Seminars in Cutaneous Medicine and Surgery 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.The role of molecular testing in the diagnosis of cutaneous soft tissue tumors.
Authors: Cheah AL, Billings SD
Abstract
A number of soft tissue tumors are characterized by recurring genetic abnormalities. The identification of these abnormalities has advanced our understanding of the biology of these tumors and has led to the development of molecular tests that are helpful diagnostically. This review will focus on the application of molecular diagnostic testing in select mesenchymal tumors of the dermis and subcutis.
PMID: 23174492 [PubMed - indexed for MEDLINE] (Source: Seminars in Cutaneous Medicine and Surgery)
Source: Seminars in Cutaneous Medicine and Surgery - November 14, 2014 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research
The role of molecular analysis in cutaneous lymphomas.
Authors: Deonizio JM, Guitart J
Abstract
The purpose of this review is to summarize the most important molecular techniques for the diagnosis of cutaneous lymphomas. When making a diagnosis, we are looking for the solid clinicopathological correlation. Molecular analysis includes immunophenotyping and clonality analysis, and is important for 2 principal reasons: (1) to confirm the diagnosis in cases where the clinical and/or pathological presentations are nondiagnostic, and (2) to further characterize the nature of the lymphoma. More specifically, we are trying to discern whether the lymphoma is primarily ...
Source: Seminars in Cutaneous Medicine and Surgery - November 14, 2014 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research
Polymerase chain reaction-based molecular diagnosis of cutaneous infections in dermatopathology.
Authors: Swick BL
Abstract
Conventional methods, including microscopy, culture, and serologic studies, are a mainstay in the diagnosis of cutaneous infection. However, owing to limitations associated with these techniques, such as low sensitivity for standard microscopy and in the case of culture delay in diagnosis, polymerase chain-reaction based molecular techniques have taken on an expanding role in the diagnosis of infectious processes in dermatopathology. In particular, these assays are a useful adjunct in the diagnosis of cutaneous tuberculosis, atypical mycobacterial infection, leprosy, Lyme disease...
Source: Seminars in Cutaneous Medicine and Surgery - November 14, 2014 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research
Molecular diagnosis of infection-related cancers in dermatopathology.
Authors: Pulitzer M
Abstract
The association between viruses and skin cancer is increasingly recognized in a number of neoplasms, that is, cutaneous squamous cell carcinoma, Kaposi sarcoma, nasopharyngeal carcinoma, and Merkel cell carcinoma, as well as hematolymphoid malignancies such as adult T-cell leukemia/lymphoma and NK/T-cell lymphoma (nasal type) and post-transplant lymphoproliferative disorders. Molecular assays are increasingly used to diagnose and manage these diseases. In this review, molecular features of tumor viruses and related host responses are explored. The tests used to identify such fe...
Source: Seminars in Cutaneous Medicine and Surgery - November 14, 2014 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research
Update on the genetics of androgenetic alopecia, female pattern hair loss, and alopecia areata: implications for molecular diagnostic testing.
Authors: Yazdan P
Abstract
Androgenetic alopecia, female pattern hair loss, and alopecia areata are among the most common forms of nonscarring hair loss encountered in clinical practice. Although the exact pathogenesis of these forms of alopecia remains to be clarified, genetic factors appear to have a significant contribution to their pathogenesis. Current treatment strategies are limited and their effectiveness remains modest at best. This review summarizes the current purported pathogenesis and recent genetic discoveries relating to these forms of alopecia. The role of molecular diagnostic testing is al...
Source: Seminars in Cutaneous Medicine and Surgery - November 14, 2014 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research
Molecular platforms utilized to detect BRAF V600E mutation in melanoma.
Authors: Curry JL, Torres-Cabala CA, Tetzlaff MT, Bowman C, Prieto VG
Abstract
Metastatic melanoma (MM) is a deadly skin disease refractory to standard chemotherapy. Despite numerous clinical and pathological parameters derived to guide patient management, clinical outcomes in melanoma patients remain difficult to predict. There is a critical need to delineate the important biomarkers typical of this disease. These biomarkers will ideally illuminate those key biochemical pathways responsible for the aggressive behavior of melanoma and, in the process, unveil new opportunities for the design of rational the...
Source: Seminars in Cutaneous Medicine and Surgery - November 14, 2014 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research
Molecular diagnostics for ambiguous melanocytic tumors.
Authors: Shahbain H, Cooper C, Gerami P
Abstract
Certain subsets of melanocytic neoplasms are difficult to classify because of conflicting histologic features and the existence of a poorly defined intermediate grade of melanocytic tumors. The integration of molecular diagnostic information with a histologic impression may contribute significantly toward improving classification. This review discusses the development of and advances in molecular techniques, including comparative genomic hybridization and fluorescence in situ hybridization (FISH) as diagnostic and prognostic tools for melanocytic neoplasms. ...
Source: Seminars in Cutaneous Medicine and Surgery - November 14, 2014 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research
Noninvasive procedural dermatology.
Authors: Saedi N, Kaminer M
PMID: 24049922 [PubMed - indexed for MEDLINE] (Source: Seminars in Cutaneous Medicine and Surgery)
Source: Seminars in Cutaneous Medicine and Surgery - November 14, 2014 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research
Treatment of hyperhidrosis with microwave technology.
Authors: Jacob C
Abstract
Hyperhidrosis is the production of sweat above and beyond normal physiological needs, regardless of the ambient temperature, and it affects > 4% of the population. In addition, a poll showed up to 21% of the population is bothered on a daily basis by their amount of underarm sweating. Despite the large number of patients who suffer from hyperhidrosis, there are relatively few effective nonsurgical treatment options. A new, nonsurgical, lasting treatment for axillary hyperhidrosis has now been developed using microwave technology to eliminate sweat glands.
PMID: 24049923...
Source: Seminars in Cutaneous Medicine and Surgery - November 14, 2014 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research
Noninvasive radio frequency for skin tightening and body contouring.
Authors: Weiss RA
Abstract
The medical use of radio frequency (RF) is based on an oscillating electrical current forcing collisions between charged molecules and ions, which are then transformed into heat. RF heating occurs irrespective of chromophore or skin type and is not dependent on selective photothermolysis. RF can be delivered using monopolar, bipolar, and unipolar devices, and each method has theoretical limits of depth penetration. A variant of bipolar delivery is fractional RF delivery. In monopolar configurations, RF will penetrate deeply and return via a grounding electrode. Multiple devices a...
Source: Seminars in Cutaneous Medicine and Surgery - November 14, 2014 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research
Microfocused ultrasound for skin tightening.
Authors: MacGregor JL, Tanzi EL
Abstract
The demand for noninvasive skin tightening procedures is increasing as patients seek safe and effective alternatives to aesthetic surgical procedures of the face, neck, and body. Over the past decade, radiofrequency and infrared laser devices have been popularized owing to their ability to deliver controlled heat to the dermis, stimulate neocollagenesis, and effect modest tissue tightening with minimal recovery. However, these less invasive approaches are historically associated with inferior efficacy so that surgery still remains the treatment of choice to address ...
Source: Seminars in Cutaneous Medicine and Surgery - November 14, 2014 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research
New waves for fat reduction: high-intensity focused ultrasound.
Authors: Saedi N, Kaminer M
Abstract
With the rising demand for body contouring, noninvasive devices for fat reduction have become increasingly popular and have grown dramatically over the past decade. High-intensity focused ultrasound (HIFU) has been used for nearly half a century for the noninvasive treatment of tumors of various organs, but has only recently been evaluated as a method for the selective destruction of adipose tissue. HIFU works by ablating subcutaneous adipose tissue and causing molecular vibrations that increase the temperature of local tissue and induce rapid cell necrosis. Several stu...
Source: Seminars in Cutaneous Medicine and Surgery - November 14, 2014 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research
Cryolipolysis: a historical perspective and current clinical practice.
Authors: Jalian HR, Avram MM
Abstract
Dermatologists have long used cold-based therapeutic approaches for a variety of applications. Based on the differences in chemical composition, it is possible to selectively target certain tissues rich with lipid, while sparing the surrounding tissue predominantly containing water. With historical observations of cold-induced panniculitis suggesting the feasibility of this strategy, cryolipolysis has emerged as a new methodology using controlled cooling to selectively target fat. Both preclinical and clinical studies have established the safety and efficacy of cryolip...
Source: Seminars in Cutaneous Medicine and Surgery - November 14, 2014 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research
Body contouring using 635-nm low level laser therapy.
Authors: Nestor MS, Newburger J, Zarraga MB
Abstract
Noninvasive body contouring has become one of the fastest-growing areas of esthetic medicine. Many patients appear to prefer nonsurgical less-invasive procedures owing to the benefits of fewer side effects and shorter recovery times. Increasingly, 635-nm low-level laser therapy (LLLT) has been used in the treatment of a variety of medical conditions and has been shown to improve wound healing, reduce edema, and relieve acute pain. Within the past decade, LLLT has also emerged as a new modality for noninvasive body contouring. Research has shown that LLLT...
Source: Seminars in Cutaneous Medicine and Surgery - November 14, 2014 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research
Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring.
Authors: Avci P, Gupta A, Sadasivam M, Vecchio D, Pam Z, Pam N, Hamblin MR
Abstract
Low-level laser (light) therapy (LLLT) is a fast-growing technology used to treat a multitude of conditions that require stimulation of healing, relief of pain and inflammation, and restoration of function. Although skin is naturally exposed to light more than any other organ, it still responds well to red and near-infrared wavelengths. The photons are absorbed by mitochondrial chromophores in skin cells. Consequently, electron transport, adenosine triphosphate nitric oxide release, blood flow, reactive oxygen species incre...
Source: Seminars in Cutaneous Medicine and Surgery - November 14, 2014 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research
