Computational Prediction of Usutu Virus E Protein B Cell and T Cell Epitopes for Potential Vaccine Development
In this study, we have used computational tools to predict potential B cell and T cell epitopes of USUV envelope (E) protein. We found that amino acids between positions 68 and 84 could be a potential B cell epitope, while amino acids between positions 53 and 69 could be a potential major histocompatibility complex (MHC) class I‐ and class II‐restricted T cell epitope. By homology 3D modeling of USUV E protein, we found that the predicted B cell epitope was predominantly located in the coil region, while T cell epitope was located in the beta‐strand region of the E protein. Additionally, the potential MHC class I T c...
Source: Scandinavian Journal of Immunology - April 24, 2017 Category: Allergy & Immunology Authors: N. Palanisamy, J. Lennerstrand Tags: Experimental Immunology Source Type: research
A Commentary on a Workshop ‘To Reveal the Foundational Concepts of Immune Regulation’ (i.e. Tolerance)
Abstract
A summary of the workshop with its laudatory goal ‘to reveal the foundational concepts in immunology’ was recently published in SJI with an invitation to outsiders to comment. In the end, a foundational concept is one upon which we can all agree. This requires debate and meaningful experimentation. The goal of this commentary is to provide some of that. Most of immunology is description of an observation (i.e. a fact). However, what ties all the facts together as a discipline is theory or conceptualization that gives a general context to observation and predicts the next step. This is what is meant by ‘found...
Source: Scandinavian Journal of Immunology - April 24, 2017 Category: Allergy & Immunology Authors: M. Cohn Tags: Discussion Forum Source Type: research
Announcement
(Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - April 24, 2017 Category: Allergy & Immunology Tags: Announcement Source Type: research
Issue Information
(Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - April 24, 2017 Category: Allergy & Immunology Tags: Issue Information Source Type: research
Distinct Roles of Th17 and Th1 Cells in Inflammatory Responses Associated with the Presentation of Paucibacillary Leprosy and Leprosy Reactions Th17 Immune Response in Leprosy
This article is protected by copyright. All rights reserved. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - April 20, 2017 Category: Allergy & Immunology Authors: M árcio Bezerrra Santos, Daniela Teles Oliveira, Rodrigo Anselmo Cazzaniga, Crisuelle Santana Varjão, Priscila Lima dos Santos, Micheli L. B. Santos, Cristiane Bane Correia, Daniela R. Faria, Marise do Vale Simon, João Santana Silva, Walderez O. Dutra, Tags: Regular Article Source Type: research
Subunit vaccines consisting of antigens from dormant and replicating bacteria show promising therapeutic effect against Mycobacterium bovis BCG latent infection
This article is protected by copyright. All rights reserved. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - April 20, 2017 Category: Allergy & Immunology Authors: Fei Li, Hongfei Kang, Jingjing Li, Dengcai Zhang, Ying Zhang, Arthur M. Dannenberg, Xun Liu, Hongxia Niu, Lan Ma, Ruitian Tang, Xue Han, Chao Gan, Xingming Ma, Jiying Tan, Bingdong Zhu Tags: Regular Article Source Type: research
A non ‐pathogenic recombinant Leishmania expressing Lipophosphoglycan 3 against experimental infection with Leishmania infantum
This article is protected by copyright. All rights reserved. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - April 20, 2017 Category: Allergy & Immunology Authors: Leila Pirdel, Safar Farajnia Tags: Regular Article Source Type: research
Melanocortin 2, 3 and 4 receptor gene expressions are downregulated in CD8+ T cytotoxic lymphocytes and CD19+ B lymphocytes in rheumatoid arthritis responding to TNF α inhibition
This article is protected by copyright. All rights reserved. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - April 20, 2017 Category: Allergy & Immunology Authors: Marlene Andersen, Ivan Nagaev, Michael Kruse Meyer, Olga Nagaeva, Jarl Wikberg, Lucia Mincheva ‐Nilsson, Grethe Neumann Andersen Tags: Regular Article Source Type: research
TLR stimulated eosinophils mediate recruitment and activation of NK cells in vivo
This article is protected by copyright. All rights reserved. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - April 1, 2017 Category: Allergy & Immunology Authors: Shaunagh M. O'Flaherty, Kripitch Sutummaporn, Walina L. H äggtoft, Amy P. Worrall, Marzia Rizzo, Viorica Braniste, Petter Höglund, Nadir Kadri, Benedict J. Chambers Tags: Regular Article Source Type: research
Immune balance in Hepatitis B Infection: Present and Future Therapies
This article is protected by copyright. All rights reserved. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - April 1, 2017 Category: Allergy & Immunology Authors: Ashish Kumar Vyas, Ankur Jindal, Syed Hissar, Gayatri Ramakrishna, Nirupama Trehanpati Tags: Review Source Type: research
Dendritic cells from rheumatoid arthritis patient peripheral blood induce Th17 cell differentiation via miR ‐363/Integrin αv/TGF‐β axis
ConclusionThese data demonstrated that DCs induced Th17 cell differentiation through miR‐363/Integrin αv/TGF‐β pathway in RA patients.This article is protected by copyright. All rights reserved. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - April 1, 2017 Category: Allergy & Immunology Authors: Feng Pan, Haiyan Xiang, Juzhen Yan, Liquan Hong, Lahong Zhang, Yuhua Liu, Xiao Feng, Chengsong Cai Tags: Regular Article Source Type: research
Identification and characterization of a nationwide Danish adult common variable immunodeficiency cohort
This study emphasizes the need for improved diagnostic criteria and more awareness of CVID as a differential diagnosis. Diagnosis and management of CVID patients is a challenge requiring specialists with experience in the field of PID.
This article is protected by copyright. All rights reserved. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - April 1, 2017 Category: Allergy & Immunology Authors: Lena Westh, Trine Hyrup Mogensen, Lars Skov Dalgaard, Jens Magnus Bernth Jensen, Terese Katzenstein, Ann ‐Brit Eg Hansen, Olav Ditlevsen Larsen, Steen Terpling, Thyge Lynghøj Nielsen, Carsten Schade Larsen Tags: Regular Article Source Type: research
Factors Influencing Serum Concentrations of Immunoglobulin D in the Adult Population: An Observational Study in Spain
In conclusion, serum IgD concentrations in adults show a wide variation in the population and may be influenced by common factors, particularly age and smoking habit. These factors should be taken into account when defining reference ranges for serum IgD concentrations. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - March 30, 2017 Category: Allergy & Immunology Authors: I. Carballo, N. Rabu ñal, L. Alvela, L.‐F. Pérez, C. Vidal, M. Alonso, B. Sopeña, F. Gude, A. Gonzalez‐Quintela Tags: Human Immunology Source Type: research
The Inflammation Induced by Lipopolysaccharide can be Mitigated by Short ‐chain Fatty Acid, Butyrate, through Upregulation of IL‐10 in Septic Shock
In conclusion, SCFA butyrate significantly attenuated the inflammation against sepsis through upregulation of anti‐inflammatory IL‐10. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - March 30, 2017 Category: Allergy & Immunology Authors: F. Wang, J. Liu, T. Weng, K. Shen, Z. Chen, Y. Yu, Q. Huang, G. Wang, Z. Liu, S. Jin Tags: Experimental Immunology Source Type: research
Announcement
(Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - March 30, 2017 Category: Allergy & Immunology Tags: Announcement Source Type: research
