Quantification of calcyclin and heat shock protein 90 in sera from women with and without preeclampsia by mass spectrometry

Conclusion and clinical relevanceBoth interacting proteins calcyclin and heat shock protein 90 were notably changed in preeclamptic patients compared to controls. Calcyclin was already decreased before the onset of preeclampsia in the second trimester and HSP90 was strongly increased in the third trimester. This suggests that these proteins may play a role in the pathogenesis of preeclampsia and ought to be investigated in large cohort studies as molecular biomarkers.This article is protected by copyright. All rights reserved

Source: Proteomics. Clinical Applications - November 11, 2018 Category: Biochemistry Authors: Co şkun Güzel, Caroline B. den Berg, Johannes J. Duvekot, Christoph Stingl, Thierry P.P. den Bosch, Marcel der Weiden, Eric A.P. Steegers, Regine P.M. Steegers‐Theunissen, Theo M. Luider Tags: Research Article Source Type: research