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Psychosocial Issues in Acne Management: Disease Burden, Treatment Adherence, and Patient Support.
Authors: Zaenglein AL
Abstract
Physical and emotional scarring are equally important burdens of acne vulgaris in patients of any age. Effective therapeutic regimens are readily available, and the consistent and correct use of these medications results in effective disease management, reduced risk for scarring, as well as improvement in various factors that affect quality of life. Nevertheless, adherence to treatment recommendations generally is poor. Clinicians can help improve adherence with a variety of strategies, including counseling, education, and choosing treatment options that are most consistent w...
Source: Seminars in Cutaneous Medicine and Surgery - December 5, 2015 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research
Introduction.
Authors: Kerdel FA
PMID: 26624853 [PubMed - as supplied by publisher] (Source: Seminars in Cutaneous Medicine and Surgery)
Source: Seminars in Cutaneous Medicine and Surgery - December 5, 2015 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research
Introduction.
Authors: Pariser DM, Zachary CB
PMID: 26624885 [PubMed - as supplied by publisher] (Source: Seminars in Cutaneous Medicine and Surgery)
Source: Seminars in Cutaneous Medicine and Surgery - December 5, 2015 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research
Identifying and Managing Complications and Comorbidities in Patients With Psoriasis.
Authors: Duffin KC
Abstract
The common comorbidities of cutaneous psoriasis include psoriatic arthritis (PsA), Crohn's disease, uveitis, and depression. In addition, cardiovascular disease risk factors (including metabolic syndrome) are seen more frequently among patients with psoriasis, and strong epidemiologic evidence has demonstrated that psoriasis is independently associated with myocardial infarction. Because these comorbid conditions and other medical complications adversely affect morbidity and mortality in patients with psoriasis, dermatologists can play an important role in promptly identifying a...
Source: Seminars in Cutaneous Medicine and Surgery - December 5, 2015 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research
Efficacy and Safety of Onychomycosis Treatments: An Evidence-Based Overview.
Authors: Pariser DM
Abstract
Three systemic agents commonly are used for the treatment of onychomycosis. Until the introduction of ciclopirox in 1999, these were the only FDA-approved therapeutic options for managing these infections. With the recent approval of two new topical antifungal agents-efinaconazole in the azole class, and tavaborole, a unique boron-containing medication- clinicians and patients have an improved roster of medications for managing onychomycosis. Semin Cutan Med Surg 34(supp3):S46-S50 © 2015 published by Frontline Medical Communications.
PMID: 26624988 [PubMed - as supplie...
Source: Seminars in Cutaneous Medicine and Surgery - December 5, 2015 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research
Pharmacologic Treatment Options in Mild, Moderate, and Severe Acne Vulgaris.
Authors: Baldwin HE
Abstract
Most patients with acne have a disease that responds to acute treatment and can be controlled long term with a maintenance regimen of topical therapy. It is the minority of patients-generally, but not exclusively-the most severely affected, who respond poorly to acute therapy and require continued systemic therapy. The goals of therapy are resolution of visible lesions, prevention of new lesions, avoidance of scarring, and improvement of patient quality of life. Treatment choices are made on the basis of lesion type, number, and size, with consideration given to the presence of...
Source: Seminars in Cutaneous Medicine and Surgery - December 5, 2015 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research
Screening and Monitoring Before and During Systemic Therapy: Recommendations for Patients With Psoriasis.
Authors: Duffin KC
Abstract
When patients with psoriasis are candidates for systemic therapy, the list of appropriate agents for each patient should be derived from careful patient and family history and selected laboratory screening protocols so that the potential risks associated with treatment can be minimized. Once a therapeutic choice is made, monitoring strategies also are necessary for early identification and intervention of adverse events that may arise. In addition to appropriate screening and monitoring protocols, communication between patient and clinician is essential to enhance the benefits o...
Source: Seminars in Cutaneous Medicine and Surgery - December 5, 2015 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research
Isotretinoin: Mechanism of Action and Patient Selection.
Authors: Webster GF
Abstract
Oral isotretinoin is a highly effective treatment for appropriately selected patients with acne. This medication is the only treatment that targets all four of the identified factors underlying acne pathogenesis. In addition to the approved indication of resistant nodular scarring acne, clinical studies and experience have shown that other categories of patients benefit from isotretinoin therapy, including those with resistant scarring papular acne, those with resistant acne that interferes with normal living, those who have severe acne-related psychological sequelae, and those...
Source: Seminars in Cutaneous Medicine and Surgery - December 5, 2015 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research
TNF Inhibitors in Psoriasis: A Review.
Authors: Kerdel FA
Abstract
Adalimumab, etanercept, and infliximab are tumor necrosis factor (TNF) inhibitors that are currently approved by the US Food and Drug Administration for the treatment of moderate to severe psoriasis. The availability of these biologic agents established a new benchmark in the treatment of psoriasis that requires systemic therapy to control psoriasis signs and symptoms. Although a number of other biologic agents and small molecules have been approved recently, TNF inhibitors remain a cornerstone of psoriasis therapy. Semin Cutan Med Surg 34(supp2):S37-S39 © 2015 published by Fro...
Source: Seminars in Cutaneous Medicine and Surgery - December 5, 2015 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research
Introduction.
Authors: Baldwin HE
PMID: 26629891 [PubMed - as supplied by publisher] (Source: Seminars in Cutaneous Medicine and Surgery)
Source: Seminars in Cutaneous Medicine and Surgery - December 5, 2015 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research
A noninvasive approach to off-face skin laxity and tightening: a review of the literature.
Authors: Jerdan K, Fabi S
Abstract
Off-face skin scales tailored to each anatomical site can measure laxity and tightening of the neck, chest, arms, hands, abdomen, buttocks, and medial thighs. Although surgery may be indicated for major weight loss patients, other noninvasive modalities may be considered including: CO2 laser, bipolar radiofrequency, monopolar radiofrequency, microfocused ultrasound, and combination therapies. We provide a review of the literature for each modality and relevance to the off-face anatomical sites.
PMID: 26566567 [PubMed - as supplied by publisher] (Source: Seminars i...
Source: Seminars in Cutaneous Medicine and Surgery - November 14, 2015 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research
Noninvasive body contouring: cryolipolysis and ultrasound.
Authors: Ortiz AE, Avram MM
Abstract
Over the past 5 years, there has been a paradigm shift in the treatment of fat. The clear trend is toward noninvasive fat removal technologies over more traditional forms of fat removal such as liposuction. While these devices do not yet approach the results seen with liposuction, noninvasive treatments are gaining popularity due to their ability to safely and effectively reduce fat with little downtime and typically no need for anesthesia. The optimal candidate is relatively fit with localized areas of adiposity, rather than an obese patient. It is important to note th...
Source: Seminars in Cutaneous Medicine and Surgery - November 14, 2015 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research
Injectable agents affecting subcutaneous fats.
Authors: Chen DL, Cohen JL, Green JB
Abstract
Mesotherapy is an intradermal or subcutaneous injection of therapeutic agents to induce local effects, and was pioneered in Europe during the 1950s. For the past 2 decades, there has been significant interest in the use of mesotherapy for minimally invasive local fat contouring. Based on the theorized lipolytic effects of the agent phosphatidylcholine, initial attempts involved its injection into subcutaneous tissue. With further studies, however, it became apparent that the activity attributed to phosphatidylcholine mesotherapy was due to the adipolytic effect...
Source: Seminars in Cutaneous Medicine and Surgery - November 14, 2015 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research
Therapeutic approaches to cellulite.
Authors: Green JB, Cohen JL, Kaufman J, Metelitsa AI, Kaminer MS
Abstract
Cellulite is a condition that affects the vast majority of women. Although it is of no danger to one's overall health, cellulite can be psychosocially debilitating. Consequently, much research has been devoted to understanding cellulite and its etiopathogenesis. With additional insights into the underlying causes of its clinical presentation, therapeutic modalities have been developed that offer hope to cellulite sufferers. This review examines evidence for topical treatments, noninvasive energy-based devices, and recently developed ...
Source: Seminars in Cutaneous Medicine and Surgery - November 14, 2015 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research
Hand rejuvenation.
Authors: Riyaz FR, Ozog D
Abstract
Aging of the hands results from both natural processes and chronic ultraviolet light exposure. Together, these cause textural and pigmentary changes, excess skin laxity, rhytides, and soft tissue atrophy that presents as prominent bones and tendons with easily visible veins. Many options are available for the reversal of these changes. Photoaging can be improved with chemical peels and light-based treatments (such as Q-switched lasers), resurfacing lasers, intense pulsed light, and photodynamic therapy. Soft tissue atrophy can be corrected with autologous fat, nonanimal s...
Source: Seminars in Cutaneous Medicine and Surgery - November 14, 2015 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research