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Scandinavian Journal of Immunology,Volume 87, Issue 3, March 2018. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - February 27, 2018 Category: Allergy & Immunology Source Type: research
Soluble MHC class II ‐driven therapy for a systemic lupus erythematosus murine experimental in vitro and in vivo model
Abstract
Taking into consideration the multiparametric nature of systemic lupus erythematosus (SLE), the severity and variability of symptoms and the lack of effective therapeutic approaches, this study took advantage of the recently described role of soluble major histocompatibility complex class II (sMHCII) molecules in maintaining tolerance to the organism and attempted to apply sMHCII proteins as a treatment to murine SLE experimental models in vitro as well as in vivo. After breaking tolerance to DNA in vitro, which was accompanied by development of specific anti‐dsDNA antibodies, syngeneic or allogeneic sMHCII m...
Source: Scandinavian Journal of Immunology - February 27, 2018 Category: Allergy & Immunology Authors: K. Bakela, M. Dimakopoulou, P. Batsou, N. Manidakis, I. Athanassakis Tags: EXPERIMENTAL IMMUNOLOGY Source Type: research
T ‐cell cross‐reactivity may explain the large variation in how cancer patients respond to checkpoint inhibitors
Abstract
The therapeutic use of the immune system to specifically attack tumours has been a long‐standing vision among tumour immunologists. Recently, the use of checkpoint inhibitors to turn‐off immunosuppressive signals has proven to be effective in enhancing T‐cell reactivity against patient‐specific neoantigens, resulting from somatic mutations. Several of the identified T‐cell epitopes share similarity with common bacterial and viral antigens, suggesting the involvement of pre‐existing microbial cross‐reactive T cells in rapid and durable tumour regression seen in some patients. This notion of T‐cell c...
Source: Scandinavian Journal of Immunology - February 27, 2018 Category: Allergy & Immunology Authors: Mouldy Sioud Tags: REVIEW ARTICLE Source Type: research
Issue Information
(Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - February 27, 2018 Category: Allergy & Immunology Tags: Issue Information Source Type: research
Evolution from one autoimmune disorder to another.Epitope spreading?
This article is protected by copyright. All rights reserved. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - February 27, 2018 Category: Allergy & Immunology Authors: Panagiota Karagianni, Evangelia Zampeli, Haralampos M. Moutsopoulos Tags: Letter to the Editor Source Type: research
Endogenous protein and enzyme fragments induce immunoglobulin E ‐independent activation of mast cells via a GPCR, MRGPRX2
This article is protected by copyright. All rights reserved. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - February 27, 2018 Category: Allergy & Immunology Authors: Kazuhiko Tatemoto, Yuko Nozaki, Ryoko Tsuda, Shinobu Kaneko, Keiko Tomura, Masahiro Furuno, Hiroyuki Ogasawara, Koji Edamura, Hideo Takagi, Hiroyuki Iwamura, Masato Noguchi, Takayuki Naito Tags: Regular Article Source Type: research
Evaluation of Oxidative Stress and Antioxidant Status: Correlation with the Severity of Sepsis
This study suggests that imbalance between oxidant and antioxidant play key role in the severity of sepsis.
This article is protected by copyright. All rights reserved. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - February 27, 2018 Category: Allergy & Immunology Authors: Sanni Kumar, Ena Gupta, Sanket Kaushik, Vijay Kumar Srivastava, Sudhir Kumar Mehta, Anupam Jyoti Tags: Regular Article Source Type: research
Immune activation by nucleic acids: A role in pregnancy complications
Scandinavian Journal of Immunology,Volume 87, Issue 4, April 2018. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - February 26, 2018 Category: Allergy & Immunology Source Type: research
Expression of interleukin ‐17 in primary Sjögren's syndrome and the correlation with disease severity: A systematic review and meta‐analysis
Scandinavian Journal of Immunology,Volume 87, Issue 4, April 2018. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - February 24, 2018 Category: Allergy & Immunology Source Type: research
Expression of Interleukin ‐17 in Primary Sjögren's Syndrome and the Correlation with Disease Severity: A Systematic Review and Meta‐Analysis
In conclusion, the expression of IL‐17 is obviously increased in pSS patients, especially among those without immunosuppressive treatment. In addition, IL‐17 level correlates with the disease severity of pSS. These findings demonstrate the significance of IL‐17 overexpression in pSS patients, and may provide insights for the development of therapeutic interventions targeting IL‐17 for pSS.
This article is protected by copyright. All rights reserved. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - February 24, 2018 Category: Allergy & Immunology Authors: Li ‐Wei Zhang, Pei‐Ru Zhou, Pan Wei, Xin Cong, Li‐Ling Wu, Hong Hua Tags: Regular Manuscript Source Type: research
Alternative Th17 and CD4+CD25+FoxP3+ cell frequencies increase and correlate with worse cardiac function in Chagas cardiomyopathy
Scandinavian Journal of Immunology,Volume 87, Issue 4, April 2018. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - February 23, 2018 Category: Allergy & Immunology Source Type: research
Endothelial extracellular vesicles modulate the macrophage phenotype: Potential implications in atherosclerosis
Scandinavian Journal of Immunology,Volume 87, Issue 4, April 2018. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - February 21, 2018 Category: Allergy & Immunology Source Type: research
Interleukin ‐17A participates in podocyte injury by inducing IL‐1β secretion through ROS‐NLRP3 inflammasome‐caspase‐1 pathway
Scandinavian Journal of Immunology,Volume 87, Issue 4, April 2018. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - February 15, 2018 Category: Allergy & Immunology Source Type: research
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Scandinavian Journal of Immunology,Volume 87, Issue 3, March 2018. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - February 11, 2018 Category: Allergy & Immunology Source Type: research
