During Hepatitis C Virus (HCV) Infection and HCV-HIV Coinfection, an Elevated Plasma Level of Autotaxin Is Associated With Lysophosphatidic Acid and Markers of Immune Activation That Normalize During Interferon-Free HCV Therapy

Conclusions. These data indicate that elevated levels of autotaxin and soluble markers of immune activation during HCV infection are partially reversible within 6 months of initiating interferon-free HCV treatment and that autotaxin may be causally linked to immune activation during HCV infection and HCV-HIV coinfection.

Source: The Journal of Infectious Diseases - October 12, 2016 Category: Infectious Diseases Authors: Kostadinova, L., Shive, C. L., Judge, C., Zebrowski, E., Compan, A., Rife, K., Hirsch, A., Falck-Ytter, Y., Schlatzer, D. M., Li, X., Chance, M. R., Rodriguez, B., Popkin, D. L., Anthony, D. D. Tags: PATHOGENESIS AND HOST RESPONSE Source Type: research