Determination of the optimal tubulin isotype target as a method for the development of individualized cancer chemotherapy

Conclusions: Our algorithm, which defines the best profile for each type of cancer (given the drug delivery route and some specified patient characteristics), will help to personalize the design of pharmaceuticals for individual patients. This paper is an attempt to explicitly consider the effects of the tubulin isotype distributions in both cancer and normal cell types, for rational chemotherapy design aimed at optimizing the drug's efficacy with minimal side effects.
Source: Theoretical Biology and Medical Modelling - Category: Biomedical Science Authors: Source Type: research