The Global Regulon sarA Regulates {beta}-Lactam Antibiotic Resistance in Methicillin-Resistant Staphylococcus aureus In Vitro and in Endovascular Infections

Conclusions. These results suggested that sarA regulates oxacillin resistance in mecA-positive MRSA. Thus, abrogation of this regulator represents an attractive and novel drug target to potentiate efficacy of existing antibiotic for MRSA therapy.

Source: The Journal of Infectious Diseases - October 12, 2016 Category: Infectious Diseases Authors: Li, L., Cheung, A., Bayer, A. S., Chen, L., Abdelhady, W., Kreiswirth, B. N., Yeaman, M. R., Xiong, Y. Q. Tags: BACTERIA Source Type: research