezVictor Trevino Source Type: research
The design of a new truncated and engineered alpha1-antitrypsin based on theoretical studies: an antiprotease therapeutics for pulmonary diseases
Alpha 1- antitrypsin (alpha1AT) a 54 kDa glycoprotein is a protease inhibitor. In the absence of alpha1AT, elastase released by lung macrophages, was not inhibited and lead to elastin breakdown and pulmonary problems such as emphysema or COPD. alpha1AT has three site of N-glycosylation and a characteristic reactive central loop (RCL). As small-scale medicines are preferred for pulmonary drug delivery, in this study alpha1ATs (1, 2, 3, 4 and 5) were engineered and shortened from the N-terminal region. In order to investigate the effect of different mutations and the deletion of 46 amino acids theoretical studies were perfor...
Source: Theoretical Biology and Medical Modelling - May 24, 2013 Category: Biomedical Science Authors: Nazanin PiroozniaSadegh HasanniaSeyed Shahriar ArabAbbas Sahebghadam LotfiMostafa GhaneiAbbas Shali Source Type: research
Exploring haemodynamics of haemodialysis using extrema points analysis model
Conclusion:
Haemodialysis patients potentially exhibit an aberrant haemodynamic behaviour characterised by higher extrema frequencies of mean arterial blood pressure and lower extrema frequencies of total peripheral resistance. This, in theory, could lead to higher variation in organ perfusion and may be detrimental to vulnerable vascular beds. (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - May 16, 2013 Category: Biomedical Science Authors: Mohamed EldehniAghogho OduduChristopher McIntyre Source Type: research
Using allometric procedures to substantiate the plastochrone method for eelgrass leaf growth assessments
Estimation of leaf productivity in eelgrass (Zostera marina L.) is crucial for evaluating the ecological role of this important seagrass species. Although leaf marking techniques are widely used to obtain estimates of leaf productivity, the accuracy of these assessments, has been questioned mainly because these fail to account for leaf growth bellow the reference mark and also because they apparently disregard the contribution of mature leaf tissues to the growth rate of leaves. On the other hand, the plastochrone method is a simpler technique that has been considered to effectively capture growth in a more realistic way, ...
Source: Theoretical Biology and Medical Modelling - May 16, 2013 Category: Biomedical Science Authors: Héctor Echavarría-HerasElena Solana-ArellanoCecilia Leal-RamírezOscar Castillo Source Type: research
Numerical investigation of the effect of cannula placement on thrombosis
Despite the rapid advancement of left ventricular assist devices (LVADs), adverse events leading to deaths have been frequently reported in patients implanted with LVADs, including bleeding, infection, thromboembolism, neurological dysfunction and hemolysis.Cannulation forms an important component with regards to thrombus formation in assisted patients by varying the intraventricular flow distribution in the left ventricle (LV). To investigate the correlation between LVAD cannula placement and potential for thrombus formation, detailed analysis of the intraventricular flow field was carried out in the present study using a...
Source: Theoretical Biology and Medical Modelling - May 16, 2013 Category: Biomedical Science Authors: ChiWei OngSocrates DokosBeeTing ChanEinly LimAmr Al AbedNoor OsmanSuhaini KadimanNigel Lovell Source Type: research
Computational simulation of the bone remodeling using the finite element method: an elastic-damage theory for small displacements
Conclusion:
The results are consistent with the existing literature which shows that the bone stiffness drops in damaged bone structure under mechanical loading. (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - May 13, 2013 Category: Biomedical Science Authors: Ahmed IdhammadAbdelmounaïm AbdaliNoureddine Alaa Source Type: research
A new method to estimate parameters of the growth model for metastatic tumours
Conclusion:
Analysis of the regression of tumour growth rate with the logarithm of tumour volume can be used to estimate parameters of the tumour growth model and metastasis formation rates, and therefore the number and size distribution of metastases in individuals. (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - May 9, 2013 Category: Biomedical Science Authors: Esmaeil MehraraEva Forssell-AronssonViktor JohansonLars KölbyRagnar HultbornPeter Bernhardt Source Type: research
How to interpret the transmissibility of novel influenza A(H7N9): an analysis of
initial epidemiological data of human cases from China
Conclusions:
It is unlikely to observe an immediate pandemic of novel influenza A(H7N9) virus
with human to human transmission. Continued monitoring of cases and animals would
be the key to elucidate additional epidemiological characteristics of the
virus. (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - May 4, 2013 Category: Biomedical Science Authors: Hiroshi NishiuraKenji MizumotoKeisuke Ejima Source Type: research
How to interpret the transmissibility of novel influenza A(H7N9): an analysis of initial epidemiological data of human cases from China
Conclusions:
It is unlikely to observe an immediate pandemic of novel influenza A(H7N9) virus with human to human transmission. Continued monitoring of cases and animals would be the key to elucidate additional epidemiological characteristics of the virus. (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - May 4, 2013 Category: Biomedical Science Authors: Hiroshi NishiuraKenji MizumotoKeisuke Ejima Source Type: research
Development of a three-dimensional model of the human respiratory system for dosimetric use
Conclusions:
The model can be used for studies of sensitive populations and the homeland security community, in cases where inhalation studies on humans cannot be conducted with toxic contaminants of interest. (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - May 1, 2013 Category: Biomedical Science Authors: Jacky Rosati RoweRay BurtonGeorge McGregorRob McCauleyWei TangRichard Spencer Source Type: research
Determination of the optimal tubulin isotype target as a method for the development of individualized cancer chemotherapy
Conclusions:
Our algorithm, which defines the best profile for each type of cancer (given the drug delivery route and some specified patient characteristics), will help to personalize the design of pharmaceuticals for individual patients. This paper is an attempt to explicitly consider the effects of the tubulin isotype distributions in both cancer and normal cell types, for rational chemotherapy design aimed at optimizing the drug's efficacy with minimal side effects. (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - May 1, 2013 Category: Biomedical Science Authors: Siamak RavanbakhshMelissa GajewskiRussell GreinerJack Tuszynski Source Type: research
Mathematical models for the notch and Wnt signaling pathways and the crosstalk between them during somitogenesis
Conclusions:
Three mathematical models are proposed for the Notch and Wnt pathways and their interaction during somitogenesis. The simulations demonstrate that the extracellular Notch and Wnt signals are essential for the oscillating expressions of both Notch and Wnt target genes. Moreover, the internal negative feedback loops and the three levels of crosstalk between these pathways play important but distinct roles in maintaining the system oscillation. In addition, the results of the parameter sensitivity analysis of the models indicate that the Notch pathway is more sensitive to perturbation in somitogenesis. (Source: T...
Source: Theoretical Biology and Medical Modelling - April 20, 2013 Category: Biomedical Science Authors: Hong-yan WangYan-xin HuangYun-feng QiYu ZhangYong-li BaoLu-guo SunLi-hua ZhengYu-wei ZhangZhi-qiang MaYu-xin Li Source Type: research
