Cover
(Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - September 12, 2016 Category: Infectious Diseases Tags: Cover/Standing Material Source Type: research
Payne et al (J Infect Dis 2016; 213:1743-51)
(Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - August 23, 2016 Category: Infectious Diseases Tags: ERRATUM Source Type: research
Adjunctive Corticosteroid Treatment Against Yersinia pestis Improves Bacterial Clearance, Immunopathology, and Survival in the Mouse Model of Bubonic Plague
Conclusions. Corticosteroids induce an unexpectedly effective antibacterial response apart from their antiinflammatory properties, thereby improving treatment efficacy. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - August 23, 2016 Category: Infectious Diseases Authors: Levy, Y., Vagima, Y., Tidhar, A., Zauberman, A., Aftalion, M., Gur, D., Fogel, I., Chitlaru, T., Flashner, Y., Mamroud, E. Tags: PATHOGENESIS AND HOST RESPONSE Source Type: research
Type III Secretion System of Pseudomonas aeruginosa Affects Matrix Metalloproteinase 12 (MMP-12) and MMP-13 Expression via Nuclear Factor {kappa}B Signaling in Human Carcinoma Epithelial Cells and a Pneumonia Mouse Model
We examined the effects of ExoS, ExoT, and ExsA:: on MMP-12 and MMP-13 production in NCI-H292 cells. ExoS and ExoT markedly decreased the neutrophil count in bronchoalveolar lavage fluid, with a reduction in proinflammatory mediators, MMP-12, and MMP-13. ExoS and ExoT reduced NF-B phosphorylation, together with MMP-12 and MMP-13 expression in PAK-infected mouse models and NCI-H292 cells. To conclude, P. aeruginosa infection induced the expression of MMPs, and P. aeruginosa T3SS appeared to be a key player in MMP-12 and MMP-13 expression, which is further controlled by NF-B signaling. These findings might be useful in devis...
Source: The Journal of Infectious Diseases - August 23, 2016 Category: Infectious Diseases Authors: Park, J.-W., Kim, Y.-J., Shin, I.-S., Kwon, O.-K., Hong, J. M., Shin, N.-R., Oh, S.-R., Ha, U.-H., Kim, J.-H., Ahn, K.-S. Tags: PATHOGENESIS AND HOST RESPONSE Source Type: research
Thioredoxins and Methionine Sulfoxide Reductases in the Pathophysiology of Pneumococcal Meningitis
Conclusions. Our data support the importance of the extracellular redox repair system in virulence and its potential as a target for the design of new antimicrobials and vaccine formulations against Streptococcus pneumoniae. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - August 23, 2016 Category: Infectious Diseases Authors: Ribes, S., Abdullah, M. R., Saleh, M., Hanisch, U.-K., Nau, R., Hammerschmidt, S. Tags: PATHOGENESIS AND HOST RESPONSE Source Type: research
Generation and Protective Ability of Influenza Virus-Specific Antibody-Dependent Cellular Cytotoxicity in Humans Elicited by Vaccination, Natural Infection, and Experimental Challenge
Conclusions. ADCC-Ab titers increased following experimental influenza virus infection in adults and after ISV administration in both children and adults. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - August 23, 2016 Category: Infectious Diseases Authors: Jegaskanda, S., Luke, C., Hickman, H. D., Sangster, M. Y., Wieland-Alter, W. F., McBride, J. M., Yewdell, J. W., Wright, P. F., Treanor, J., Rosenberger, C. M., Subbarao, K. Tags: PATHOGENESIS AND HOST RESPONSE Source Type: research
Blocking of CD1d Decreases Trypanosoma cruzi-Induced Activation of CD4-CD8- T Cells and Modulates the Inflammatory Response in Patients With Chagas Heart Disease
The control of inflammatory responses to prevent the deadly cardiac pathology in human Chagas disease is a desirable and currently unattained goal. Double-negative (DN) T cells are important sources of inflammatory and antiinflammatory cytokines in patients with Chagas heart disease and those with the indeterminate clinical form of Chagas disease, respectively. Given the importance of DN T cells in immunoregulatory processes and their potential as targets for controlling inflammation-induced pathology, we studied the involvement of CD1 molecules in the activation and functional profile of Trypanosoma cruzi–specific D...
Source: The Journal of Infectious Diseases - August 23, 2016 Category: Infectious Diseases Authors: Passos, L. S. A., Villani, F. N. A., Magalhaes, L. M. D., Gollob, K. J., Antonelli, L. R. d. V., Nunes, M. C. P., Dutra, W. O. Tags: PATHOGENESIS AND HOST RESPONSE Source Type: research
Streptococcus oralis and Candida albicans Synergistically Activate {mu}-Calpain to Degrade E-cadherin From Oral Epithelial Junctions
In this study, using oral epithelial cultures, organotypic oral mucosal constructs, and a mouse model of oral infection, we demonstrated that S. oralis augmented C. albicans invasion through epithelial junctions. C. albicans and S. oralis decreased epithelial E-cadherin levels by synergistically increasing µ-calpain, a proteolytic enzyme that targets E-cadherin. In the mouse coinfection model this was accompanied by increased fungal kidney dissemination. Coinfection with a secreted aspartyl protease (sap) mutant sap2456 and S. oralis increased μ-calpain and triggered mucosal invasion and systemic dissemination, su...
Source: The Journal of Infectious Diseases - August 23, 2016 Category: Infectious Diseases Authors: Xu, H., Sobue, T., Bertolini, M., Thompson, A., Dongari-Bagtzoglou, A. Tags: PATHOGENESIS AND HOST RESPONSE Source Type: research
The Bacterial Stress-Responsive Hsp90 Chaperone (HtpG) Is Required for the Production of the Genotoxin Colibactin and the Siderophore Yersiniabactin in Escherichia coli
The genotoxin colibactin, synthesized by Escherichia coli, is a secondary metabolite belonging to the chemical family of hybrid polyketide/nonribosomal peptide compounds. It is produced by a complex biosynthetic assembly line encoded by the pks pathogenicity island. The presence of this large cluster of genes in the E. coli genome is invariably associated with the high-pathogenicity island, encoding the siderophore yersiniabactin, which belongs to the same chemical family as colibactin. The E. coli heat shock protein HtpG (Hsp90Ec) is the bacterial homolog of the eukaryotic molecular chaperone Hsp90, which is involved in t...
Source: The Journal of Infectious Diseases - August 23, 2016 Category: Infectious Diseases Authors: Garcie, C., Tronnet, S., Garenaux, A., McCarthy, A. J., Brachmann, A. O., Penary, M., Houle, S., Nougayrede, J.-P., Piel, J., Taylor, P. W., Dozois, C. M., Genevaux, P., Oswald, E., Martin, P. Tags: BACTERIA Source Type: research
Endotoxin Tolerance Inhibits Degradation of Tumor Necrosis Factor Receptor-Associated Factor 3 by Suppressing Pellino 1 Expression and the K48 Ubiquitin Ligase Activity of Cellular Inhibitor of Apoptosis Protein 2
In this study, we found that lipopolysaccharide (LPS) stimulation decreased TARF3 protein expression in mouse Kupffer cells (KCs) and liver tissues, whereas endotoxin tolerization abrogated this effect. Degradative TRAF3 K48–linked ubiquitination and the cytoplasmic translocation of the MYD88-associated multiprotein complex were significantly inhibited in tolerized KCs, which led to markedly impaired activation of MYD88-dependent JNK and p38 and downregulation of inflammatory cytokines. TRAF3 ablation failed to induce a fully endotoxin-tolerant state in RAW264.7 cells. Pellino 1 knockdown in Raw264.7 cells did not im...
Source: The Journal of Infectious Diseases - August 23, 2016 Category: Infectious Diseases Authors: Li, P., Liu, H., Zhang, Y., Liao, R., He, K., Ruan, X., Gong, J. Tags: BACTERIA Source Type: research
Intrahost Evolution of Methicillin-Resistant Staphylococcus aureus USA300 Among Individuals With Reoccurring Skin and Soft-Tissue Infections
Discussions. During a 5-year period in 4 subjects, we identified development of antimicrobial resistance, intrahost evolution, and strain replacement among isolates from patients with recurrent MRSA infections. This calls into question the efficacy of decolonization to prevent recurrent infections and highlights the adaptive potential of USA300 and the need for effective sampling. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - August 23, 2016 Category: Infectious Diseases Authors: Azarian, T., Daum, R. S., Petty, L. A., Steinbeck, J. L., Yin, Z., Nolan, D., Boyle-Vavra, S., Hanage, W. P., Salemi, M., David, M. Z. Tags: BACTERIA Source Type: research
Sporozoite Route of Infection Influences In Vitro var Gene Transcription of Plasmodium falciparum Parasites From Controlled Human Infections
Conclusions. The duration of intrahost replication influences in vitro var gene transcript patterns. Differences between premosquito and postpatient cultures decrease with prolonged in vitro growth. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - August 23, 2016 Category: Infectious Diseases Authors: Dimonte, S., Bruske, E. I., Hass, J., Supan, C., Salazar, C. L., Held, J., Tschan, S., Esen, M., Flötenmeyer, M., Koch, I., Berger, J., Bachmann, A., Sim, B. K. L., Hoffman, S. L., Kremsner, P. G., Mordmüller, B., Frank, M. Tags: PARASITES Source Type: research
Protease Inhibitor Resistance in the First 3 Years of Second-Line Antiretroviral Therapy for HIV-1 in Sub-Saharan Africa
Conclusions. Although VL suppression rates were high, PI resistance was detected in 22% of participants with VLs ≥1000 cps/mL. To ensure long-term ART success, intensified support for adherence, VL and drug resistance testing, and third-line drugs will be necessary. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - August 23, 2016 Category: Infectious Diseases Authors: Boender, T. S., Hamers, R. L., Ondoa, P., Wellington, M., Chimbetete, C., Siwale, M., Labib Maksimos, E. E. F., Balinda, S. N., Kityo, C. M., Adeyemo, T. A., Akanmu, A. S., Mandaliya, K., Botes, M. E., Stevens, W., Rinke de Wit, T. F., Sigaloff, K. C. E. Tags: HIV/AIDS Source Type: research
Incidence of AIDS-Defining Opportunistic Infections in a Multicohort Analysis of HIV-infected Persons in the United States and Canada, 2000-2010
Conclusions. For HIV-infected persons in care during 2000–2010, rates of first OI were relatively low and generally declined over this time. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - August 23, 2016 Category: Infectious Diseases Authors: Buchacz, K., Lau, B., Jing, Y., Bosch, R., Abraham, A. G., Gill, M. J., Silverberg, M. J., Goedert, J. J., Sterling, T. R., Althoff, K. N., Martin, J. N., Burkholder, G., Gandhi, N., Samji, H., Patel, P., Rachlis, A., Thorne, J. E., Napravnik, S., Henry, Tags: HIV/AIDS Source Type: research
Public Health Benefits of Routine Human Papillomavirus Vaccination for Adults in the Netherlands: A Mathematical Modeling Study
Conclusions. Offering vaccination to adults, especially at cervical cancer screening visits (for women) and during STI consultations (for both sexes), would substantially reduce HPV incidence and would be an efficient policy option to improve HPV prevention and subsequently avert cervical and possibly male HPV-related cancers. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - August 23, 2016 Category: Infectious Diseases Authors: Matthijsse, S. M., Hontelez, J. A. C., Naber, S. K., Rozemeijer, K., de Kok, I. M. C. M., Bakker, R., van Ballegooijen, M., van Rosmalen, J., de Vlas, S. J. Tags: VIRUSES Source Type: research
