Transvenous arterial duct stenting in cyanotic patients with pulmonary atresia and ventricular septal defect
We aimed to study the feasibility and outcomes of transvenous approach for arterial duct stenting in patients with pulmonary atresia-ventricular septal defect. Duct-dependent hypoxic patients with pulmonary atresia-ventricular septal defect and the confluent pulmonary artery branches were enrolled for ductal stenting and followed-up regularly. Twenty-three patients, with median age of 25days (1 to 545days) and weight of 2.8kg (2.1 to 7.2kg) were enrolled. Mean baseline arterial oxygen saturation was 69.38 ±8.04%. (Source: Progress in Pediatric Cardiology)
Source: Progress in Pediatric Cardiology - August 9, 2016 Category: Cardiology Authors: Bhavesh Thakkar, Abhishek Raval, Tarun Madan, Nilesh Oswal, Rhshikesh Umalkar, Komal Shah, Bhumika Maheriya Source Type: research
Mechanical Circulatory Support in Children: Challenges and Opportunities
Adoption and utilization of mechanical circulatory support has evolved into a standard of care practice for advanced heart failure and cardiorespiratory failure. The cumulative experience worldwide has generally led to improvement in technology as well as patient outcomes. Data from the international Extracorporeal Life Support Organization (ELSO) registry shows that extracorporeal life support has been utilized to support>52,000 patients just within the participating centers [1]. Similarly, the INTERMACS registry report documents>15,000 patients supported with ventricular assist devices (VAD) from 158 participating hospit...
Source: Progress in Pediatric Cardiology - August 6, 2016 Category: Cardiology Authors: Deshpande, K.O. Maher, D.L. Morales Tags: Review Source Type: research
Cardiac resynchronization therapy in children with heart failure
Cardiac resynchronization therapy (CRT) is a widely utilized and effective therapy for adults with ventricular dysfunction and some degree of ventricular conduction delay. By pacing late-contracting regions of ventricle earlier than intrinsic conduction would allow, ventricular dyssynchrony is reduced, the ventricular contraction is more efficient [1,2], and thus cardiac output improves. [3] As cardiac output improves, the clinical symptoms of heart failure also improve, and if the patient responds to the therapy, long-term survival benefit has also been observed [4]. (Source: Progress in Pediatric Cardiology)
Source: Progress in Pediatric Cardiology - July 28, 2016 Category: Cardiology Authors: Anthony C. McCanta, James C. Perry Tags: Review Source Type: research
Recent advances in heart transplant immunology: The role of antibodies
Heart transplantation (HT) has been an accepted therapy for end-stage heart failure in children since the 1980s. Despite improvements in early survival, long-term outcomes remain relatively unchanged [1], partly due to chronic, immune-mediated damage to the graft, which is distinct from the histologic changes observed in acute cellular rejection (ACR). Antibody-mediated rejection (AMR) is defined by the International Society for Heart and Lung Transplantation as the presence of endothelial injury on biopsy specimens along with immunohistochemical evidence of complement deposition in the graft [2]. (Source: Progress in Pediatric Cardiology)
Source: Progress in Pediatric Cardiology - July 28, 2016 Category: Cardiology Authors: Matthew J. O'Connor, Elfriede Pahl, Steven A. Webber, Joseph W. Rossano Tags: Review Source Type: research
Advantages, disadvantages and alternatives to using adult heart failure clinical trials to guide pediatric heart failure therapy
Heart failure in the adult population is a major public health issue with an estimated prevalence of 5.8 million affected adults in the USA and over 23 million worldwide [1]. The majority of adult heart failure in Western High Income locations is related to ischemia, hypertension and valvular heart disease [2]. Other comorbidities are common, including diabetes, renal insufficiency, arrhythmias and hypercholesterolemia. The diagnosis of heart failure in adult patients carries a significant risk of death. (Source: Progress in Pediatric Cardiology)
Source: Progress in Pediatric Cardiology - July 28, 2016 Category: Cardiology Authors: Daphne T. Hsu, Robert E. Shaddy Tags: Review Source Type: research
Regenerative medicine - From stem cell biology to clinical trials for pediatric heart failure
Progressive heart failure in children and young adults is a serious problem, with an overall mortality of 7% in the United States [1]. In the past, the vast majority of children with heart failure had either cardiomyopathy or myocarditis, however, with improved surgical survival of high risk neonates with congenital heart disease, the incidence of heart failure due to structural heart disease has increased dramatically. There are critical differences in the response to injury between the young and the mature heart, where in the former the potential for regeneration is greater, in comparison to the more limited response in ...
Source: Progress in Pediatric Cardiology - July 28, 2016 Category: Cardiology Authors: Susana Cantero Peral, Daniel Bernstein, Timothy J. Nelson Tags: Review Source Type: research
Anatomically corrected malposition of the great arteries: Review of the literature
Anatomically corrected malposition of the great arteries (ACMGA) is a rare form of congenital heart disease in which the great arteries arise above the anatomically correct ventricles but are abnormally related to the ventricles and one to the other with aorta in an anterior position. The diagnosis is specially challenging in adult patients with poor acoustic window. A review of published cases on PubMed, was performed in order to provide insights and potential pitfalls in diagnosing this clinical condition mainly in biventricular ACMGA. (Source: Progress in Pediatric Cardiology)
Source: Progress in Pediatric Cardiology - July 28, 2016 Category: Cardiology Authors: Lamia Ait-Ali, Rosa Sicari, Pierluigi Festa Source Type: research
The Benefits and Hazards of Publicly Reporting Quality Outcomes
Public reporting of outcomes data is increasingly accepted as a reality, but it is not without controversy and challenges. Research from various non-healthcare industries indicates that the decision to change systems or processes (i.e., performance improvement) often depends on the perceptions of the individuals who must implement these changes [1]. Public reporting of outcome data represents a more substantial environmental change worldwide as the healthcare industry moves toward greater transparency and accountability. (Source: Progress in Pediatric Cardiology)
Source: Progress in Pediatric Cardiology - June 6, 2016 Category: Cardiology Authors: Paul R. Barach, Steven E. Lipshultz Tags: Editorial Source Type: research
Editorial Board
(Source: Progress in Pediatric Cardiology)
Source: Progress in Pediatric Cardiology - May 31, 2016 Category: Cardiology Source Type: research
Progress in Pediatric Cardiology
Cardiorenal syndrome (CRS) includes the disorders of the heart and kidneys where “acute or chronic dysfunction in one organ may induce acute or chronic dysfunction of the other” (Ronco, C.; McCullough, S.D. (2010). "Cardio-renal syndromes: Reports from the consensus conference of the acute dialysis quality initiative". European Heart Journal 31 (6): 703–711.). There are 5 types of CRS, with type 1 and type 3 being acute, and type 2 and 4 being chronic. Type 2 involves progressive chronic kidney disease (CKD) in patients with chronic abnormalities in heart function. (Source: Progress in Pediatric Cardiology)
Source: Progress in Pediatric Cardiology - May 31, 2016 Category: Cardiology Tags: Preface Source Type: research
Future Topics and Guest Editors
(Source: Progress in Pediatric Cardiology)
Source: Progress in Pediatric Cardiology - May 31, 2016 Category: Cardiology Source Type: research
Future Meetings
(Source: Progress in Pediatric Cardiology)
Source: Progress in Pediatric Cardiology - May 31, 2016 Category: Cardiology Source Type: research
Editorial Board
(Source: Progress in Pediatric Cardiology)
Source: Progress in Pediatric Cardiology - May 31, 2016 Category: Cardiology Source Type: research
Progress in Pediatric Cardiology
Cardiorenal syndrome (CRS) includes the disorders of the heart and kidneys where “acute or chronic dysfunction in one organ may induce acute or chronic dysfunction of the other” (Ronco, C.; McCullough, S.D. (2010). "Cardio-renal syndromes: Reports from the consensus conference of the acute dialysis quality initiative". European Heart Journal 31 (6): 703–711.). There are 5 types of CRS, with type 1 and type 3 being acute, and type 2 and 4 being chronic. Type 2 involves progressive chronic kidney disease (CKD) in patients with chronic abnormalities in heart function. (Source: Progress in Pediatric Cardiology)
Source: Progress in Pediatric Cardiology - May 31, 2016 Category: Cardiology Tags: Preface Source Type: research
