Announcement
(Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - September 27, 2017 Category: Allergy & Immunology Tags: Announcement Source Type: research
Issue Information
(Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - September 27, 2017 Category: Allergy & Immunology Tags: Issue Information Source Type: research
The dual role of Treg in cancer
This article is protected by copyright. All rights reserved. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - September 23, 2017 Category: Allergy & Immunology Authors: Magdalena Frydrychowicz, Maciej Boruczkowski, Agata Kolecka ‐Bednarczyk, Grzegorz Dworacki Tags: Review Source Type: research
The Prognostic Significance of Soluble Programmed Death Ligand 1 Expression in Cancers: A Systematic Review and Meta ‐analysis
Abstract
The differential expression of soluble programmed death ligand 1 (sPD‐L1) has been found in some cancers; however, the correlation between sPD‐L1 expression and prognosis value in tumour is still unclear. Here, we conducted a meta‐analysis and systematic review to assess the prognostic value of sPD‐L1 in patients with cancer. Eligible studies were searched for in the databases including PubMed, Web of Science, ScienceDirect and Wiley Online Library database. The pooled hazard ratios (HRs) with a 95% confidence interval (95%CI) were calculated to assess the prognostic significance of sPD‐L1 in human cance...
Source: Scandinavian Journal of Immunology - September 19, 2017 Category: Allergy & Immunology Authors: Y. Ding, C. Sun, J. Li, L. Hu, M. Li, J. Liu, L. Pu, S. Xiong Tags: Review Source Type: research
Increased expression of programmed cell death ‐1 in regulatory T‐cells of patients with severe sepsis and septic shock: an observational clinical study
This article is protected by copyright. All rights reserved. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - September 9, 2017 Category: Allergy & Immunology Authors: Qiang Liu, Le An, Zhijiang Qi, Yongzhen Zhao, Chunsheng Li Tags: Regular Article Source Type: research
Dysregulation of Circulating Tfr/Tfh Ratio in Primary biliary cholangitis
This article is protected by copyright. All rights reserved. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - September 1, 2017 Category: Allergy & Immunology Authors: Jiajia Zheng, Tiancheng Wang, Li Zhang, Liyan Cui Tags: Regular Article Source Type: research
Composition and variation analysis of the TCR β‐chain CDR3 repertoire in neonatal sepsis
This article is protected by copyright. All rights reserved. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - September 1, 2017 Category: Allergy & Immunology Authors: Jinqiao Sun, Bijun Sun, Yanyan Gao, Fusheng He, Lin Yang, Mingbang Wang, Wenhao Zhou Tags: Regular Article Source Type: research
TLR ‐induced SMPD3 defects enhance inflammatory response of B cell and macrophage in the pathogenesis of SLE
This article is protected by copyright. All rights reserved. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - September 1, 2017 Category: Allergy & Immunology Authors: Fei Liu, Xiaojing Li, Huimin Yue, Jianjian Ji, Ming You, Liang Ding, Hongye Fan, Yayi Hou Tags: Regular Article Source Type: research
Mesenchymal stem cells overexpressing interleukin ‐35 propagate immunosuppressive effects in mice
ConclusionIL‐35‐transduced Ad‐MSCs in vivo can enhance proliferation of CD4+ CD25+ Treg cells and suppress the function of effector T cells such as T helper (Th) 1, Th2 and Th17 cells, and may reduce the development of allograft rejection. Our data suggest that transduced Ad‐MSCs overexpressing IL‐35 may provide a useful approach for basic research on cell‐based immunotolerance therapy for inducing transplantation tolerance.This article is protected by copyright. All rights reserved. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - September 1, 2017 Category: Allergy & Immunology Authors: Hao Guo, Na Zhao, Haopeng Gao, Xianghui He Tags: Regular Article Source Type: research
Systemic Treatment with a miR ‐146a Mimic Suppresses Endotoxin Sensitivity and Partially Protects Mice from the Progression of Acute Graft‐versus‐Host Disease
This article is protected by copyright. All rights reserved. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - August 30, 2017 Category: Allergy & Immunology Authors: John G. Gartner, Melanie M. Durston, Stephanie A. Booth, Cynthia A. Ellison Tags: Regular Article Source Type: research
LPS ‐Induced ex vivo Cytokine Production is Not Augmented in Patients with Von Hippel‐Lindau Disease
(Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - August 21, 2017 Category: Allergy & Immunology Authors: D. Kiers, H. J. L. M. Timmers, J. Gerretsen, P. Pickkers, M. Kox Tags: Letter to the Editor Source Type: research
Skewed Invariant Natural Killer T (iNKT) Cells, Impaired iNKT:B Cell Help and Decreased SAP Expression in Blood Lymphocytes from Patients with Common Variable Immunodeficiency
Abstract
Common variable immunodeficiency (CVID) is a syndrome with predominantly defective B cell function. However, abnormalities in the number and function of other lymphocyte subpopulations in peripheral blood (PB) have been described in most patients. We have analysed the distribution of iNKT cell subpopulations in the PB of CVID patients and the ability of these cells to provide in vitro cognate B cell help. The total of iNKT cells was reduced in the PB of CVID patients, especially CD4+, CD4‐/CD8‐ and CCR5+/CXCR3+. These findings were associated with an enrichment of memory‐like and a tendency towards a reduct...
Source: Scandinavian Journal of Immunology - August 21, 2017 Category: Allergy & Immunology Authors: L. V. Erazo ‐Borrás, J. A. Álvarez‐Álvarez, C. A. Perez‐Romero, J. C. Orrego‐Arango, J. L. Franco‐Restrepo, C. M. Trujillo‐Vargas Tags: Human Immunology Source Type: research
Assays for Infliximab Drug Levels and Antibodies: A Matter of Scales and Categories
Abstract
Immunogenicity is a frequent cause of secondary non‐response to tumour necrosis factor (TNF) inhibitors. Drug level measurement and detection of antidrug antibodies have been shown to be cost effective and clinically relevant, and a large number of assays are available for these purposes. It is, however, difficult to compare assays and translate results into clinical meaningful information due to different methodological approaches and a lack of assay standardization. We have analysed infliximab drug levels and antidrug antibodies in 107 patient samples using enzyme‐linked immunoassays (ELISA), immunofluoromet...
Source: Scandinavian Journal of Immunology - August 21, 2017 Category: Allergy & Immunology Authors: L. I. Bader, S. M. Solberg, S. H. Kaada, N. Bolstad, D. J. Warren, S. Gavasso, C. G. Gjesdal, C. A. Vedeler Tags: Human Immunology Source Type: research
The Abl ‐1 Kinase is Dispensable for NK Cell Inhibitory Signalling and is not Involved in Murine NK Cell Education
Abstract
Natural killer (NK) cell responsiveness in the mouse is determined in an education process guided by inhibitory Ly49 and NKG2A receptors binding to MHC class I molecules. It has been proposed that inhibitory signalling in human NK cells involves Abl‐1 (c‐Abl)‐mediated phosphorylation of Crk, lowering NK cell function via disruption of a signalling complex including C3G and c‐Cbl, suggesting that NK cell education might involve c‐Abl. Mice deficient in c‐Abl expression specifically in murine NK cells displayed normal inhibitory and activating receptor repertoires. Furthermore, c‐Abl‐deficient NK cel...
Source: Scandinavian Journal of Immunology - August 21, 2017 Category: Allergy & Immunology Authors: S. Ganesan, T.T. Luu, B. J. Chambers, S. Meinke, P. Brodin, E. Vivier, D. M. Wetzel, A.J. Koleske, N. Kadri, P. H öglund Tags: Experimental Immunology Source Type: research
Giving Context to Non ‐self‐marker Theories of Immune Responsiveness
Abstract
In 2001, long ago by modern standards, Matzinger changed the emphasis of her Danger theory from one that downplayed the self‐non‐self discrimination to one that concerned itself with the regulation of effector class. This gave her theory a measure of validity that the other non‐self‐marker theorists have yet to confront. However, precision and clarity are still lacking. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - August 21, 2017 Category: Allergy & Immunology Authors: M. Cohn Tags: Discussion Forum Source Type: research
