HLA-DRB1 Alleles Are Associated With Different Magnitudes of Dengue Virus-Specific CD4+ T-Cell Responses

Conclusions. Comprehensive identification of unique CD4+ T-cell epitopes across the 4 DENV serotypes allows the testing of T-cell responses by use of a simple, approachable technique and points to important implications for vaccine design.

Source: The Journal of Infectious Diseases - September 12, 2016 Category: Infectious Diseases Authors: Weiskopf, D., Angelo, M. A., Grifoni, A., O'Rourke, P. H., Sidney, J., Paul, S., De Silva, A. D., Phillips, E., Mallal, S., Premawansa, S., Premawansa, G., Wijewickrama, A., Peters, B., Sette, A. Tags: PATHOGENESIS AND HOST RESPONSE Source Type: research