Persistent Inflammation in Treated HIV Disease
(Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - September 12, 2016 Category: Infectious Diseases Authors: Sieg, S. F. Tags: PERSISTENT INFLAMMATION IN TREATED HIV DISEASE Source Type: research
Matsumiya et al (J Infect Dis 2015; 211:1499-509)
(Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - September 12, 2016 Category: Infectious Diseases Tags: ERRATA Source Type: research
Bhattacharya et al (J Infect Dis 2016; 214:196-204)
(Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - September 12, 2016 Category: Infectious Diseases Tags: ERRATA Source Type: research
Armah et al (J Infect Dis 2016; 213:1678-85)
(Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - September 12, 2016 Category: Infectious Diseases Tags: ERRATA Source Type: research
Ockham's Razor and the PrePex Male Circumcision Device
(Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - September 12, 2016 Category: Infectious Diseases Authors: Liu, C. M., Tobian, A. A. R., Gray, R. H. Tags: CORRESPONDENCE Source Type: research
Genital Anaerobic Bacterial Overgrowth and the PrePex Male Circumcision Device, Rakai, Uganda
(Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - September 12, 2016 Category: Infectious Diseases Authors: Brook, I. Tags: CORRESPONDENCE Source Type: research
HLA-DRB1 Alleles Are Associated With Different Magnitudes of Dengue Virus-Specific CD4+ T-Cell Responses
Conclusions. Comprehensive identification of unique CD4+ T-cell epitopes across the 4 DENV serotypes allows the testing of T-cell responses by use of a simple, approachable technique and points to important implications for vaccine design. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - September 12, 2016 Category: Infectious Diseases Authors: Weiskopf, D., Angelo, M. A., Grifoni, A., O'Rourke, P. H., Sidney, J., Paul, S., De Silva, A. D., Phillips, E., Mallal, S., Premawansa, S., Premawansa, G., Wijewickrama, A., Peters, B., Sette, A. Tags: PATHOGENESIS AND HOST RESPONSE Source Type: research
Inhibition of the Injectisome and Flagellar Type III Secretion Systems by INP1855 Impairs Pseudomonas aeruginosa Pathogenicity and Inflammasome Activation
With the rise of multidrug resistance, Pseudomonas aeruginosa infections require alternative therapeutics. The injectisome (iT3SS) and flagellar (fT3SS) type III secretion systems are 2 virulence factors associated with poor clinical outcomes. iT3SS translocates toxins, rod, needle, or regulator proteins, and flagellin into the host cell cytoplasm and causes cytotoxicity and NLRC4-dependent inflammasome activation, which induces interleukin 1β (IL–1β) release and reduces interleukin 17 (IL-17) production and bacterial clearance. fT3SS ensures bacterial motility, attachment to the host cells, and triggers in...
Source: The Journal of Infectious Diseases - September 12, 2016 Category: Infectious Diseases Authors: Anantharajah, A., Faure, E., Buyck, J. M., Sundin, C., Lindmark, T., Mecsas, J., Yahr, T. L., Tulkens, P. M., Mingeot-Leclercq, M.-P., Guery, B., Van Bambeke, F. Tags: PATHOGENESIS AND HOST RESPONSE Source Type: research
Escherichia coli K1 Modulates Peroxisome Proliferator-Activated Receptor {gamma} and Glucose Transporter 1 at the Blood-Brain Barrier in Neonatal Meningitis
Escherichia coli K1 meningitis continues to be a major threat to neonatal health. Previous studies demonstrated that outer membrane protein A (OmpA) of E. coli K1 interacts with endothelial cell glycoprotein 96 (Ecgp96) in the blood-brain barrier to enter the central nervous system. Here we show that the interaction between OmpA and Ecgp96 downregulates peroxisome proliferator–activated receptor (PPAR-) and glucose transporter 1 (GLUT-1) levels in human brain microvascular endothelial cells, causing disruption of barrier integrity and inhibition of glucose uptake. The suppression of PPAR- and GLUT-1 by the bacteria i...
Source: The Journal of Infectious Diseases - September 12, 2016 Category: Infectious Diseases Authors: Krishnan, S., Chang, A. C., Stoltz, B. M., Prasadarao, N. V. Tags: BACTERIA Source Type: research
Whole-Genome Sequencing to Evaluate the Resistance Landscape Following Antimalarial Treatment Failure With Fosmidomycin-Clindamycin
Novel antimalarial therapies are needed in the face of emerging resistance to artemisinin combination therapies. A previous study found a high cure rate in Mozambican children with uncomplicated Plasmodium falciparum malaria 7 days after combination treatment with fosmidomycin-clindamycin. However, 28-day cure rates were low (45.9%), owing to parasite recrudescence. We sought to identify any genetic changes underlying parasite recrudescence. To this end, we used a selective whole-genome amplification method to amplify parasite genomes from blood spot DNA samples. Parasite genomes from pretreatment and postrecrudescence sam...
Source: The Journal of Infectious Diseases - September 12, 2016 Category: Infectious Diseases Authors: Guggisberg, A. M., Sundararaman, S. A., Lanaspa, M., Moraleda, C., Gonzalez, R., Mayor, A., Cistero, P., Hutchinson, D., Kremsner, P. G., Hahn, B. H., Bassat, Q., Odom, A. R. Tags: PARASITES Source Type: research
Reticulocyte Preference and Stage Development of Plasmodium vivax Isolates
Plasmodium vivax, the most widely distributed human malaria parasite, is restricted to reticulocytes, limiting its asexual proliferation. In recent years, cases of severe and high-level P. vivax parasitemia have been reported, challenging the assumption that all isolates are equally restricted. In this article, we analyze the reticulocyte preference of a large number of Indian P. vivax isolates. Our results show that P. vivax isolates significantly vary in their level of reticulocyte preference. In addition, by carefully staging the parasites, we find that P. vivax schizonts are largely missing in peripheral blood, with th...
Source: The Journal of Infectious Diseases - September 12, 2016 Category: Infectious Diseases Authors: Lim, C., Pereira, L., Saliba, K. S., Mascarenhas, A., Maki, J. N., Chery, L., Gomes, E., Rathod, P. K., Duraisingh, M. T. Tags: PARASITES Source Type: research
Quantifying Heterogeneous Malaria Exposure and Clinical Protection in a Cohort of Ugandan Children
Conclusions. Heterogeneity in P. falciparum exposure and immunity can be independently evaluated using detailed longitudinal studies. Improved understanding of the factors driving immunity will provide key information to anticipate the impact of malaria-control interventions and to understand the mechanisms of clinical immunity. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - September 12, 2016 Category: Infectious Diseases Authors: Rodriguez-Barraquer, I., Arinaitwe, E., Jagannathan, P., Boyle, M. J., Tappero, J., Muhindo, M., Kamya, M. R., Dorsey, G., Drakeley, C., Ssewanyana, I., Smith, D. L., Greenhouse, B. Tags: PARASITES Source Type: research
Hormonal Contraceptive Use Among HIV-Positive Women and HIV Transmission Risk to Male Partners, Zambia, 1994-2012
Conclusions. Our findings suggest null associations between hormonal contraception and risk of female-to-male HIV transmission. We support efforts to increase the contraceptive method mix for all women, regardless of HIV serostatus, along with reinforced condom counseling for HIV-serodiscordant couples. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - September 12, 2016 Category: Infectious Diseases Authors: Wall, K. M., Kilembe, W., Vwalika, B., Ravindhran, P., Khu, N. H., Brill, I., Chomba, E., Johnson, B. A., Haddad, L. B., Tichacek, A., Allen, S. Tags: HIV/AIDS Source Type: research
Chemoprophylaxis With Oral Emtricitabine and Tenofovir Alafenamide Combination Protects Macaques From Rectal Simian/Human Immunodeficiency Virus Infection
Tenofovir alafenamide (TAF) is a novel prodrug of tenofovir that efficiently delivers tenofovir diphosphate to lymphoid cells following oral administration. We investigated whether the combination of TAF and emtricitabine (FTC) could prevent simian/human immunodeficiency virus (SHIV) infection in macaques to determine the potential use of TAF for pre-exposure prophylaxis (PrEP) to prevent human immunodeficiency virus infection. Macaques were exposed rectally to SHIV once per week for up to 19 weeks and received saline or FTC/TAF 24 hours before and 2 hours after each virus inoculation. All 6 controls were infected, while t...
Source: The Journal of Infectious Diseases - September 12, 2016 Category: Infectious Diseases Authors: Massud, I., Mitchell, J., Babusis, D., Deyounks, F., Ray, A. S., Rooney, J. F., Heneine, W., Miller, M. D., Garcia-Lerma, J. G. Tags: HIV/AIDS Source Type: research
Low Risk of Proximal Tubular Dysfunction Associated With Emtricitabine-Tenofovir Disoproxil Fumarate Preexposure Prophylaxis in Men and Women
Conclusions. Daily oral FTC-TDF PrEP was not significantly associated with tubulopathy over the course of 24 months, nor did tubulopathy predict clinically relevant eGFR decline. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - September 12, 2016 Category: Infectious Diseases Authors: Mugwanya, K., Baeten, J., Celum, C., Donnell, D., Nickolas, T., Mugo, N., Branch, A., Tappero, J., Kiarie, J., Ronald, A., Yin, M., Wyatt, C., for the Partners PrEP Study Team, Celum, Baeten, Donnell, Coombs, Frenkel, Hendrix, Lingappa, McElrath, Kenya, F Tags: HIV/AIDS Source Type: research
