Mesenchymal stem cells overexpressing interleukin ‐35 propagate immunosuppressive effects in mice

ConclusionIL‐35‐transduced Ad‐MSCs in vivo can enhance proliferation of CD4+ CD25+ Treg cells and suppress the function of effector T cells such as T helper (Th) 1, Th2 and Th17 cells, and may reduce the development of allograft rejection. Our data suggest that transduced Ad‐MSCs overexpressing IL‐35 may provide a useful approach for basic research on cell‐based immunotolerance therapy for inducing transplantation tolerance.This article is protected by copyright. All rights reserved.
Source: Scandinavian Journal of Immunology - Category: Allergy & Immunology Authors: Tags: Regular Article Source Type: research