Continuous donor perfusion for heart preservation
One of the keys to successful cardiac transplantation is preservation of the heart during explantation, transport and implantation. To date the most commonly used method has been cold static storage and this currently remains the only method available for pediatric recipients. However, there has long been interest in continuous perfusion of the donor organ during the ex vivo period to mitigate the effects of ischemia and this is now becoming a clinical reality for adult recipients with good short and early midterm results. (Source: Progress in Pediatric Cardiology)
Source: Progress in Pediatric Cardiology - July 24, 2017 Category: Cardiology Authors: Richard Kirk, Anne I. Dipchand Tags: Review Source Type: research
Induced pluripotent stem cell-derived cardiomyocytes: A platform for testing for drug cardiotoxicity
Off-target cardiotoxicity has been a significant impediment to the development of new drugs. Traditional platforms for screening for cardiotoxicity are both overly sensitive and limited in their ability to predict cardiotoxicity that is often only uncovered after years of clinical use. A major impediment has been the lack of a human cardiomyocyte cell line. The recent discovery that adult somatic human cells (white blood cells or skin fibroblasts) can be reprogrammed into pluripotent stem cells (hiPSCs) and then differentiated into beating cardiomyocytes (hiPSC-CMs) provides an exciting new platform for drug cardiotoxicity...
Source: Progress in Pediatric Cardiology - July 18, 2017 Category: Cardiology Authors: Daniel Bernstein Tags: Review Source Type: research
Non-cardiac targets to treat heart failure in children: Anemia, Exercise, Nutrition, Proceedings from the 4th International Conference on Cardiomyopathy in Children, Bethesda, May 17, 2017
Anemia, exercise, and nutrition are areas which have been studied extensively as targets to modify outcomes in adult heart failure. Non cardiac targets to improve heart failure outcomes in children are not well established and clinical trials related to pediatric heart failure have been limited. The purpose of this article is to highlight potential therapeutic targets and outcome measures, specifically related to iron deficiency, exercise training, and malnutrition, that can be considered for research protocol development with clinical implications. (Source: Progress in Pediatric Cardiology)
Source: Progress in Pediatric Cardiology - July 17, 2017 Category: Cardiology Authors: Beth D. Kaufman, Katelin Dennis, Seda E. Tierney Tags: Review Source Type: research
Analysis of Myocardial Fibrosis in Children with Hypertrophic Cardiomyopathy: A Report from the Pediatric Cardiomyopathy Registry
Myocardial fibrosis in patients with hypertrophic cardiomyopathy has been shown to have prognostic implications for sudden death. Present studies suggest using a threshold of 15% late gadolinium enhancement (LGE) on MRI as an indication for ICD placement for primary prevention in adults. (Source: Progress in Pediatric Cardiology)
Source: Progress in Pediatric Cardiology - July 17, 2017 Category: Cardiology Authors: Sonya Kirmani, Pamela Woodard, Charles E. Canter, Ling Shi, Paul Commean, Melanie Everitt, Elfriede Paul, Wendy K. Chung, Joseph Rossano, Kimberly Molina, Jason Czachor, James D. Wilkinson, Ashley Hill, Janine Wuebbles, Hiedy Razoky, Steven E. Lipshultz Source Type: research
Significant Mortality and Resource Utilization Associated With Advanced Heart Failure Hospitalizations In Congenital Heart Disease
Purpose: Children congenital heart disease (CHD) are at risk for developing advanced heart failure (AHF). However, there are few data on AHF in this population. We sought to define the mortality and resource utilization in this cohort. (Source: Progress in Pediatric Cardiology)
Source: Progress in Pediatric Cardiology - July 17, 2017 Category: Cardiology Authors: Danielle Burstein, Pirouz Shamszad, Christopher Almond, Jack Price, Kimberly Lin, Matthew O'Connor, Robert Shaddy, Christopher Mascio, Joseph Rossano Source Type: research
Phenotypic variability and outcome of arrhythmogenic cardiomyopathy in pediatric and adolescent patients
Arrhythmogenic cardiomyopathy (ACM) is a rare, variably penetrant disease in the young, although as a broader phenotype has been recognized, more cases are identified. (Source: Progress in Pediatric Cardiology)
Source: Progress in Pediatric Cardiology - July 17, 2017 Category: Cardiology Authors: E.S. DeWitt, S.F. Chandler, V. Beausejour-Ladouceur, E. Blume, C. VanderPluym, A.J. Powell, F. Fynn-Thompson, A. Roberts, R. Hylind, S.P. Sanders, N.K. Lakdawala, C.A. MacRae, D.J. Abrams Source Type: research
The echocardiographic risk assessment of donor hearts for consideration of transplantation
Pediatric patients waiting for heart transplantation experience the highest waiting list mortality compared to all other age groups and across all solid organ waiting lists. A significant number of potential donor hearts go unutilized every year due to “marginal” quality. Echocardiography is one of the single most important tools for the examination of donor heart function. Echocardiography can identify donor hearts that can be used successfully in transplantation despite the presence of clinical factors that could lead to exclusion. (Source: Progress in Pediatric Cardiology)
Source: Progress in Pediatric Cardiology - July 12, 2017 Category: Cardiology Authors: Jessica A. Laks, Anne I. Dipchand Tags: Review Source Type: research
Noncompaction cardiomyopathy and heterotaxy syndrome
This study sought to determine whether a non-random association of LVNC and heterotaxy exists by evaluating the prevalence of LVNC in patients with heterotaxy.In a retrospective review of the Indiana Network for Patient Care, we identified 172 patients with heterotaxy (69 male, 103 female). (Source: Progress in Pediatric Cardiology)
Source: Progress in Pediatric Cardiology - July 10, 2017 Category: Cardiology Authors: Hugo R. Martinez, Stephanie M. Ware, Marcus S. Schamberger, John J. Parent Source Type: research
Serum biomarkers for primary graft failure in pediatric heart transplantation
Primary graft failure has been broadly defined as cardiac and circulatory insufficiency in the immediate postoperative period after cardiac transplantation. Risk factors for primary graft failure have been identified in the donor, recipient, and within the perioperative period. Donor serum biomarkers have been identified. The use of donor serum cardiac troponin levels, while most studied, is of questionable value. Basic markers of renal and hepatic function in the recipient are associated with risk of hospital mortality after transplant. (Source: Progress in Pediatric Cardiology)
Source: Progress in Pediatric Cardiology - June 30, 2017 Category: Cardiology Authors: Charles E. Canter Tags: Review Source Type: research
Fulminant viral myocarditis treated by interferon-beta in a child
The fulminant viral myocarditis is associated to a high risk of mortality and heart transplantation in children. Anti-inflammatories and intravenous gamma globulin are used in the majority of studies but the outcome is not always favorable. In this case, we suggest an important role for antiviral therapy in children's fulminant myocarditis. (Source: Progress in Pediatric Cardiology)
Source: Progress in Pediatric Cardiology - June 29, 2017 Category: Cardiology Authors: Nabil Tahhan, Rose Fesseau, Lionel Berthomieu, Khaled Hadeed, Fabio Cuttone, Yves Dulac Source Type: research
Fulminant viral myocarditis treated by interferon-beta in children
The fulminant viral myocarditis is associated to a high risk of mortality and heart transplantation in children. Anti-inflammatories and intravenous gamma globulin are used in the majority of studies but the outcome is not always favorable. In this case, we suggest an important role for antiviral therapy in children's fulminant myocarditis. (Source: Progress in Pediatric Cardiology)
Source: Progress in Pediatric Cardiology - June 29, 2017 Category: Cardiology Authors: Nabil Tahhan, Rose Fesseau, Lionel Berthomieu, Khaled Hadeed, Fabio Cuttone, Yves Dulac Source Type: research
Clinical outcome and inflammatory response after transfusion of washed and unwashed red blood cells in children following cardiovascular surgery
Children frequently require red blood cell transfusion after cardiac surgery, which can generate an inflammatory response that is associated with increased morbidity and mortality. The aim of this study was to evaluate the inflammatory response and clinical effect of RBC transfusion in children.In a pediatric prospective controlled clinical trial 48 children were randomized to an unwashed or washed red blood cell transfusion group after cardiac surgery. Red blood cells were washed using an auto transfusion device with blood gas analyses of the packed red blood cells performed before transfusion. (Source: Progress in Pediatric Cardiology)
Source: Progress in Pediatric Cardiology - June 26, 2017 Category: Cardiology Authors: Christine Busch, Constanze Pfitzer, Sonja Raschzok, Oliver Mieraa, Felix Berger, Katharina Rose Schmitt Source Type: research
Coronary artery dilatation in Systemic Lupus Erythematosus
The echocardiographic finding of dilated coronary arteries has long been associated with Kawasaki disease. When this finding is encountered in clinical practice, Kawasaki disease is almost always the first consideration of Pediatric Cardiologists. In this manuscript we present the case of an 11-year-old girl found to have coronary artery dilatation in the setting of lymphadenopathy and fever initially presumed to be secondary to Kawasaki disease, but was later revealed to be secondary to Systemic Lupus Erythematosus. (Source: Progress in Pediatric Cardiology)
Source: Progress in Pediatric Cardiology - June 22, 2017 Category: Cardiology Authors: Thomas J. Blount, Sunita J. Ferns Source Type: research
Multimodality imaging in prenatal diagnosis and management of aortic arch anomalies
This study aims to present our experience and fetal cardiac output data from a cohort of patients with discrete aortic coarctation and aortic arch hypoplasia. (Source: Progress in Pediatric Cardiology)
Source: Progress in Pediatric Cardiology - June 21, 2017 Category: Cardiology Authors: Bryan Jepson, Shanthi Sivanandam Source Type: research
Markers as predictors of clinical worsening in pulmonary arterial hypertension
Various biomarkers have been demonstrated to represent prognostic markers in adult patients with pulmonary arterial hypertension (PAH), however few data are available on their value in pediatric population. We aimed to assess the role of serum and imaging markers, such as B-type natriuretic peptide (BNP) and echocardiography-derived parameters characterizing right ventricular function and hemodynamics, in predicting clinical worsening in pediatric PAH. In 28 pediatric patients with PAH (group 1 - patients clinically stable at 12months “no clinical worsening”, n=14, 50%; group 2 - patients with clinical worsening at 12m...
Source: Progress in Pediatric Cardiology - June 21, 2017 Category: Cardiology Authors: Suteu Carmen Corina, Blesneac Cristina, Muntean Iolanda, Benedek Imre, Benedek Theodora, Iarca Ionut, Melinte Mihaela, Tog ănel Rodica Source Type: research
