Novel Application of Aptamer Proteomic Analysis in Cystic Fibrosis Bronchoalveolar Lavage Fluid
Conclusions and clinical relevance: Proteomic analysis of the CF airway demonstrates a complex environment of proteins and pathways. This work provides evidence that aptamer ‐based proteomics can differentiate between groups and can determine endotypes within CF.This article is protected by copyright. All rights reserved (Source: Proteomics. Clinical Applications)
Source: Proteomics. Clinical Applications - November 15, 2018 Category: Biochemistry Authors: Emily M. DeBoer,
Brandie D. Wagner,
Jonathan Popler,
J. Kirk Harris,
Edith T. Zemanick,
Frank J. Accurso,
Scott D. Sagel,
Robin R. Deterding Tags: Research Article Source Type: research
On ‐Tissue Hydrogel‐Mediated Nondestructive Proteomic Characterization: Application to fr/fr and FFPE Tissues and Insights for Quantitative Proteomics Using a Case of Cardiac Myxoma
ConclusionThe methodology successfully detects numerous protein signals from FFPE and frozen specimens and is able to differentiate between tissue regions. A fast and reliable tissue preparation for quantitative protein analysis by minimum sample manipulation is developed. This offers an option for on ‐tissue proteomics analysis while preserving the inherent spatial information on the tissue. (Source: Proteomics. Clinical Applications)
Source: Proteomics. Clinical Applications - November 12, 2018 Category: Biochemistry Authors: Domenico Taverna,
Chiara Mignogna,
Gianluca Santise,
Marco Gaspari,
Giovanni Cuda Tags: Technical Brief Source Type: research
Quantification of calcyclin and heat shock protein 90 in sera from women with and without preeclampsia by mass spectrometry
Conclusion and clinical relevanceBoth interacting proteins calcyclin and heat shock protein 90 were notably changed in preeclamptic patients compared to controls. Calcyclin was already decreased before the onset of preeclampsia in the second trimester and HSP90 was strongly increased in the third trimester. This suggests that these proteins may play a role in the pathogenesis of preeclampsia and ought to be investigated in large cohort studies as molecular biomarkers.This article is protected by copyright. All rights reserved (Source: Proteomics. Clinical Applications)
Source: Proteomics. Clinical Applications - November 11, 2018 Category: Biochemistry Authors: Co şkun Güzel,
Caroline B. den Berg,
Johannes J. Duvekot,
Christoph Stingl,
Thierry P.P. den Bosch,
Marcel der Weiden,
Eric A.P. Steegers,
Regine P.M. Steegers‐Theunissen,
Theo M. Luider Tags: Research Article Source Type: research
Feasibility study for the MALDI ‐MSI analysis of thyroid fine needle aspiration biopsies: evaluating the morphological and proteomic stability over time
This article is protected by copyright. All rights reserved (Source: Proteomics. Clinical Applications)
Source: Proteomics. Clinical Applications - November 9, 2018 Category: Biochemistry Authors: Isabella Piga,
Giulia Capitoli,
Silvia Tettamanti,
Vanna Denti,
Andrew Smith,
Clizia Chinello,
Martina Stella,
Davide Leni,
Mattia Garancini,
Stefania Galimberti,
Fulvio Magni,
Fabio Pagni Tags: Research Article Source Type: research
Identification of proteomic markers in head and neck cancer using MALDI ‐MS Imaging, LC‐MS/MS and Immunohistochemistry
Conclusions and Clinical RelevanceThe combination of MALDI MSI, LC ‐MS/MS and subsequent IHC furnishes a tool suitable for characterizing the molecular heterogeneity of tissue. It is also suited for use in identifying new representative biomarkers to enable a more individualized therapy.This article is protected by copyright. All rights reserved (Source: Proteomics. Clinical Applications)
Source: Proteomics. Clinical Applications - November 9, 2018 Category: Biochemistry Authors: Franziska Hoffmann,
Claudia Umbreit,
Thomas Kr üger,
Daniela Pelzel,
Günther Ernst,
Olaf Kniemeyer,
Orlando Guntinas‐Lichius,
Alexander Berndt,
Ferdinand Eggeling Tags: Research Article Source Type: research
Screening and Identification of Pregnancy Zone Protein (PZP) and Leucine ‐Rich Alpha‐2‐Glycoprotein (LRG) as Potential Serum Biomarkers for Early‐onset Myocardial Infarction using Protein Profile Analysis
Conclusions and clinical relevance: We identified five differential serum proteins in early ‐onset MI using proteomic analysis. Lipoprotein‐related biomarkers further demonstrate the close relationship between lipid metabolism and the disease. Inflammation‐associated LRG and PZP may be novel biomarkers of the disease. In addition, changes in these proteins may partly reveal the possi ble mechanisms in the pathogenesis and pathophysiology of early‐onset MI.This article is protected by copyright. All rights reserved (Source: Proteomics. Clinical Applications)
Source: Proteomics. Clinical Applications - November 8, 2018 Category: Biochemistry Authors: Chao Xuan,
Hui Li,
Le ‐Le Li,
Qing‐Wu Tian,
Qing Wang,
Bei‐Bei Zhang,
Jun‐Jie Guo,
Guo‐Wei He,
Li‐Min Lun Tags: Research Article Source Type: research
Site ‐to‐Site Reproducibility and Spatial Resolution in MALDI‐MSI of Peptides from Formalin‐Fixed Paraffin‐Embedded Samples
Conclusions and Clinical Relevance: Spatial resolution and site ‐to‐site reproducibility can be maintained by adhering to a standardized MALDI‐MSI workflow.This article is protected by copyright. All rights reserved (Source: Proteomics. Clinical Applications)
Source: Proteomics. Clinical Applications - November 8, 2018 Category: Biochemistry Authors: Alice Ly,
R émi Longuespée,
Rita Casadonte,
Petra Wandernoth,
Kristina Schwamborn,
Christine Bollwein,
Christian Marsching,
Katharina Kriegsmann,
Carsten Hopf,
Wilko Weichert,
Jörg Kriegsmann,
Peter Schirmacher,
Mark Kriegsmann,
Sören‐O Tags: Research Article Source Type: research
On ‐Tissue Hydrogel‐Mediated Non‐Destructive Proteomic Characterization: Application to fr/fr and FFPE Tissues and Insights for Quantitative Proteomics using a case of Cardiac Myxoma
PROTEOMICS – Clinical Applications,Volume 0, Issue ja, -Not available-. (Source: Proteomics. Clinical Applications)
Source: Proteomics. Clinical Applications - November 2, 2018 Category: Biochemistry Authors: Domenico Taverna,
Chiara Mignogna,
Gianluca Santise,
Marco Gaspari,
Giovanni Cuda Source Type: research
Matrix ‐Assisted Laser Desorption Ionization (MALDI) Mass Spectrometry Imaging (MSI) of Key Proteins in Corneal Samples from Lattice Dystrophy Patients with TGFBI‐ H626R and R124C Mutation
PROTEOMICS – Clinical Applications,Volume 0, Issue ja, -Not available-. (Source: Proteomics. Clinical Applications)
Source: Proteomics. Clinical Applications - November 2, 2018 Category: Biochemistry Authors: Venkatraman Anandalakshmi,
Guillaume Hochart,
David Bonnel,
Jonathan Stauber,
Shigeto Shimmura,
Rajamani Lakshminaryanan,
Konstantin Pervushin,
Jodhbir S. Mehta Source Type: research
Translating N ‐Glycan Analytical Applications into Clinical Strategies for Ovarian Cancer
PROTEOMICS – Clinical Applications,Volume 0, Issue ja, -Not available-. (Source: Proteomics. Clinical Applications)
Source: Proteomics. Clinical Applications - October 27, 2018 Category: Biochemistry Authors: Matthew T. Briggs,
Mark R. Condina,
Manuela Klingler ‐Hoffmann,
Georgia Arentz,
Arun V. Everest‐Dass,
Gurjeet Kaur,
Martin K. Oehler,
Nicolle H. Packer,
Peter Hoffmann Source Type: research
Identification of Protein Abundance Changes in Hepatocellular Carcinoma Tissues using PCT ‐SWATH
PROTEOMICS – Clinical Applications,Volume 0, Issue ja, -Not available-. (Source: Proteomics. Clinical Applications)
Source: Proteomics. Clinical Applications - October 26, 2018 Category: Biochemistry Authors: Yi Zhu,
Jiang Zhu,
Cong Lu,
Qiushi Zhang,
Wei Xie,
Ping Sun,
Xiaochuan Dong,
Liang Yue,
Yaoting Sun,
Xiao Yi,
Tiansheng Zhu,
Guan Ruan,
Ruedi Aebersold,
Shi'ang Huang,
Tiannan Guo Source Type: research
MALDI ‐MSI Pilot Study Highlights Glomerular Deposits of Macrophage Migration Inhibitory Factor (MIF) as a Possible Indicator of Response to Therapy in Membranous Nephropathy
PROTEOMICS – Clinical Applications,Volume 0, Issue ja, -Not available-. (Source: Proteomics. Clinical Applications)
Source: Proteomics. Clinical Applications - October 25, 2018 Category: Biochemistry Authors: Vincenzo L'Imperio,
Andrew Smith,
Elena Ajello,
Isabella Piga,
Martina Stella,
Vanna Denti,
Silvia Tettamanti,
Renato Alberto Sinico,
Federico Pieruzzi,
Maurizio Garozzo,
Gisella Vischini,
Manuela Nebuloni,
Fabio Pagni,
Fulvio Magni Source Type: research
Implementation of Proteomics Biomarkers in Nephrology: From Animal Models to Human Application?
PROTEOMICS – Clinical Applications,Volume 0, Issue ja, -Not available-. (Source: Proteomics. Clinical Applications)
Source: Proteomics. Clinical Applications - October 18, 2018 Category: Biochemistry Authors: Julie Klein,
Joost P Schanstra Source Type: research
A Novel Strategy to Investigate Tissue ‐Secreted Tumor Microenvironmental Proteins in Serum toward Development of Breast Cancer Early Diagnosis Biomarker Signature
PROTEOMICS – Clinical Applications, EarlyView. (Source: Proteomics. Clinical Applications)
Source: Proteomics. Clinical Applications - October 18, 2018 Category: Biochemistry Authors: Namita Pendharkar,
Snigdha Dhali,
Subodhini Abhang Source Type: research
Urinary Glycopeptide Analysis for the Investigation of Novel Biomarkers
PROTEOMICS – Clinical Applications, EarlyView. (Source: Proteomics. Clinical Applications)
Source: Proteomics. Clinical Applications - October 18, 2018 Category: Biochemistry Authors: Iwona Belczacka,
Martin Pejchinovski,
Magdalena Krochmal,
Pedro Magalh ães,
Maria Frantzi,
William Mullen,
Antonia Vlahou,
Harald Mischak,
Vera Jankowski Source Type: research
