Introduction.
Authors: Stein Gold LF PMID: 27074694 [PubMed - as supplied by publisher] (Source: Seminars in Cutaneous Medicine and Surgery)
Source: Seminars in Cutaneous Medicine and Surgery - April 15, 2016 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research

Topical Therapies for Psoriasis: Improving Management Strategies and Patient Adherence.
Authors: Stein Gold LF Abstract Psoriasis is a chronic disease that has a substantial effect on quality of life of patients and often needs long-term treatment. Topical treatments for psoriasis include corticosteroids, vitamin D derivatives, tazarotene, anthralin, tacrolimus, pimecrolimus, and newer formulations of tar. Although many of these treatments are effective, they must be prescribed appropriately and used consistently for a period of weeks to months before clinical evidence of improvement can be seen and patients perceive that the treatment is working. As such, medication dosage/schedule, choice o...
Source: Seminars in Cutaneous Medicine and Surgery - April 15, 2016 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research

Understanding Onychomycosis Resolving Diagnostic Dilemmas.
Authors: Stein Gold LF Abstract No scientifically rigorous, large, prospective studies have been done to document the true prevalence of onychomycosis; the reported rates vary mainly by climate and by population, but the overall prevalence in the United States is estimated to be at least 10%. Advanced age and diabetes are the most commonly reported risk factors for onychomycosis. The differential diagnosis of onychomycosis is lengthy, and visual inspection alone is not sufficient for a definitive diagnosis-direct microscopic examination of a wet-mount preparation with 10% to 20% potassium hydroxide is the ...
Source: Seminars in Cutaneous Medicine and Surgery - April 15, 2016 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research

Antifungal Drugs for Onychomycosis: Efficacy, Safety, and Mechanisms of Action.
Authors: Rosen T, Stein Gold LF Abstract In 1996, oral terbinafine joined itraconazole and fluconazole on the short list of systemic medications that could be used to treat onychomycosis (although fluconazole was not approved for this indication by the US Food and Drug Administration [FDA], it was commonly used for this purpose). In 1999, ciclopirox was the first topical treatment to be FDA approved. The addition of the topical antifungal agents efinaconazole and tavaborole in 2014 expanded the roster of medications available to more effectively manage onychomycosis in a wide range of patients, including t...
Source: Seminars in Cutaneous Medicine and Surgery - April 15, 2016 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research

Concepts in Onychomycosis Treatment and Recurrence Prevention: An Update.
Authors: Rosen T Abstract In considering therapy for onychomycosis, the most important factor to take into account is patient selection rather than treatment selection. Patients should be screened and evaluated for the extent of nail involvement, the amount of subungual debris, the degree of dystrophy, their ability and willingness to follow the regimen, and whether comorbidities are present that may affect the efficacy and/or safety of one or more therapies. Onychomycosis is a chronic disease with a high recurrence rate. Commonsense measures to reduce the risk for reinfection include patient education and...
Source: Seminars in Cutaneous Medicine and Surgery - April 15, 2016 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research

Imaging in Dermatology. Introduction.
Authors: Rossi AM PMID: 26963109 [PubMed - in process] (Source: Seminars in Cutaneous Medicine and Surgery)
Source: Seminars in Cutaneous Medicine and Surgery - March 12, 2016 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research

Current state of imaging in dermatology.
Authors: Hibler BP, Qi Q, Rossi AM Abstract Medical imaging has dramatically transformed the practice of medicine, especially the field of dermatology. Imaging is used to facilitate the transfer of information between providers, document cutaneous disease, assess response to therapy, and plays a crucial role in monitoring and diagnosing skin cancer. Advancements in imaging technology and overall improved quality of imaging have augmented the utility of photography. We provide an overview of current imaging technologies used in dermatology with a focus on their role in skin cancer diagnosis. Future technolo...
Source: Seminars in Cutaneous Medicine and Surgery - March 12, 2016 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research

The role of imaging in the prevention of wrong-site surgery in dermatology.
Authors: Harker DB, Mollet T, Srivastava D, Nijhawan RI Abstract Wrong-site surgery in dermatology often results from inaccurate identification of a skin cancer biopsy site. Factors making biopsy-site identification difficult include background actinic damage, delays from biopsy to surgery, and lack of photographic documentation. While other methods exist for biopsy-site identification, photography is the most helpful tool available. Although modern technology has made high-quality photographic equipment ubiquitous and easy to use, photography for biopsy-site identification continues to be underutilized. T...
Source: Seminars in Cutaneous Medicine and Surgery - March 12, 2016 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research

Self-acquired patient images: the promises and the pitfalls.
Authors: Damanpour S, Srivastava D, Nijhawan RI Abstract Self-acquired patient images, also known as selfies, are increasingly utilized in the practice of dermatology; however, research on their utility is somewhat limited. While the implementation of selfies has yet to be universally accepted, their role in triage appears to be especially useful. The potential for reducing office wait times, expediting referrals, and providing dermatologic services to patients with limited access to care is promising. In addition, as technology advances, the number of smartphone applications related to dermatology that ar...
Source: Seminars in Cutaneous Medicine and Surgery - March 12, 2016 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research

Advances in noninvasive imaging of melanoma.
Authors: Menge TD, Pellacani G Abstract Melanoma is the most dangerous type of skin cancer and its incidence has risen sharply in recent decades. Early detection of disease is critical for improving patient outcomes. Any pigmented lesion that is clinically concerning must be removed by biopsy for morphologic investigation on histology. However, biopsies are invasive and can cause significant morbidity, and their accuracy in detecting melanoma may be limited by sampling error. The advent of noninvasive imaging devices has allowed for assessment of intact skin, thereby minimizing the need for biopsy; and the...
Source: Seminars in Cutaneous Medicine and Surgery - March 12, 2016 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research

Computer-assisted diagnosis of melanoma.
Authors: Fuller C, Cellura AP, Hibler BP, Burris K Abstract The computer-assisted diagnosis of melanoma is an exciting area of research where imaging techniques are combined with diagnostic algorithms in an attempt to improve detection and outcomes for patients with skin lesions suspicious for malignancy. Once an image has been acquired, it undergoes a processing pathway which includes preprocessing, enhancement, segmentation, feature extraction, feature selection, change detection, and ultimately classification. Practicality for everyday clinical use remains a vital question. A successful model must obtai...
Source: Seminars in Cutaneous Medicine and Surgery - March 12, 2016 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research

Noninvasive imaging for nonmelanoma skin cancer.
Authors: Giavedoni P, Puig S, Carrera C Abstract The development of noninvasive optical technologies is revolutionizing the diagnosis of skin tumors. Nonmelanoma skin cancer, the most frequent neoplasm, has become an important health and economic issue, and proper management can avoid unnecessary morbidity and mutilating treatment or relapses. Noninvasive treatment modalities and the recently approved systemic therapies for advanced basal cell carcinoma cases make noninvasive monitoring techniques necessary. Current knowledge, applications, and limitations of the tools most clinically implemented, such as ...
Source: Seminars in Cutaneous Medicine and Surgery - March 12, 2016 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research

Radiographic imaging for skin cancer.
Authors: Belkin DA, Wysong A Abstract Radiographic imaging is important for the full evaluation of high-risk cutaneous tumors. The correct modality should be chosen based on tumor subtype and clinical question. Locally advanced tumors may require imaging to evaluate the extent of disease, such as bony involvement, orbital infiltration, or perineural invasion. Tumors at high risk for regional and distant metastasis require imaging to identify local and distant tumor burden. PMID: 26963116 [PubMed - in process] (Source: Seminars in Cutaneous Medicine and Surgery)
Source: Seminars in Cutaneous Medicine and Surgery - March 12, 2016 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research

Introduction.
Authors: Edwards L, Jordan RC PMID: 26814329 [PubMed - in process] (Source: Seminars in Cutaneous Medicine and Surgery)
Source: Seminars in Cutaneous Medicine and Surgery - January 28, 2016 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research

Additional thoughts on the new treatment Kybella.
Authors: Cohen JL, Chen DL, Green JB, Joseph JH Abstract With the recent approval of Kythera Biopharmaceuticals (Westlake Village, California) submental fat injectable treatment Kybella, there comes a lot of excitement-but, also a bit of concern. The idea of having a nonsurgical, nonliposuction treatment for people who have a double chin is certainly exciting. The hope has been that this new treatment will provide opportunities for the many people out there who are focused on the appearance of their submental fullness to have access to a safe. affordable, and reliable treatment.With the approval of this pr...
Source: Seminars in Cutaneous Medicine and Surgery - December 20, 2015 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research