A Boolean network model of human gonadal sex determination
Conclusions:
The BNM of GSD that we present summarizes the experimental data on the pathways for Sertoli and granulosa establishment and sheds light on the overall behavior of a population of cells that differentiate within the developing gonad. With this model we propose a set of regulatory interactions needed to activate either the SRY or the WNT4/ β-catenin pathway as well as their downstream targets, which are critical for further sex differentiation. In addition, we observed a pattern of altered regulatory interactions and their dynamics that lead to some disorders of sex development (DSD).
Source: Theoretical Biology and Medical Modelling - Category: Biomedical Science Authors: Osiris RíosSara FriasAlfredo RodríguezSusana KofmanHoracio MerchantLeda TorresLuis Mendoza Source Type: research