Table of Contents
(Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - October 27, 2016 Category: Infectious Diseases Tags: Cover/Standing Material Source Type: research
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(Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - October 27, 2016 Category: Infectious Diseases Tags: Cover/Standing Material Source Type: research
Masthead
(Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - October 27, 2016 Category: Infectious Diseases Tags: Cover/Standing Material Source Type: research
Editorial Board
(Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - October 27, 2016 Category: Infectious Diseases Tags: Cover/Standing Material Source Type: research
Editorial Advisory Board
(Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - October 27, 2016 Category: Infectious Diseases Tags: Cover/Standing Material Source Type: research
Cover
(Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - October 27, 2016 Category: Infectious Diseases Tags: Cover/Standing Material Source Type: research
Hader (J Infect Dis 2016; 213[suppl 2]:S34)
(Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - October 12, 2016 Category: Infectious Diseases Tags: ERRATUM Source Type: research
Blockade of the Kv1.3 K+ Channel Enhances BCG Vaccine Efficacy by Expanding Central Memory T Lymphocytes
Tuberculosis is the oldest known infectious disease, yet there is no effective vaccine against adult pulmonary tuberculosis. Emerging evidence indicates that T-helper 1 and T-helper 17 cells play important roles in host protection against tuberculosis. However, tuberculosis vaccine efficacy in mice is critically dependent on the balance between antigen-specific central memory T (Tcm) and effector memory T (Tem) cells. Specifically, a high Tcm/Tem cell ratio is essential for optimal vaccine efficacy. Here, we show that inhibition of Kv1.3, a potassium channel preferentially expressed by Tem cells, by Clofazimine selectively...
Source: The Journal of Infectious Diseases - October 12, 2016 Category: Infectious Diseases Authors: Singh, D. K., Dwivedi, V. P., Ranganathan, A., Bishai, W. R., Van Kaer, L., Das, G. Tags: PATHOGENESIS AND HOST RESPONSE Source Type: research
Surfactant Protein A Recognizes Outer Membrane Protein OprH on Pseudomonas aeruginosa Isolates From Individuals With Chronic Infection
Surfactant protein A (SP-A) plays a critical role in the clearance of Pseudomonas aeruginosa from the lung. However, there is limited information about the interaction of this protein with P. aeruginosa isolates from individuals with cystic fibrosis (CF). We characterized the interplay between SP-A and a collection of isogenic sequential isolates from 7 patients with CF. We identified outer membrane protein OprH as a novel ligand for SP-A on P. aeruginosa. The last-available (late) isolates from patients with CF bound significantly less SP-A than their respective first-available (early) isolates. This difference could be a...
Source: The Journal of Infectious Diseases - October 12, 2016 Category: Infectious Diseases Authors: Qadi, M., Lopez-Causape, C., Izquierdo-Rabassa, S., Mateu Borras, M., Goldberg, J. B., Oliver, A., Alberti, S. Tags: PATHOGENESIS AND HOST RESPONSE Source Type: research
During Hepatitis C Virus (HCV) Infection and HCV-HIV Coinfection, an Elevated Plasma Level of Autotaxin Is Associated With Lysophosphatidic Acid and Markers of Immune Activation That Normalize During Interferon-Free HCV Therapy
Conclusions. These data indicate that elevated levels of autotaxin and soluble markers of immune activation during HCV infection are partially reversible within 6 months of initiating interferon-free HCV treatment and that autotaxin may be causally linked to immune activation during HCV infection and HCV-HIV coinfection. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - October 12, 2016 Category: Infectious Diseases Authors: Kostadinova, L., Shive, C. L., Judge, C., Zebrowski, E., Compan, A., Rife, K., Hirsch, A., Falck-Ytter, Y., Schlatzer, D. M., Li, X., Chance, M. R., Rodriguez, B., Popkin, D. L., Anthony, D. D. Tags: PATHOGENESIS AND HOST RESPONSE Source Type: research
Functional Diversity of Cytomegalovirus-Specific T Cells Is Maintained in Older People and Significantly Associated With Protein Specificity and Response Size
Discussion. Our results give a new perspective on T-cell polyfunctionality and raise the question of whether maintaining polyfunctionality of CMV-specific T cells at older ages is necessarily beneficial. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - October 12, 2016 Category: Infectious Diseases Authors: Bajwa, M., Vita, S., Vescovini, R., Larsen, M., Sansoni, P., Terrazzini, N., Caserta, S., Thomas, D., Davies, K. A., Smith, H., Kern, F. Tags: PATHOGENESIS AND HOST RESPONSE Source Type: research
The Global Regulon sarA Regulates {beta}-Lactam Antibiotic Resistance in Methicillin-Resistant Staphylococcus aureus In Vitro and in Endovascular Infections
Conclusions. These results suggested that sarA regulates oxacillin resistance in mecA-positive MRSA. Thus, abrogation of this regulator represents an attractive and novel drug target to potentiate efficacy of existing antibiotic for MRSA therapy. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - October 12, 2016 Category: Infectious Diseases Authors: Li, L., Cheung, A., Bayer, A. S., Chen, L., Abdelhady, W., Kreiswirth, B. N., Yeaman, M. R., Xiong, Y. Q. Tags: BACTERIA Source Type: research
Density, Serotype Diversity, and Fitness of Streptococcus pneumoniae in Upper Respiratory Tract Cocolonization With Nontypeable Haemophilus influenzae
Conclusions. Pneumococcal-NTHi cocolonization is associated with an elevated density of both species and with reduced diversity and increased fitness of pneumococcal serotypes. NTHi colonization may create a selective environment favoring pneumococci with immune-evasive phenotypes. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - October 12, 2016 Category: Infectious Diseases Authors: Lewnard, J. A., Huppert, A., Givon-Lavi, N., Pettigrew, M. M., Regev-Yochay, G., Dagan, R., Weinberger, D. M. Tags: BACTERIA Source Type: research
Severe Flooding and Malaria Transmission in the Western Ugandan Highlands: Implications for Disease Control in an Era of Global Climate Change
Conclusions. Extreme precipitation such as the flooding described here may pose significant challenges to malaria control programs and will demand timely responses to mitigate deleterious impacts on human health. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - October 12, 2016 Category: Infectious Diseases Authors: Boyce, R., Reyes, R., Matte, M., Ntaro, M., Mulogo, E., Metlay, J. P., Band, L., Siedner, M. J. Tags: PARASITES Source Type: research
Viral Genome Sequencing Proves Nosocomial Transmission of Fatal Varicella
We report the first use of whole viral genome sequencing to identify nosocomial transmission of varicella-zoster virus with fatal outcome. The index case patient, nursed in source isolation, developed disseminated zoster with rash present for 1 day before being transferred to the intensive care unit (ICU). Two patients who had received renal transplants while inpatients in an adjacent ward developed chickenpox and 1 died; neither patient had direct contact with the index patient. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - October 12, 2016 Category: Infectious Diseases Authors: Depledge, D. P., Brown, J., Macanovic, J., Underhill, G., Breuer, J. Tags: VIRUSES Source Type: research
