Theoretical Biology and Medical Modelling This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Application of neural oscillators to study the effects of walking speed on rhythmic activations at the ankle
Conclusion: We showed that SPG in the spinal cord can interpret and respond accordingly to velocity-dependent afferent information. Changes in walking speed do not require a different motor control mechanism provided there is no disruption to the alternating muscular activations generated at the ankle. (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - February 13, 2013 Category: Biomedical Science Authors: Sook-Yee ChongHeiko WagnerArne Wulf Source Type: research

The passage of a diffusible indicator through a microvascular system
Conclusion. (a) The distribution of the time to pass microcirculation by diffusing indicator is given by a compound Poisson distribution; (b) The permeability of tissue-capillary barrier can be obtained from the means, delay, and dispersions of the dilutions of intravascular and diffusing traces. (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - February 13, 2013 Category: Biomedical Science Authors: Victor Kislukhin Source Type: research

Is intracellular pH a clock for mitosis?
Experiments have shown that the intracellular pH of many cells rises to a maximum at the onset of mitosis, subsequently decreasing 0.3 to 0.5 pH units by the end of mitosis. This result, and observations that tubulin net charge depends strongly on pH, may be critical for microtubule (MT) dynamics during mitosis. In vivo studies demonstrate that MT dynamics is sensitive to pH, with MT growth favored by higher pH values. Therefore it seems likely that the shift from the dominance of microtubule growth during prophase, and to a lesser extent during prometaphase, to a parity between MT polymerization and depolymerization durin...
Source: Theoretical Biology and Medical Modelling - February 12, 2013 Category: Biomedical Science Authors: L GagliardiDaniel Shain Source Type: research

Age and gender dependent heart rate circadian model development and performance verification on the proarrhythmic drug case study
Conclusions: It can be concluded that a flexible and practically useful model describing the heart rate circadian variation has been developed and its performance was verified. (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - February 9, 2013 Category: Biomedical Science Authors: Kamil FijorekNikunjkumar Patel¿ukasz KlimaKatarzyna Stolarz-SkrzypekKalina Kawecka-JaszczSebastian Polak Source Type: research

Surgical inflammatory stress: the embryo takes hold of the reins again
The surgical inflammatory response can be a type of high-grade acute stress response associated with an increasingly complex trophic functional system for using oxygen. This systemic neuro-immune-endocrine response seems to induce the re-expression of 2 extraembryonic-like functional axes, i.e. coelomic-amniotic and trophoblastic-yolk-sac-related, within injured tissues and organs, thus favoring their re-development. Accordingly, through the up-regulation of two systemic inflammatory phenotypes, i.e. neurogenic and immune-related, a gestational-like response using embryonic functions would be induced in the patient's injur...
Source: Theoretical Biology and Medical Modelling - February 1, 2013 Category: Biomedical Science Authors: Maria-Angeles AllerJose-Ignacio AriasIsabel PrietoCarlos GilsanzAna AriasHeping YangJaime Arias Source Type: research

Stem cell biology is population biology: differentiation of hematopoietic multipotent progenitors to common lymphoid and myeloid progenitors
The hematopoietic stem cell (HSC) system is a demand control system, with the demand coming from the organism, since the products of the common myeloid and lymphoid progenitor (CMP, CLP respectively) cells are essential for activity and defense against disease. We show how ideas from population biology (combining population dynamics and evolutionary considerations) can illuminate the feedback control of the HSC system by the fully differentiated products, which has recently been verified experimentally. We develop models for the penultimate differentiation of HSC Multipotent Progenitors (MPPs) into CLP and CMP and introduc...
Source: Theoretical Biology and Medical Modelling - January 17, 2013 Category: Biomedical Science Authors: Marc MangelMichael Bonsall Source Type: research

Effectiveness of antiviral prophylaxis coupled with contact tracing in reducing the transmission of the influenza A (H1N1-2009): a systematic review
Conclusions: Only based on the meta-analysis of retrospective studies with different study designs and exposure settings, it was not feasible to estimate the effectiveness of antiviral prophylaxis in reducing transmission. However, modelling analysis of a single outbreak successfully yielded an estimate of the effectiveness that appeared to be robust to model assumptions. Future studies should fill the data gap that has existed in observational studies and allow mathematical models to be used for the analysis of meta-data. (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - January 16, 2013 Category: Biomedical Science Authors: Kenji MizumotoHiroshi NishiuraTaro Yamamoto Source Type: research

Structural, phylogenetic and docking studies of D-amino acid oxidase activator (DAOA), a candidate schizophrenia gene
Conclusion: The predicted interactions might serve to inhibit the disease-related allele. It is assumed that current bioinformatics methods will contribute significantly to identifying, analyzing and curing schizophrenia. There is an urgent need to develop effective drugs for schizophrenia, and tools for examining candidate genes more accurately and efficiently are required. (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - January 4, 2013 Category: Biomedical Science Authors: Sheikh SehgalNaureen KhattakAsif Mir Source Type: research

Review of ‘BipolART’ by D. N. Wheatley (Springer, 2012)
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Source: Theoretical Biology and Medical Modelling - January 3, 2013 Category: Biomedical Science Authors: Paul Agutter Source Type: research

Review of `BipolART¿ by D. N. Wheatley (Springer, 2012)
: (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - January 3, 2013 Category: Biomedical Science Authors: Paul Agutter Source Type: research

Review of 'Bipolart' by D. N. Wheatley (Springer, 2012)
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Source: Theoretical Biology and Medical Modelling - January 3, 2013 Category: Biomedical Science Authors: Paul Agutter Source Type: research

Review of ‘BipolART’ by D. N. Wheatley (Springer, 2012)
(Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - January 3, 2013 Category: Biomedical Science Authors: Paul S Agutter Source Type: research

Erratum to: modelling the correlation between EGFr expression and tumour cell radiosensitivity, and combined treatments of radiation and monoclonal antibody EGFr inhibitors
(Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - August 22, 2012 Category: Biomedical Science Authors: Piernicola Pedicini, Rocchina Caivano, Barbara A Jereczek-Fossa, Lidia Strigari, Barbara Vischioni, Daniela Alterio, Marta Cremonesi, Francesca Botta, Antonio Nappi, Giuseppina Improta, Giovanni Storto, Alba Fiorentino, Marcello Benassi, Roberto Orecchia Source Type: research

Erratum to: Utility of a single adjusting compartment: a novel methodology for whole body physiologically-based pharmacokinetic modelling
After our work was published, we found that some of the terms in the equations were incorrect and that there were some typographical errors in the abbreviations. (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - December 8, 2009 Category: Biomedical Science Authors: Hirotaka Ando, Shigeru Izawa, Wataru Hori and Ippei Nakagawa Source Type: research

The Estradiol-Dihydrotestosterone model of prostate cancer
The exact relationship between hormonal activity and prostate cancer(PCa) has not yet been clearly defined. One of the key hormones associated with PCa is testosterone(T). However, both in vitro and in vivo studi... (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - March 18, 2005 Category: Biomedical Science Authors: A Edward Friedman Source Type: research