Theoretical Biology and Medical Modelling This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Two-dimensional strain-hardening membrane model for large deformation behavior of multiple red blood cells in high shear conditions
Conclusion: The ability of the 2D-LD model to limit RBC strain even at high shear rates enables this proposed model to be employed in practical simulations of high shear rate microfluidic flows such as blood separation channels. (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - May 13, 2014 Category: Biomedical Science Authors: Swe YeYan NgJustin TanHwa LeoSangho Kim Source Type: research

A symmetry model for genetic coding via a wallpaper group composed of the traditional four bases and an imaginary base E: Towards category theory-like systematization of molecular/genetic biology
Conclusions: Despite the large incompleteness of our methodology, there is fertile ground to consider a symmetry model for genetic coding based on our specific wallpaper group. A more integrated formulation containing "central dogma" for future molecular/genetic biology remains to be explored. (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - May 7, 2014 Category: Biomedical Science Authors: Jitsuki SawamuraShigeru MorishitaJun Ishigooka Source Type: research

Cosinor-based rhythmometry
A brief overview is provided of cosinor-based techniques for the analysis of time series in chronobiology. Conceived as a regression problem, the method is applicable to non-equidistant data, a major advantage. Another dividend is the feasibility of deriving confidence intervals for parameters of rhythmic components of known periods, readily drawn from the least squares procedure, stressing the importance of prior (external) information. Originally developed for the analysis of short and sparse data series, the extended cosinor has been further developed for the analysis of long time series, focusing both on rhythm detecti...
Source: Theoretical Biology and Medical Modelling - April 11, 2014 Category: Biomedical Science Authors: Germaine Cornelissen Source Type: research

Computing limits on medicine risks based on collections of individual case reports
Conclusions: Our framework enables quantification of medicine risks in situations where this is otherwise difficultor impossible. It has wide applicability, but should be particularly useful in structured benefit-riskassessments that include rare adverse effects. (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - March 24, 2014 Category: Biomedical Science Authors: Ola CasterNiklas NorénRalph Edwards Source Type: research

Mathematically optimized cryoprotectant equilibration procedures for cryopreservation of human oocytes
Conclusions: The piecewise-constant procedures described in this study are experimentally facile and are predicted to be less toxic than conventional procedures for human oocyte cryopreservation. Moreover, the mathematical optimization approach described here will facilitate the design of cryopreservation procedures for other cell types. (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - March 20, 2014 Category: Biomedical Science Authors: Allyson Fry DavidsonJames BensonAdam Higgins Source Type: research

Chromosome congression explained by nanoscale electrostatics
Nanoscale electrostatic microtubule disassembly forces between positively charged molecules in kinetochores and negative charges on plus ends of microtubules have been implicated in poleward chromosome motions and may also contribute to antipoleward chromosome movements. We propose that chromosome congression can be understood in terms of antipoleward nanoscale electrostatic microtubule assembly forces between negatively charged microtubule plus ends and like-charged chromosome arms, acting in conjunction with poleward microtubule disassembly forces. Several other aspects of post-attachment prometaphase chromosome motions,...
Source: Theoretical Biology and Medical Modelling - February 24, 2014 Category: Biomedical Science Authors: L GagliardiDaniel Shain Source Type: research

Modelling effects of internalized antibody: a simple comparative study
Conclusion: This research will provide a framework for consistent evaluation and comparison of different types of antibodies for toxicological applications. (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - February 13, 2014 Category: Biomedical Science Authors: Vladas SkakauskasPranas KatauskisAlex SkvortsovPeter Gray Source Type: research

A vector-free ECG interpretation with P, QRS & T waves as unbalanced transitions between stable configurations of the heart electric field during P-R, S-T & T-P segments
Since cell membranes are weak sources of electrostatic fields, this ECG interpretation relies on the analogy between cells and electrets. It is here assumed that cell-bound electric fields unite, reach the body surface and the surrounding space and form the thoracic electric field that consists from two concentric structures: the thoracic wall and the heart. If ECG leads measure differences in electric potentials between skin electrodes, they give scalar values that define position of the electric field center along each lead.Repolarised heart muscle acts as a stable positive electric source, while depolarized heart muscle...
Source: Theoretical Biology and Medical Modelling - February 10, 2014 Category: Biomedical Science Authors: Sven Kurbel Source Type: research

Optimization and enhancement of H&E stained microscopical images by applying bilinear interpolation method on lab color mode
Conclusions: Non-uniform illumination problems in H&E microscopical images can be corrected without compromising crucial details that are essential for revealing the features of tissue samples. (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - February 6, 2014 Category: Biomedical Science Authors: Kaya Kuru Source Type: research

How robust are the natural history parameters used in chlamydia transmission dynamic models? A systematic review
In conclusion, authors should use high quality contemporary evidence to inform their parameter values, clearly document their assumptions and make appropriate use of sensitivity analysis. This will help to make models more transparent and increase their utility to policy makers. (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - January 30, 2014 Category: Biomedical Science Authors: Bethan DaviesSarah-Jane AndersonKaty TurnerHelen Ward Source Type: research

A selection criterion for patterns in reaction-diffusion systems
Conclusions: Our criterion is proved rigorously in some situations, generalizing well-known results for the scalar equation where the pattern selection process can be understood in terms of a potential. In more complex settings it is investigated numerically. Our work constitutes a first step towards rigorous pattern prediction in arbitrary geometries/conditions. Advances in this direction are highly applicable to the efficient design of Biotechnology and Developmental Biology experiments, as well as in simplifying the analysis of morphogenetic models. (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - January 29, 2014 Category: Biomedical Science Authors: Tatiana Marquez-LagoPablo Padilla Source Type: research

A selection criterion for patterns in reaction¿diffusion systems
Conclusions: Our criterion is proved rigorously in some situations, generalizing well-known results for the scalar equation where the pattern selection process can be understood in terms of a potential. In more complex settings it is investigated numerically. Our work constitutes a first step towards rigorous pattern prediction in arbitrary geometries/conditions. Advances in this direction are highly applicable to the efficient design of Biotechnology and Developmental Biology experiments, as well as in simplifying the analysis of morphogenetic models. (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - January 29, 2014 Category: Biomedical Science Authors: Tatiana Marquez-LagoPablo Padilla Source Type: research

A model to determine the effect of collagen fiber alignment on heart function post myocardial infarction
Conclusions: The results suggest that cardiac function post-MI is best preserved through increased circumferential compliance. Further, this study identifies several collagen fiber-level mechanisms that could potentially regulate both infarct level and organ level mechanics. Improved understanding of the multi-scale relationships between the ECM and LV function will be beneficial in the design of new diagnostic and therapeutic technologies. (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - January 22, 2014 Category: Biomedical Science Authors: Andrew VoorheesHai-Chao Han Source Type: research

Cost-effective length and timing of school closure during an influenza pandemic depend on the severity
Conclusions: There is no fixed timing and duration of school closure that can be recommended as universal guideline for different types of influenza viruses. The effectiveness of school closure depends on the transmission dynamics of a particular influenza virus strain, especially the virulence (i.e. the infection fatality risk). (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - January 21, 2014 Category: Biomedical Science Authors: Hiroshi NishiuraKeisuke EjimaKenji MizumotoShinji NakaokaHisashi InabaSeiya ImotoRui YamaguchiMasaya Saito Source Type: research

A model of hematopoietic stem cell proliferation under the influence of a chemotherapeutic agent in combination with a hematopoietic inducing agent
Conclusions: The proposed model indicates that the introduction of hematopoietic inducing agents have clinical potential to offset the deleterious effects of chemotherapy treatment. Furthermore, the proposed model is relevant in that it enhances the understanding of stem cell dynamics and provides insight on the stem cell kinetics. (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - January 17, 2014 Category: Biomedical Science Authors: Christina MouserEliana AntoniouEvros VassiliouJames Tadros Source Type: research