Theoretical Biology and Medical Modelling This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

A physiologically-based flow network model for hepatic drug elimination III: 2D/3D DLA lobule models
One of the major issues in current pharmaceutical development is potential hepatotoxicity and drug-induced liver damage. This is due to the unique metabolic processes performed in the liver to prevent accumula... (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - March 3, 2016 Category: Biomedical Science Authors: Vahid Rezania, Dennis Coombe and Jack A. Tuszynski Source Type: research

Modeling glucose and free fatty acid kinetics in glucose and meal tolerance test
Quantitative evaluation of insulin regulation on plasma glucose and free fatty acid (FFA) in response to external glucose challenge is clinically important to assess the development of insulin resistance (Worl... (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - March 2, 2016 Category: Biomedical Science Authors: Yanjun Li, Carson C. Chow, Amber B. Courville, Anne E. Sumner and Vipul Periwal Source Type: research

Toward precision medicine of breast cancer
In this review, we report on breast cancer’s molecular features and on how high throughput technologies are helping in understanding the dynamics of tumorigenesis and cancer progression with the aim of develop... (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - February 29, 2016 Category: Biomedical Science Authors: Nicolas Carels, Lizânia Borges Spinassé, Tatiana Martins Tilli and Jack Adam Tuszynski Source Type: research

A mathematical model of tumor growth and its response to single irradiation
Mathematical modeling of biological processes is widely used to enhance quantitative understanding of bio-medical phenomena. This quantitative knowledge can be applied in both clinical and experimental setting... (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - February 27, 2016 Category: Biomedical Science Authors: Yoichi Watanabe, Erik L. Dahlman, Kevin Z. Leder and Susanta K. Hui Source Type: research

A group matrix representation relevant to scales of measurement of clinical disease states via stratified vectors
Previously, we applied basic group theory and related concepts to scales of measurement of clinical disease states and clinical findings (including laboratory data). To gain a more concrete comprehension, we h... (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - February 9, 2016 Category: Biomedical Science Authors: Jitsuki Sawamura, Shigeru Morishita and Jun Ishigooka Source Type: research

A cell-centered, agent-based framework that enables flexible environment granularities
Mechanistic explanations of cell-level phenomena typically adopt an observer perspective. Explanations developed from a cell’s perspective may offer new insights. Agent-based models lend themselves to model fr... (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - February 2, 2016 Category: Biomedical Science Authors: Ryan C Kennedy, Glen EP Ropella and C Anthony Hunt Source Type: research

Simulation and qualitative analysis of glucose variability, mean glucose, and hypoglycemia after subcutaneous insulin therapy for stress hyperglycemia
The critically ill can have persistent dysglycemia during the “subacute” recovery phase of their illness because of altered gene expression; it is also not uncommon for these patients to receive continuous ent... (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - January 27, 2016 Category: Biomedical Science Authors: Richard J. Strilka, Mamie C. Stull, Michael S. Clemens, Stewart C. McCaver and Scott B. Armen Source Type: research

Extracting DNA words based on the sequence features: non-uniform distribution and integrity
DNA sequence can be viewed as an unknown language with words as its functional units. Given that most sequence alignment algorithms such as the motif discovery algorithms depend on the quality of background in... (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - January 25, 2016 Category: Biomedical Science Authors: Zhi Li, Hongyan Cao, Yuehua Cui and Yanbo Zhang Source Type: research

Numerical simulations of multicomponent ecological models with adaptive methods
The study of dynamic relationship between a multi-species models has gained a huge amount of scientific interest over the years and will continue to maintain its dominance in both ecology and mathematical ecol... (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - January 8, 2016 Category: Biomedical Science Authors: Kolade M. Owolabi and Kailash C. Patidar Source Type: research

Bioengineering thermodynamics of biological cells
Conclusions: The bioengineering thermodynamics bases are summarized and used to analyse possible controls of the calls behaviours based on the control of the ions fluxes across the cells membranes. (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - December 1, 2015 Category: Biomedical Science Authors: Umberto Lucia Source Type: research

The effect of parameter variability in the allometric projection of leaf growth rates for eelgrass (Zostera marina L.) II: the importance of data quality control procedures in bias reduction
Conclusions: We propose quality control of data as a highly recommended step in the overall procedure that leads to reliable allometric surrogates of eelgrass leaf growth rates. The proliferation of inconsistent replicates in the crude data points towards the importance of discarding incomplete leaves. We also recommend avoiding errors in estimating the biomass of small leaves for which precision of the used analytical scale might be an issue. (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - December 1, 2015 Category: Biomedical Science Authors: Héctor Echavarría-HerasCecilia Leal-RamírezEnrique Villa-DiharceNohe Cazarez-Castro Source Type: research

Modeling optimal treatment strategies in a heterogeneous mixing model
Conclusions: Mixing patterns can play a critical role in the effectiveness of optimal treatments. As the mixing becomes more like-with-like mixing, treating the higher activity group in the population is almost as effective as treating the entire populations since it reduces the number of disease cases effectively but only requires similar treatments. The gain becomes more pronounced as the basic reproduction number increases. This can be a critical issue which must be considered for future pandemic influenza interventions, especially when there are limited resources available. (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - November 25, 2015 Category: Biomedical Science Authors: Seoyun ChoeSunmi Lee Source Type: research

A measure of regularity for polygonal mosaics in biological systems
Conclusions: The measure here proposed has a clear geometrical meaning, establishing what regularity means, and constitute an advantageous general purposes alternative to analyse spatial distributions, capable to indicate the degree of regularity of a mosaic or an array of points. (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - November 16, 2015 Category: Biomedical Science Authors: Gabriela Contreras-FigueroaLuis Hernández-SandovalJosé Aragón Source Type: research

A Boolean network model of human gonadal sex determination
Conclusions: The BNM of GSD that we present summarizes the experimental data on the pathways for Sertoli and granulosa establishment and sheds light on the overall behavior of a population of cells that differentiate within the developing gonad. With this model we propose a set of regulatory interactions needed to activate either the SRY or the WNT4/ β-catenin pathway as well as their downstream targets, which are critical for further sex differentiation. In addition, we observed a pattern of altered regulatory interactions and their dynamics that lead to some disorders of sex development (DSD). (Source: Theoretical Biolo...
Source: Theoretical Biology and Medical Modelling - November 16, 2015 Category: Biomedical Science Authors: Osiris RíosSara FriasAlfredo RodríguezSusana KofmanHoracio MerchantLeda TorresLuis Mendoza Source Type: research

Disc degeneration implies low back pain
Conclusions: Dual testing of the proposed mechanistic model with two independent data sources (one with lumbar MRI and the other without) confirm that disc degeneration is the driving force behind and cause of age dependence in low back pain. Observed complexity of low back pain epidemiology arises from the slow dynamics of disc degeneration coupled with the fast dynamics of disease recurrence. (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - November 9, 2015 Category: Biomedical Science Authors: Chang-Jiang ZhengJames Chen Source Type: research