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Scandinavian Journal of Immunology,Volume 87, Issue 3, March 2018. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - January 24, 2018 Category: Allergy & Immunology Source Type: research
Somatic diversification of the B cell repertoire requires two cell subsets
Abstract
Evolution found itself in a Catch‐22 situation when selecting for the somatically derived paratopic repertoire of the humoral immune system. The B cell BCR repertoire can only be somatically diversified from a substrate of paratopes that is encoded in the germline. In order for the cells expressing that substrate to also be a target of germline selection, their BCRs must, independently, be of selective value by being expressed in a functionally important way in each individual. A somatically derived repertoire scrambles this substrate so that its specificities are lost, making it unselectable in the germline. C...
Source: Scandinavian Journal of Immunology - January 22, 2018 Category: Allergy & Immunology Authors: M. Cohn Tags: DISCUSSION FORUM Source Type: research
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Scandinavian Journal of Immunology,Volume 87, Issue 3, March 2018. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - January 16, 2018 Category: Allergy & Immunology Source Type: research
Plasma levels of innate immune mediators are associated with liver fibrosis in low parasite burden Schistosoma mansoni ‐infected individuals
This article is protected by copyright. All rights reserved. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - January 1, 2018 Category: Allergy & Immunology Authors: Jailza Lima Rodrigues Oliveira, Mauro Martins Teixeira, Jos é Roberto Lambertucci, Carlos Maurício de Figueiredo Antunes, Mariângela Carneiro, Deborah Negrão‐Corrêa Tags: Regular Article Source Type: research
Time ‐dependent distinct roles of Toll‐like receptor 4 in a house‐dust‐mite‐induced asthma mouse model
This article is protected by copyright. All rights reserved. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - January 1, 2018 Category: Allergy & Immunology Authors: Takashi Ishii, Yuichi Niikura, Keigo Kurata, Masashi Muroi, Ken ‐ichi Tanamoto, Takahide Nagase, Masahiro Sakaguchi, Naomi Yamashita Tags: Regular Article Source Type: research
Somatic diversification of the B ‐cell repertoire requires two cell subsets
This article is protected by copyright. All rights reserved. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - January 1, 2018 Category: Allergy & Immunology Authors: Melvin Cohn Tags: Regular Article Source Type: research
Comment on: Phenotypic Prenatal Diagnosis of Chronic Granulomatous Disease: A Useful Tool in the Absence of Molecular Diagnosis
(Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - December 28, 2017 Category: Allergy & Immunology Authors: P. E. Newburger Tags: Letter to the Editor Source Type: research
Positive Kappa ‐Deleting Recombination Excision Circles (KREC) Newborn Screening in a Neonate With Intrauterine Exposure to Rituximab
(Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - December 28, 2017 Category: Allergy & Immunology Authors: R. Kr üger, S. Borte, K. Weizsäcker, V. Wahn, C. Feiterna‐Sperling Tags: Letter to the Editor Source Type: research
Editorial —New Editor‐in‐Chief from 2018 for Scandinavian Journal of Immunology
(Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - December 28, 2017 Category: Allergy & Immunology Authors: R. Jonsson, H. ‐G. Ljunggren Tags: Editorial Source Type: research
Issue Information
(Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - December 28, 2017 Category: Allergy & Immunology Tags: Issue Information Source Type: research
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Scandinavian Journal of Immunology,Volume 87, Issue 3, March 2018. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - December 27, 2017 Category: Allergy & Immunology Source Type: research
Signalling Profiles of Blood Leucocytes in Sepsis and in Acute Pancreatitis in Relation to Disease Severity
Abstract
Intracellular signalling in blood leucocytes shows multiple aberrations in acute pancreatitis (AP) complicated by organ dysfunction (OD). We studied whether the aberrations associate with severity of AP and occur in sepsis complicated by OD. The study comprises 14 sepsis patients (11 with shock), 18 AP patients (nine mild; six moderately severe; three severe) and 28 healthy volunteers. Within 48 h after admission to hospital, phosphorylation of nuclear factor‐ĸB (NF‐ĸB), signal transducers and activators of transcription (STATs) 1,3, and extracellular signal‐regulated kinases 1/2 were measured from stimul...
Source: Scandinavian Journal of Immunology - December 12, 2017 Category: Allergy & Immunology Authors: K. Kuuliala, A. K. Penttil ä, K.‐M. Kaukonen, H. Mustonen, A. Kuuliala, J. Oiva, M. Hämäläinen, E. Moilanen, V. Pettilä, P. Puolakkainen, L. Kylänpää, H. Repo Tags: Human Immunology Source Type: research
‘25‐Hydroxyvitamin D, Autoantigenic and Total Antibody Concentrations: Results from a Danish Case–control Study of Newly Diagnosed Patients with Childhood Type 1 Diabetes and their Healthy Siblings’
Abstract
B cells have recently entered the stage as an important accessory player in type 1 diabetes (T1D) etiopathogenesis. Experimental studies suggest regulatory functions of vitamin D on B cells. However, only a few human studies, with considerable methodological limitations, have been conducted within this field. Our objective was to investigate whether higher 25‐hydroxyvitamin D (25(OH)D) concentrations were inversely associated with β‐cell autoantigens glutamic acid decarboxylase (isoform 65) (GADA) and insulinoma‐associated antigen‐2A (IA‐2A). Further, we also wanted to examine the relationship between 2...
Source: Scandinavian Journal of Immunology - December 12, 2017 Category: Allergy & Immunology Authors: S. U. Thorsen, C. B. Pipper, J. Johannesen, H. B. Mortensen, F. Pociot, J. Svensson Tags: Human Immunology Source Type: research
IL ‐23 Activated γδ T Cells Affect Th17 Cells and Regulatory T Cells by Secreting IL‐21 in Children with Primary Nephrotic Syndrome
This study (1) analysed the percentage of γδ T cells, γδ T cell subsets, Th17 cells and regulatory T cells (Treg cells) and (2) determined the role of IL‐23 in primary nephrotic syndrome (PNS) patients with active disease and in remission. Eighty‐four patients with PNS and 51 healthy age‐matched controls were included in this study. The percentage of γδ T cells, γδ T cell subsets, Th17 cells and Treg cells in peripheral blood mononuclear cells (PBMCs) were analysed by fluorescence‐activated cell sorting. PMBCs from PNS patients with active disease were cultured in the presence of IL‐23, IL‐23 and an IL...
Source: Scandinavian Journal of Immunology - December 7, 2017 Category: Allergy & Immunology Authors: L. Zhang, J. Yan, B. Yang, G. Zhang, M. Wang, S. Dong, W. Liu, H. Yang, Q. Li Tags: Human Immunology Source Type: research
